ID   A0A1L8EL46_XENLA        Unreviewed;       892 AA.
AC   A0A1L8EL46;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Mitogen-activated protein kinase kinase kinase 14 {ECO:0000313|RefSeq:XP_018093574.1};
GN   Name=map3k14.S {ECO:0000313|RefSeq:XP_018093574.1,
GN   ECO:0000313|Xenbase:XB-GENE-17338713};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018093574.1};
RN   [1] {ECO:0000313|RefSeq:XP_018093574.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018093574.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018093574.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_018093574.1; XM_018238085.2.
DR   AlphaFoldDB; A0A1L8EL46; -.
DR   STRING; 8355.A0A1L8EL46; -.
DR   PaxDb; 8355-A0A1L8EL46; -.
DR   GeneID; 108702551; -.
DR   KEGG; xla:108702551; -.
DR   AGR; Xenbase:XB-GENE-17338713; -.
DR   CTD; 108702551; -.
DR   Xenbase; XB-GENE-17338713; map3k14.S.
DR   OMA; NFTKCIN; -.
DR   OrthoDB; 2970139at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 108702551; Expressed in muscle tissue and 14 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR   PANTHER; PTHR48016:SF9; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_018093574.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transferase {ECO:0000256|ARBA:ARBA00022777,
KW   ECO:0000313|RefSeq:XP_018093574.1}.
FT   DOMAIN          353..608
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         383
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   892 AA;  99314 MW;  539B408457F34D33 CRC64;
     MAVGRQQSSH LDPEIPQKYC KCEGTVAKES AELGMAKNLK NLLPWSDVIE KGTAKEEKQS
     PSLYISIIAQ PECENNHEIC PSFQQHQIYN TDSKQYSHLN IEHTANNVVN STEGKPSHQS
     KPPRIKGKKA KRKRKQKNGS QNPEQRGQRI PEQECRAPIP VQDEESQQSL ESLNVWWTDA
     KQKTSGLKEK HPTISNEHPL QDLCLLKDDR LKEHHKLINL KQCIYHIGGG KLPPSAALHV
     PPLDSLSISE FLKTLGTKSS CDLDYGETTS PEYGSPKLIR PYEDPKTDSV EECMFEALRG
     SVSMGEPKSL STFAKAWNQE ADDENREMDT EGVILTEKLK TEDYEYKEGI HWTKDGEALG
     SGSFGDVLPA KDEQTGVRFA VKKIHQSRFR SQELTSCLWV SSPKLVPVYG AVREGPCINV
     FLKLMTGGSL GQLIKLNGFL PEDRALYYLG QVLEGLTHLH AKSIVHGDIK ADNILLSEDG
     NEAYLSDLGH SAYLPMDGSK KQLLTADYVP GTETHMAPEI VRGDDCDTKL DVWSSCCMML
     HMLNGWHPWS RTHAPPLCLK IATEPPPVQE IPPTCDPQTC EVIVEGLEKD PVRRVTAARL
     QEKVHLALHK IGGLKSPCKS EYKTPRSFPD TTLPPSPVRA TESPISKHEP ALIDTRPSPS
     PNKSKPEFIK EKTISSLTDS SAVRPNILPR KEIQQMEREY LLTNLFLASS LEEQEQMLSC
     LSEDNLDLHR SHKDSLHTFD TASSGIYSWD SEMDPLSLKS DSLNHEGVTT TPSWFNGYKV
     QLQTLSGEKL HIWESGRTKL GDLALGISSQ IPLQSFTILT PEGKPVPWST DIADCGIYLQ
     CALAPDRGGD WIWRVMRGRL EQGPTGEVYT GGGSGGSPCK KEEVFPNTEH PV
//