ID A0A1S3Y462_TOBAC Unreviewed; 1020 AA.
AC A0A1S3Y462;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN Name=LOC107772051 {ECO:0000313|RefSeq:XP_016447022.1,
GN ECO:0000313|RefSeq:XP_016447023.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016447023.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016447022.1, ECO:0000313|RefSeq:XP_016447023.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
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DR RefSeq; XP_016447022.1; XM_016591536.1.
DR RefSeq; XP_016447023.1; XM_016591537.1.
DR STRING; 4097.A0A1S3Y462; -.
DR PaxDb; 4097-A0A1S3Y462; -.
DR GeneID; 107772051; -.
DR KEGG; nta:107772051; -.
DR OMA; RDSYCRT; -.
DR OrthoDB; 3597773at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0045252; C:oxoglutarate dehydrogenase complex; IBA:GO_Central.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IBA:GO_Central.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR032106; 2-oxogl_dehyd_N.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23152:SF37; OXOGLUTARATE DEHYDROGENASE (SUCCINYL-TRANSFERRING); 1.
DR Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 635..848
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 1020 AA; 115638 MW; 45DB21ED518346EE CRC64;
MAWFRAGSSV ARLAIRRALS QGGSYVPRTR VLPSQGRCFH TTVARPKAQA APVPRPVPLS
KLTDSFLDGT SSVYLEELQR AWEQDPNSVD ESWDNFFRNF VGQAATSPGI SGQTIQESMR
LLLLVRAYQV NGHMKAKLDP LGLEEREIPD DLDPALYGFT EADLDREFFL GVWRMSGFLS
ENRPVQTLRA ILTRLEQAYC GSIGYEYMHI SDRDKCNWLR ERIETPTSME YNRERREVIL
DRLMWSTQFE NFLATKWMAA KRFGLEGCET LIPGMKEMFD RAADLGVESI VIGMPHRGRL
NVLGNVVRKP LKQIFSEFSG GTKPGDEAGY VGTGDVKYHL GTSYDRPTRG GKRIHLSLVA
NPSHLEAVDP VVIGKTRAKQ YYSNDVDRTK NMGILLHGDG SFAGQGVVYE TLHLSALPNY
STGGTIHIVV NNQVAFTTDP RAGRSSQYCT DVAKALNAPI FHVNGDDVEA VAHVCELAAE
WRQKFHSDVV VDIVCYRRFG HNEIDEPSFT QPKMYKIIRN HPSSLEIYQN KLLKSGQVTK
DDVEKIHNKI NRILNEEFVA SKDYVPQKRD WLSAFWAGFK SPSQLSRVRN TGVKPEILKN
VGKAITTLPD DFKPHRAVKR IFDDRRKMIE TGEGVDWAVG EALAFATLLV EGNHVRLSGQ
DVERGTFSHR HSVLHDQETG AQYCPLDHVM MNQNEEMFTV SNSSLSEFGV LGFELGYSME
NPNSLVLWEA QFGDFANGAQ VIFDQFVSSG EAKWLRQSGL VVLLPHGYDG QGPEHSSGRL
ERFLQMSDDN PFVIPEMEPT LRKQIQECNW QVVNVTTPAN YFHVLRRQIH RDFRKPLIVM
APKNLLRHKD CKSNLSEFDD VQGHPGFDKQ GTRFKRLIKD QNDHSDLEEG IRRLVLCSGK
IYYELDEERK KANGKDVAIC RVEQLCPFPY DLIQRELKRY PNAEIVWCQE EPMNMGAFHY
IAPRLCTAMK SLGRGNMDDI KYVGRAPSAA TATGFYQVHV KEQSELVQKA LQRDPVNYPF
//
