ID A0A0U1RK18_NEIMA Unreviewed; 378 AA.
AC A0A0U1RK18;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3-oxoacyl-(Acyl-carrier-protein) synthase II {ECO:0000313|EMBL:CAM09069.1};
DE EC=2.3.1.41 {ECO:0000313|EMBL:CAM09069.1};
GN OrderedLocusNames=NMA1957 {ECO:0000313|EMBL:CAM09069.1};
OS Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS Z2491).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122587 {ECO:0000313|EMBL:CAM09069.1, ECO:0000313|Proteomes:UP000000626};
RN [1] {ECO:0000313|EMBL:CAM09069.1, ECO:0000313|Proteomes:UP000000626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15465 / Z2491 {ECO:0000313|Proteomes:UP000000626};
RX PubMed=10761919; DOI=10.1038/35006655;
RA Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C., Klee S.R.,
RA Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P.,
RA Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S.,
RA Moule S., Mungall K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G.;
RT "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT Z2491.";
RL Nature 404:502-506(2000).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; AL157959; CAM09069.1; -; Genomic_DNA.
DR RefSeq; WP_002246375.1; NC_003116.1.
DR AlphaFoldDB; A0A0U1RK18; -.
DR EnsemblBacteria; CAM09069; CAM09069; NMA1957.
DR KEGG; nma:NMA1957; -.
DR HOGENOM; CLU_000022_69_2_4; -.
DR Proteomes; UP000000626; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF325; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE II FABF; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:CAM09069.1};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:CAM09069.1}.
FT DOMAIN 1..378
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 378 AA; 40262 MW; 52F2DF23ED1015A9 CRC64;
MDWHERFPEL EAQLGAPIEN YAPPKHWTRK QLRSMGRVSY LCVDAAEQAL TDAGLLGDES
ITDGRMGVAC GSSSGSTKDI GDVGELLLTG MSRNFSANTY VRMMPHTAAA NIGIFFGLKG
RIIPTSSACS SGSQGIGYAY EAIKYGLTDM MLAGGGEEFF PSEVYVFDSL YAASRRNGEP
EKTPRPYDAN RDGLVIGEGA GIFVLEELEH AKRRGAIIYA ELVGYGANSD AYHISTPRPD
AQGAILAFQT ALQHADLAPE DIGWINLHGT GTHHNDSMES RAVAAVFGNN TPCTSTKPQT
GHTLGAAGAI EAAFAWGIAD RKSNPEGKLP PQLWDGQNDP DLPAINLTGS GSRWETEKRI
AASSSFAFGG SNCVLLIG
//
