ID A0A1R3XWD8_MYCBO Unreviewed; 489 AA.
AC A0A1R3XWD8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Probable aldehyde dehydrogenase nad dependent alda (Aldehyde dehydrogenase [nad+]) {ECO:0000313|EMBL:SIT99390.1};
GN Name=aldA {ECO:0000313|EMBL:SIT99390.1};
GN OrderedLocusNames=BQ2027_MB0791 {ECO:0000313|EMBL:SIT99390.1};
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413 {ECO:0000313|EMBL:SIT99390.1, ECO:0000313|Proteomes:UP000001419};
RN [1] {ECO:0000313|Proteomes:UP000001419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97 {ECO:0000313|Proteomes:UP000001419};
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2] {ECO:0000313|EMBL:SIT99390.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AF2122/97 {ECO:0000313|EMBL:SIT99390.1};
RA Malone K.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000001419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97 {ECO:0000313|Proteomes:UP000001419};
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
RN [4] {ECO:0000313|EMBL:CAB0185020.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AF2122/97 {ECO:0000313|EMBL:CAB0185020.1};
RA Farrell D., Gordon V S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:SIT99390.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AF2122/97 {ECO:0000313|EMBL:SIT99390.1};
RA Malone M K., Farrell D., Malone K.;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; LR777660; CAB0185020.1; -; Genomic_DNA.
DR EMBL; LT708304; SIT99390.1; -; Genomic_DNA.
DR RefSeq; NP_854449.1; NC_002945.3.
DR RefSeq; WP_003403919.1; NC_002945.4.
DR AlphaFoldDB; A0A1R3XWD8; -.
DR SMR; A0A1R3XWD8; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07089; ALDH_CddD-AldA-like; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR026460; Aldehyde_dehydrogenase_Rv0768.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR NCBIfam; TIGR04284; aldehy_Rv0768; 1.
DR PANTHER; PTHR42804; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42804:SF1; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000001419}.
FT DOMAIN 21..483
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 489 AA; 51184 MW; 2E2E797008030738 CRC64;
MALWGDGISA LLIDGKLSDG RAGTFPTVNP ATEEVLGVAA DADAEDMGRA IEAARRAFDS
TDWSRNTELR VRCVRQLRDA MQQHVEELRE LTISEVGAPR MLTASAQLEG PVGDLSFAAD
TAESYPWKQD LGEASPLGIA TRRTLAREAV GVVGAITPWN FPHQINLAKL GPALAAGNTV
VLKPAPDTPW CAAALGEIIV EHTDFPPGVV NIVTSSSHAL GALLAKDPRV DMISFTGSTA
TGRAVMADAA ATIKKVFLEL GGKSAFVVLD DADLAAASAV SAFSACMHAG QGCAITTRLV
VPRARYEEAV AIAAATMSSI RPGDPNDPGT VCGPLISARQ RDRVQGYLDL AVAEGGRFAC
GGARPADREV GFYIEPTVIA GLTNDARVAR EEIFGPVLTV IAHDGDDDAV RIANDSPYGL
SGTVYGADPQ RAARIASRLR VGTVNVNGGV WYCADAPFGG YKQSGIGREM GLLGFEEYLE
AKLIATAAN
//
