ID A0A1S2Z4R7_CICAR Unreviewed; 776 AA.
AC A0A1S2Z4R7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Histone-lysine N-methyltransferase EZA1-like {ECO:0000313|RefSeq:XP_004515047.1};
GN Name=LOC101511861 {ECO:0000313|RefSeq:XP_004515047.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004515047.1};
RN [1] {ECO:0000313|RefSeq:XP_004515047.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004515047.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR RefSeq; XP_004515047.1; XM_004514990.3.
DR AlphaFoldDB; A0A1S2Z4R7; -.
DR STRING; 3827.A0A1S2Z4R7; -.
DR PaxDb; 3827-XP_004515047-1; -.
DR GeneID; 101511861; -.
DR KEGG; cam:101511861; -.
DR eggNOG; KOG1079; Eukaryota.
DR OrthoDB; 953423at2759; -.
DR Proteomes; UP000087171; Unplaced.
DR GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10519; SET_EZH; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF14; HISTONE-LYSINE N-METHYLTRANSFERASE EZA1; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS51576; SAM_MT43_EZ; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 503..602
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 616..731
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 743..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 17..44
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 743..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 89246 MW; 9A3225273281F7CC CRC64;
MVPRCAKPNQ SMQEQHVEAA TNDRQTLVNK INLLKEKIQE ERIRSIKDKL KRNGKNLKCA
LSSIMTIVLR NDSFQIEETT FQMLSSRVDH PLYKLSGFPK GLRKNDHINN EDLSFEKSIK
LPYIERVPPY TFWLHLVRNE RMTKDQSFAA RRNIYYEQRG GEALVCSDTD EELKENREVK
HDFSHGEDQI IWMAFEEHNL TKEVLSIVQS YIGGTNSEIE ERYKYLKEKD QHSKESIEDG
YINIDICLEK SLSAALNTFD HLLCRRCLIF DCPLHGCSQP LVYPSEKQQI WNEPEGDRKP
CSDHCYLQLM DANLCSKNST QENIDEILTL SNTEECGNQS KAILEKETCN YGTKPSTAEV
NCLLDLNLDV DVSESEGKEK EVPYEIETKQ LSNSMEKLFN DMHSNSNWKP LEKDLYLKGI
EMFGRNSCLI FRNLLSGFKT CMEIASYMYA EGSMPYGSMD ENGKFDTKGT DHEMPSNSRS
FRRKGKSKKL KYCTKSPGLP SMWRRISEGK DEPYKHYTPC GCEGMCGKQC PCLLKGSCCE
KYCGCGKQCR NRFRGCHCVK SQCRSRQCPC FAAARECDPD VCRSCWISCG DGSLGEPPHR
GDGLCENMKL LLRKKQRILL AKSNVAGWGA FLKNPANKND FLGEYTGEVI SYTEAEKRSK
LYERADFSFL FDLDDQCVLD AYRKGDKLKF ANHSSKPNCY ARIMHVGGDY RVGIFAKERI
EAGEELFYDY HFKDNHRPPA WFLKLSSNNN NNNNNNTSKR KESTDSLGKP KKRDSR
//
