ID A0A219C6Y1_ACIBA Unreviewed; 547 AA.
AC A0A219C6Y1;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=AMP-binding protein {ECO:0000313|EMBL:MBD0219776.1};
DE SubName: Full=Acetyl-CoA synthetase {ECO:0000313|EMBL:SSI52796.1};
DE EC=6.2.1.1 {ECO:0000313|EMBL:SSI52796.1};
GN Name=acsA_2 {ECO:0000313|EMBL:SSI52796.1};
GN ORFNames=AYR68_11230 {ECO:0000313|EMBL:AML67586.1}, B7L45_07845
GN {ECO:0000313|EMBL:ARG01651.1}, B9W25_06565
GN {ECO:0000313|EMBL:PRN35874.1}, CBL15_06500
GN {ECO:0000313|EMBL:AWW84650.1}, CTZ19_06985
GN {ECO:0000313|EMBL:ATU55924.1}, D8O08_013910
GN {ECO:0000313|EMBL:QBF37358.1}, DLI71_04825
GN {ECO:0000313|EMBL:QFX71015.1}, EA720_017075
GN {ECO:0000313|EMBL:QBH55259.1}, FDN00_08095
GN {ECO:0000313|EMBL:QCP41831.1}, FE003_06920
GN {ECO:0000313|EMBL:QCT15489.1}, IAG11_07715
GN {ECO:0000313|EMBL:MBD0219776.1}, SAMEA4394745_02456
GN {ECO:0000313|EMBL:SSI52796.1};
OS Acinetobacter baumannii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=470 {ECO:0000313|EMBL:MBD0219776.1, ECO:0000313|Proteomes:UP000634608};
RN [1] {ECO:0000313|EMBL:AML67586.1, ECO:0000313|Proteomes:UP000070545}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH859 {ECO:0000313|EMBL:AML67586.1,
RC ECO:0000313|Proteomes:UP000070545};
RA Feng Y., Hua X., Yu Y.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PRN35874.1, ECO:0000313|Proteomes:UP000237823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KUFAR57 {ECO:0000313|EMBL:PRN35874.1,
RC ECO:0000313|Proteomes:UP000237823};
RA Nasser K., Habibi N., Khan M.W., Purohit P., Al-Obaid I., Dhar R.,
RA Al-Fouzan W., Mustafa A.S.;
RT "Comparison of Acinetobacter baumannii whole genome sequences from two
RT major hospitals in Kuwait.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ARG01651.1, ECO:0000313|Proteomes:UP000192723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAA14 {ECO:0000313|EMBL:ARG01651.1,
RC ECO:0000313|Proteomes:UP000192723};
RA Yoon E.-J., Kim J.O., Yang J.W., Kim H.S., Lee K.J., Jeong S.H., Lee H.,
RA Lee K.;
RT "Multiplied blaOXA-23-transposons in the genome of Acinetobacter spp. as an
RT adaptive mechanism for bacteria encountering carbapenems.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AWW84650.1, ECO:0000313|Proteomes:UP000249421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH731 {ECO:0000313|EMBL:AWW84650.1,
RC ECO:0000313|Proteomes:UP000249421};
RA Hua X., Yu Y.;
RT "The evolution of oxa-23 in Acinetobacter baumanni.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:ATU55924.1, ECO:0000313|Proteomes:UP000229219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab4568 {ECO:0000313|EMBL:ATU55924.1,
RC ECO:0000313|Proteomes:UP000229219};
RA Liu X.;
RT "Genome analysis of an Acinetobacter baumannii outbreak in hospital ICU in
RT China.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:SSI52796.1, ECO:0000313|Proteomes:UP000262697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4300STDY6542375 {ECO:0000313|EMBL:SSI52796.1,
RC ECO:0000313|Proteomes:UP000262697};
RG Pathogen Informatics;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Proteomes:UP000268766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TG60155 {ECO:0000313|Proteomes:UP000268766};
RA Sahl J.W.;
RT "GWAS and RNA-Seq identify cryptic mechanisms of antimicrobial resistance
RT in Acinetobacter baumannii.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:QBH55259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TG60155 {ECO:0000313|EMBL:QBH55259.1};
RA Sahl J.W.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:QBF37358.1, ECO:0000313|Proteomes:UP000270202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VB31459 {ECO:0000313|EMBL:QBF37358.1,
RC ECO:0000313|Proteomes:UP000270202};
RA Veeraraghavan B., Vijayakumar S., Neeravi A., Venkatesan M.;
RT "Carbapenem resistant Acinetobacter baumannii_VB31459_hybrid assembly.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:QBH55259.1, ECO:0000313|Proteomes:UP000268766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TG60155 {ECO:0000313|EMBL:QBH55259.1,
