ID A0A1U7Z9X8_NELNU Unreviewed; 753 AA.
AC A0A1U7Z9X8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN Name=LOC104591930 {ECO:0000313|RefSeq:XP_010249384.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010249384.1};
RN [1] {ECO:0000313|RefSeq:XP_010249384.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_010249384.1; XM_010251082.2.
DR AlphaFoldDB; A0A1U7Z9X8; -.
DR STRING; 4432.A0A1U7Z9X8; -.
DR GeneID; 104591930; -.
DR KEGG; nnu:104591930; -.
DR eggNOG; KOG1175; Eukaryota.
DR InParanoid; A0A1U7Z9X8; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IBA:GO_Central.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006085; P:acetyl-CoA biosynthetic process; IBA:GO_Central.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR HAMAP; MF_01123; Ac_CoA_synth; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703}.
FT DOMAIN 120..180
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 187..575
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 637..715
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 753 AA; 83595 MW; 20638FA96B33F84D CRC64;
MAQSHLLTHL RLFSYAPPAI ACQSPLLSSN LLFINRSFSS PASGRSFSFS MATPDGAKKL
KTSNYLRHVE SLAVLPSGAG KISHLNAVIL GEALASEEND LVFPSEEFSR QALVPSPMKY
MEMYRRSIED PAGFWSEIAS EFYWKQKWGT TVYSENLDVR KGPIKIEWFK GGITNICYNA
LDRNIEAGNG DKIAIYWEGN DLGQDGSLTY SSLLEKVCQL ANYLKDIGVR KGDAVVIYLP
MLMELPIAML ACARIGAIHS VVFAGFSADS LAQRIVDCKP KAVITCNAVR RGPKVIHLKD
IVDDALAESA KSGVSVDVCL TYENQSAMNR HDTKWQKGRD IWWQDTIPEY PTTCEIEWVD
AEDPLFLLYT SGSTGKPKGV LHTTGGYMIY TATTFKYAFD YKPPDIYWCT ADCGWITGHS
YVTYGPLLNG ATVIVFEGVP SYPDPGRCWN IVDKYKVTLF YTAPTLVRSL MREGDEYVTR
YSRKSLRVLG SVGEPINPSA WRWFFNIVGD SRCPISDTWW QTETGGFLIT PLPGAWPQKP
GSATFPFFGV QPVIVDEKGA EIEGECSGYL CIKSSWPGAF RTLYGDHERY ETTYFKPFPG
YYFSGDGCSR DKDGYHWLTG RVDDVINVSG HRIGTAEVES ALVSHPQCAE AAVVGVEHEV
KGQGIYAFVT LVDGVPYSEE LRKSLTLAVR KQIGPFAAPD KIHWAPGLPK TRSGKIMRRI
LRKIASRQLD ELGDTSTLAD PNVVDQLIAL SDC
//
