ID A3P518_BURP0 Unreviewed; 5993 AA.
AC A3P518;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Polyketide synthase PksL {ECO:0000313|EMBL:ABN93006.1};
GN OrderedLocusNames=BURPS1106A_A1394 {ECO:0000313|EMBL:ABN93006.1};
OS Burkholderia pseudomallei (strain 1106a).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=357348 {ECO:0000313|EMBL:ABN93006.1, ECO:0000313|Proteomes:UP000006738};
RN [1] {ECO:0000313|Proteomes:UP000006738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1106a {ECO:0000313|Proteomes:UP000006738};
RA DeShazer D., Woods D.E., Nierman W.C.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000573; ABN93006.1; -; Genomic_DNA.
DR RefSeq; WP_011857679.1; NC_009078.1.
DR KEGG; bpl:BURPS1106A_A1394; -.
DR HOGENOM; CLU_000022_58_3_4; -.
DR Proteomes; UP000006738; Chromosome II.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 9.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 9.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 9.
DR SMART; SM01294; PKS_PP_betabranch; 7.
DR SUPFAM; SSF47336; ACP-like; 9.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 8.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 211..288
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 375..452
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 557..634
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 730..807
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 840..1262
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2329..2759
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3189..3266
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3325..3402
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3498..3920
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5078..5155
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5221..5634
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5839..5913
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 459..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2287..2324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3031..3087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3272..3325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3408..3445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3457..3495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4101..4143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4646..4676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5023..5076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5183..5240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5936..5961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3059..3087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3408..3444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4117..4143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5031..5049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5183..5204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5993 AA; 628357 MW; A6A967BC30424853 CRC64;
MSFDQTLIAD LLDQWLGGQS PDWGRLYPAG RPPIEHAPTY PFARNVYWVH AADRTPEPGL
AAAPARSRDA APPLEAGTMP AAAIAVVGAT AAATATTAVT ARAATTVTNA IDATDATDAT