RC ECO:0000313|Proteomes:UP000268766};
RA Sahl J.;
RT "Comparative genomics and transcriptomics of Acinetobacter baumannii.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:QCP41831.1, ECO:0000313|Proteomes:UP000298622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VB33071 {ECO:0000313|EMBL:QCP41831.1,
RC ECO:0000313|Proteomes:UP000298622};
RA Veeraraghavan B., Vijayakumar S., Vasudevan K., Narasimman V.,
RA Venkatesan M.;
RT "Carbapenem resistant Acinetobacter baumannii_VB33071_hybrid assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:QCT15489.1, ECO:0000313|Proteomes:UP000300722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB364 {ECO:0000313|EMBL:QCT15489.1,
RC ECO:0000313|Proteomes:UP000300722};
RA Huang W., Wang G., Yin C., Chen D., Dhand A., Chanza M., Dimitrova N.,
RA Fallon J.T.;
RT "Optimizing a Whole-Genome Sequencing Data Processing Pipeline for
RT Precision Surveillance of Healthcare-Associated Infections.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:QFX71015.1, ECO:0000313|Proteomes:UP000325982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6507 {ECO:0000313|EMBL:QFX71015.1,
RC ECO:0000313|Proteomes:UP000325982};
RA Paul V., Sankar M.J., Gaind R., Ray P., Gautam V., Biswal M., Datta S.,
RA Walia K., Kreiswirth B., Evans S., Fowler V., Patel R., Chambers H.C.,
RA Bonomo R.A., Hujer K.M., Huker A., Adams M., Clarke T.H., Sutton G.,
RA Nierman W.C., Nelson K.E., Fouts D.E.;
RT "10 Multi-Drug Resistant Acinetobacter Baumannii Strains for ARLG-ICMR From
RT India.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:MBD0219776.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A86 {ECO:0000313|EMBL:MBD0219776.1};
RA Abouelfetouh A., Mattock J., Turner D., Li E., Evans B.A.;
RT "Diversity of carbapenem-resistant Acinetobacter baumannii and
RT bacteriophage-mediated spread of the Oxa23 carbapenemase.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP014539; AML67586.1; -; Genomic_DNA.
DR EMBL; CP020579; ARG01651.1; -; Genomic_DNA.
DR EMBL; CP024613; ATU55924.1; -; Genomic_DNA.
DR EMBL; CP021321; AWW84650.1; -; Genomic_DNA.
DR EMBL; JACSVK010000014; MBD0219776.1; -; Genomic_DNA.
DR EMBL; NEPB01000009; PRN35874.1; -; Genomic_DNA.
DR EMBL; CP035930; QBF37358.1; -; Genomic_DNA.
DR EMBL; CP036283; QBH55259.1; -; Genomic_DNA.
DR EMBL; CP040084; QCP41831.1; -; Genomic_DNA.
DR EMBL; CP040425; QCT15489.1; -; Genomic_DNA.
DR EMBL; CP045528; QFX71015.1; -; Genomic_DNA.
DR EMBL; UFDJ01000012; SSI52796.1; -; Genomic_DNA.
DR RefSeq; WP_000853316.1; NZ_WQMN01000016.1.
DR KEGG; abw:BL01_17195; -.
DR OMA; RDHYGQT; -.
DR Proteomes; UP000070545; Chromosome.
DR Proteomes; UP000192723; Chromosome.
DR Proteomes; UP000229219; Chromosome.
DR Proteomes; UP000237823; Unassembled WGS sequence.
DR Proteomes; UP000249421; Chromosome.
DR Proteomes; UP000262697; Unassembled WGS sequence.
DR Proteomes; UP000268766; Chromosome.
DR Proteomes; UP000270202; Chromosome.
DR Proteomes; UP000298622; Chromosome.
DR Proteomes; UP000300722; Chromosome.
DR Proteomes; UP000325982; Chromosome.
DR Proteomes; UP000634608; Unassembled WGS sequence.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:SSI52796.1}.
FT DOMAIN 43..391
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 450..527
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 547 AA; 61366 MW; 44C8D2A585BAA4C6 CRC64;
MKTLAEAYQQ FDLTRLIEEQ LVGHPQAINA YVECCERYVG KYKTALIWEG KNGQAEHYTF
EQLAELSGKL ANFFKAQGIQ AGDCIAGLLP RTPELLITIL ATWRIGAIYQ PLFTAFEAKS
IDHRITTAQT KLIVTNDEQR PKLNTLNVPV IVTVHQTGLL SEHDFDFWQS LQRYSEQCEP
VNRSFDDDFL MMFTSGTTGL AKSVPVPLKA ILAFKGYMTH AVDLREEDMF WNLADPGWAY
GLYYGITGPL SLGHGIIMDE RSFNVDQAIE LIKKYKVSNL TGSPTAFRMF FGFKEKFDPS
IKQHLRVVSS AGEPLTPEVV NWFKQDLEVN IFDQYGQTEL GMVIANHHAL EHPLKVGSAG
FAIPGHRFAV LDQNYQELPT GGVGILAMDS EQSPLMWFKG YGGNNRKAFV GKYYLTGDTV
TLNEHGGIDF VGRADNVITT SGYRVGPFDV ESTLLECEAV LESAVIGKPD PERTEIVKAF
VVLKPAYQAC ETLKDKLQQY VRNRLSRHAY PKEIEFVDSL PKTTSGKIQR GLLKQQEIAK
MQQAYAS
//
