ID A0A1L6R7R8_9FLAO Unreviewed; 396 AA.
AC A0A1L6R7R8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|PIRNR:PIRNR005096};
GN ORFNames=AO058_17530 {ECO:0000313|EMBL:APS40565.1};
OS Salegentibacter sp. T436.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Salegentibacter.
OX NCBI_TaxID=1729720 {ECO:0000313|EMBL:APS40565.1, ECO:0000313|Proteomes:UP000185442};
RN [1] {ECO:0000313|EMBL:APS40565.1, ECO:0000313|Proteomes:UP000185442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T436 {ECO:0000313|EMBL:APS40565.1,
RC ECO:0000313|Proteomes:UP000185442};
RA Spain J.C., Graham D.E., Mahan K.M., Klingeman D.M., Giannone R.J.,
RA Hettich R.L., Parry R.J.;
RT "Complete genome sequence of Salegentibacter sp. T436.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|PIRNR:PIRNR005096};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; CP012872; APS40565.1; -; Genomic_DNA.
DR RefSeq; WP_075327734.1; NZ_CP012872.1.
DR AlphaFoldDB; A0A1L6R7R8; -.
DR STRING; 1729720.AO058_17530; -.
DR KEGG; salt:AO058_17530; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000185442; Chromosome.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF50; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096}.
FT ACT_SITE 220
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 360
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 123..124
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 292
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 396 AA; 44780 MW; 41378BB35479644F CRC64;
MKQIYFLMII SCLSTVFYSC KEETKSTKGL ASKESQAVKN NPEKFLKAEN FDTIIDNKKV
RLYWLENDRI KAAFTNYGGR LIGLWVPNRK GEMTDVVVGM NSVKGFVDST EPYFGATIGR
VGNRIADGKF QLEDKEYNIP KNNGENSLHG GNKGFQYVVW DATQPEKNKL VLEYQSPDME
EGFPGNLDVK VTYSLTDDQE IVMEYEATTD KATPVNLTNH AFFNLNGEGS GEILDHQLQL
HAHKFTPVDS GLIPTGELRE VQGTPFDFRE FHRIGERIEE NNKQLTYGKG YDHNFVLHQG
ESKFQDLNHA ASVIGDQSGI KMDVFTEEPG IQFYSGNFMA GKNKFKSGAA DEFRTAFALE
TQHFPDAPNQ DDFPSIILEP GEKYQTLSKY KFSVKE
//
