ID A0A1A9I220_9BACT Unreviewed; 396 AA.
AC A0A1A9I220;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00014165, ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|ARBA:ARBA00013185, ECO:0000256|PIRNR:PIRNR005096};
GN ORFNames=A8C56_06905 {ECO:0000313|EMBL:ANH80742.1};
OS Niabella ginsenosidivorans.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Niabella.
OX NCBI_TaxID=1176587 {ECO:0000313|EMBL:ANH80742.1, ECO:0000313|Proteomes:UP000077667};
RN [1] {ECO:0000313|EMBL:ANH80742.1, ECO:0000313|Proteomes:UP000077667}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BS26 {ECO:0000313|EMBL:ANH80742.1,
RC ECO:0000313|Proteomes:UP000077667};
RA Im W.T., Siddiqi M.Z.;
RT "Niabella ginsenosidivorans BS26 whole genome sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001614,
CC ECO:0000256|PIRNR:PIRNR005096};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; CP015772; ANH80742.1; -; Genomic_DNA.
DR RefSeq; WP_067753751.1; NZ_CP015772.1.
DR AlphaFoldDB; A0A1A9I220; -.
DR STRING; 1176587.A8C56_06905; -.
DR KEGG; nia:A8C56_06905; -.
DR OrthoDB; 9779408at2; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000077667; Chromosome.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR018052; Ald1_epimerase_CS.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF50; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096};
KW Reference proteome {ECO:0000313|Proteomes:UP000077667}.
FT ACT_SITE 222
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 361
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 125..126
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 222..224
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 294
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 396 AA; 42641 MW; A3DE3309689D7E04 CRC64;
MSHSLKFFAV AALALGIAAC NDNSAEKKES AATDSTAVKT DDTPESLDSA KFVAMIDGKK
TALYQLTNHK GMTVAITNYG GRIAGIWVPD KEGKQTDVAW GMSSVDAFEK SDMAYLGALI
GRYGNRIGHA QFQLDGKTYP LAANDGPNTL HGGKKGFQAV VWDAAQPNDS TLELMYTSPD
MEEGFPGTLN VKVVYSVTAD NALKIDYSAT TDKNTIVNLT NHAYFNLNGE GSGEILGHTV
QIYADKYTPV DSTLIPTGKL EPVAGTPLDF TKPAAIGARI NDDNEQLKFG KGYDHNYVLN
GTKGLYGLTH AATFTGDKSG ISMDIYTQEP GLQFYSGNFN KSTNTLKSGA KDIHRGAFAA
ETQHFPDSPN KPAFPSTELK AGQQYHTVTY YKFSSK
//
