ID A0A0K1S1B0_9CHRO Unreviewed; 601 AA.
AC A0A0K1S1B0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=aspartate kinase {ECO:0000256|ARBA:ARBA00013059};
DE EC=2.7.2.4 {ECO:0000256|ARBA:ARBA00013059};
GN ORFNames=VL20_2793 {ECO:0000313|EMBL:AKV67845.1};
OS Microcystis panniformis FACHB-1757.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=1638788 {ECO:0000313|EMBL:AKV67845.1};
RN [1] {ECO:0000313|EMBL:AKV67845.1, ECO:0000313|Proteomes:UP000068167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FACHB-1757 {ECO:0000313|EMBL:AKV67845.1,
RC ECO:0000313|Proteomes:UP000068167};
RX PubMed=26823957; DOI=10.1186/s40793-016-0130-5;
RA Zhang J.Y., Guan R., Zhang H.J., Li H., Xiao P., Yu G.L., Du L., Cao D.M.,
RA Zhu B.C., Li R.H., Lu Z.H.;
RT "Complete genome sequence and genomic characterization of Microcystis
RT panniformis FACHB 1757 by third-generation sequencing.";
RL Stand. Genomic Sci. 11:11-11(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000709};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004766, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-homoserine from L-aspartate: step 1/3.
CC {ECO:0000256|ARBA:ARBA00004986, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 1/5. {ECO:0000256|ARBA:ARBA00005139,
CC ECO:0000256|RuleBase:RU004249}.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
CC {ECO:0000256|ARBA:ARBA00010122}.
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DR EMBL; CP011339; AKV67845.1; -; Genomic_DNA.
DR RefSeq; WP_052276579.1; NZ_CP011339.1.
DR AlphaFoldDB; A0A0K1S1B0; -.
DR KEGG; mpk:VL20_2793; -.
DR PATRIC; fig|1638788.3.peg.2804; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR Proteomes; UP000068167; Chromosome.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04261; AAK_AKii-LysC-BS; 1.
DR CDD; cd04923; ACT_AK-LysC-DapG-like_2; 2.
DR CDD; cd04913; ACT_AKii-LysC-BS-like_1; 2.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR Gene3D; 3.30.2130.10; VC0802-like; 2.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR041740; AKii-LysC-BS.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR005260; Asp_kin_monofn.
DR InterPro; IPR001341; Asp_kinase.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR InterPro; IPR027795; CASTOR_ACT_dom.
DR NCBIfam; TIGR00656; asp_kin_monofn; 1.
DR NCBIfam; TIGR00657; asp_kinases; 1.
DR PANTHER; PTHR21499; ASPARTATE KINASE; 1.
DR PANTHER; PTHR21499:SF3; ASPARTOKINASE; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF01842; ACT; 2.
DR Pfam; PF13840; ACT_7; 2.
DR SUPFAM; SSF55021; ACT-like; 4.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
DR PROSITE; PS51671; ACT; 3.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW ECO:0000256|RuleBase:RU004249};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AKV67845.1};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 273..352
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT DOMAIN 360..427
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT DOMAIN 448..536
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 601 AA; 63653 MW; 1103B9FFF4736CEF CRC64;
MAVIVQKYGG TSVGSVERIQ SVAQRVKNTV IAGNTVVVVV SAMGKTTDGL VNLAKQIAAE
PSRREMDMLL STGEQVTIAL MSMALEEIGQ PAISLTGAQV GIVTESEHSR ARILEIKTDR
LSRHLSEGKV VVVAGFQGVS DSDQLEITTL GRGGSDTSAV ALAAALKADF CEIYTDVPGI
LTTDPRLVPE ARLLDEITCD EMLELASLGA KVLHPRAVEI AKNFGVPLVV RSSWTEEPGT
WVTSPAPKPR TLQGLELTKA VDAVEFEGNQ AKIALLRVPD RPGIAARLFG EIAHQQVDVD
LIIQSIHEGD SNDIAFTVMG NALKKAQSVA EAIAPVLRSH PTNTEEAEVI IESGAAKIAI
TGAGMIGRPG IAAQIFSTLA AAAINIEMIS TSEVKVSCVI DEADGEKAIK VLCDAFQVEY
SAKVANREIP KNLVPVRGVA LDNNQAQMAI RNVPDRPGMA ARIFSVLAAK NVSVDMIIQS
QRCRIVDGIP RRDIAFTLPQ ADANSAQKIL LELSESLGLQ EVVVNNDVAK VSIVGSGMEG
QPGVAARFFE ALAKEKINIL MIATSDIKIS CVVNQEDGVR SLQVVHAAFG LAGQGKIEVP
A
//
