ID A0A142D0X3_9BACI Unreviewed; 348 AA.
AC A0A142D0X3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00014165, ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|ARBA:ARBA00013185, ECO:0000256|PIRNR:PIRNR005096};
GN ORFNames=A0V43_06815 {ECO:0000313|EMBL:AMQ20675.1};
OS Geobacillus sp. JS12.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=1813182 {ECO:0000313|EMBL:AMQ20675.1};
RN [1] {ECO:0000313|EMBL:AMQ20675.1, ECO:0000313|Proteomes:UP000071670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS12 {ECO:0000313|EMBL:AMQ20675.1,
RC ECO:0000313|Proteomes:UP000071670};
RA Kim H.-W.;
RT "Complete genome sequence of the crude oil-degrading thermophilic bacterium
RT Geobacillus sp. JS12.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001614,
CC ECO:0000256|PIRNR:PIRNR005096};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; CP014749; AMQ20675.1; -; Genomic_DNA.
DR RefSeq; WP_063192705.1; NZ_CP014749.1.
DR AlphaFoldDB; A0A142D0X3; -.
DR KEGG; gej:A0V43_06815; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000071670; Chromosome.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR018052; Ald1_epimerase_CS.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF50; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096}.
FT ACT_SITE 179
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 313
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 179..181
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 252
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 348 AA; 38816 MW; F62F8F0EA85CA176 CRC64;
MRIRKETWSC FNEKDVLLFT LTNEHGMELS TTNYGCIVTD LRVPDRNGNI ENVVLGFGRF
EPYVENAPYF GAVIGRVAGR IRGASFELDG ITYQLAKNEH NNHLHGGPSG FHRVLWQAEP
VQRDGAVGVV FSYTSPDGEE GYPGTVHVQV EYWLNNDNEW TVTHRARSDK TTLLNLTNHT
YFNLSGNGKR DILDHTLTIQ SSRVLELNEE MIPTGRVLDV AGTPFDLRQG KAIWEAVESG
HPQIELVGGG YDHPFWLDRH HDKEIVLSDP ESGRVLTVET DEVGVVVYTS NQLPEGLDLG
GVPSRKYLGV CLETQGLPDA VHHPQFPSIV LPAGQERAST TVYRFGII
//