DATNATTATT AAAATTAVTA SGATGASAAI VLKSAADEAR RHFTPSRERA PVVLRALAPA
AADVADVTDV AASRAAQTQV FDGAAVEAAR LAPDAIGAAL IDSLARRLLV SPQSIGARDA
FDALGVDSLI GQEWLRELNR TYGTSIDGAT LAECGHIGAL ASRIAGARAD AAAPAWVPRA
EPPQRAAQCA PDAGTVSASV LASISTAASI STAASISTAA SITASASTLA SASASASAAA
AAATTHAGDR SAPRITRDAL VHALAASLAK ALYMDVADID IEQPFMEMGL DSIVGVEWVH
QVNRAYGIGI NAIQVYDYPN IVTFAGLVES LTNAGGAAGG DVASGVGGSD SNADTDRDRD
RDRDRDGDVD VDVDGDVNSD GVLTRPTGAA EPARAAAAAT SPTAAEIAAA TAAAASSAIA
VPPTMAKTMA AASAACAPRG ELRREVIDSL AAALYMDASE IDVLQPFVEM GLDSIIGVEW
IHALNRRYGT SIEAIQVYDY PNVEKLTELL SKSIDALSPP HARCESDVLP GEPMTAATAA
NDTNDTNDTN DTNDTNDTNN ANNANNANNA NECGVVAAEA AFAAPPAAPA AAIAAPIAPT
APAPLAAPAA KPATLLDELV ASLAQALFRP ADTIDAERGF EAAGLDPIVA DEWLARVHRR
YGVRVRADEA LACPRIADFA ALVAARQEAG GAQAAGAAPV AAHDARCAAR ASADARAGDR
EPIAIVGMSG RYPGARDLDA YWENLAAGRS AIGEIPASRW DVARHFDAHP ATPGKVYSKW
IGLLDDVDCF DPAFFRISPA EAQEMDPQHR LFLQEGYRAF ENAGYSADTL DGRNCGVYLG
IMNQEYRQLG TGGAVTMLEK SNSFAIGAAR LAYHLNLKGP AIPVDTACSS ALVAIHLACQ
ALRAGEIDMA LAGGVTLYLS PDAYIEMCSS GMLSPDGRCK VFDDSADGFV PGEGVGAVVL
KRLGDAQRDG DPIIATIIGS GINQDGKTNG ITAPNMASQF ELVSGVHGRY GIDPATIRYV
EAHGTGTKLG DPIELTALGD AFRVRTAQTG FCALGSVKSN IGHTSAAAGV AGLHKVLLCM
RHRTLVPTLH FAVPNRHFDF AASPFYVNTE RAPWAPLAAS PRRAAVSSFG FSGTNAHLVV
EEYVHPAAAA PEAGGPFLFP LSARTREQLA AYAAQLRDHV RRAAHEDAGL ADLAYTLQVA
RKPMAERVGL IARTKHELAA LLDAFVDGRD GGDGLIAGRR DRAGGTPPAL SPEALRALVD
AGESRTILQR WALGATIDWA CLYRDLDAAA RPRRIAAPSY PFARERYWLP DPGTRRTPAA
RAARAAGPHP LLREIDSAQS AACFGATLAG DEPFLRDHRI DGRPVMPSSA YLEMVREAAA
RALGEPADAM LVIEGIAWRN PLTVSGGARR LQLRAQAEPG ARALRFDVSS QAAGDAAAEP
LAHCDGVARY VPRAPAGAPD LAALRARLAS GPRAADEAAC AALHARFARL GIEYGATHRV
LLRLRVDGDE ALAELAPAAD GIAQHELHPG TLDAALQPML ALLGERVGDG VPVVPYRIER
AEIHAPTHGA RWAWLRMRPD AHEWIFDVDL CDARGALCVA LRGIAVTAWR RPDEVVRLEP
VWRAAPVEAD LHDERAGLDA QRVVFVCGAH GAPRAWPADG IAPVRYAALA AGAPPGEPDA
LAGWFEAHAL ALFDEVRRLL APGMRQATLV QIVVPAAGPG AILHALGALL QTAHLENPLL
HGQVIAIDDI DAPDLPRRLA RDARRAADTR IRYVNGERQV ACFDEAAAPD GARALPWRQG
GVYLVTGAAG GLARALADAI ARGIGGDAPR ATLVLTGRSP ARDDMRALVA SLCALGVAAD
YRVLDVADRD AVARMVEAIV GEFGALHGVV HCAGVLRDNY LLRKSADEFA QVLAPKVRGT
VNLDRATRDV RSLDFFVTFS SGAGVVGNPG QADYAVANAF MDAFAAHRAS LGAARPGVSV
SIAWPIWQAG GMRIDRQTEA ELERRLAMRP MPTALGLDAL HACLLGASPC PTVIHGARAR
ILALARQGFA APPGFGAADR GTDAPGADAD ADADAVKARV RAAIDGALSA VLKLPDARLR
EPEYFESYGI DSINAIRLTV ELERTFGPLP KTLFFEYRHA DELERYLVSV HGAAVGARIR
SAARGAPAGP ACARAGESGE PPGAPTRPPA SEGGAAGAPR ASAASPLAER DIAVIGMAGR
YPQADDLQQY WDNLRDGRDC IEEIPPHRWD WRKHYDPARG HGAHHSKWGG FINDVDAFDP
LFFNISPKEA VSMDPKERLF LEQVWTAMED AGLRPEDLRR DAQRGTGVYV GLMYENYQLL
AAEAAAAGSD VGMAGGSYAS IANRVSFFLD LRGPSLAVDT MCSSSMVAVH LACRDLLAGE
IGVAIAGGVN LSLHPNKYRM LSAARFMSGD GRCASFGSGG EGYVPGEGVG VLLLKRRADA
ERDGDRILGL IKASAINHGG RSNGYTVPNA AAQGGVIANA IRAAGIDARA INYVEAHGTG
TALGDPIELA GLARGFADSG ANGPCRIGSV KSNIGHCEGA AGIAALTKVL LQLAHRQIVP
SLHSRELNPD LPLDGSRWIV NQSLCDWERV VVDGVPLPRT AGVSAFGAGG TNAHLILSEY
PADACAAPAG VIEPAGRDAH DMHDMHDMHD MHDMHDMHDM HDMHDMHDMH DTHDTHDTHD
THDTHDMHDM HDMHDMHDTQ DMHDTQDMQD MQDMQDMQDM QDALVVPLSA RNAQRLHAYA
QRLRAFVAAH ARGERGAPPR LVDLAFTYQR GRIAMPERLA IVARSLAELE RALTAYVAGQ
RAGDGIYAGR ADRAAAGDAR GAASERTAAD FADRLAARWV AGEAVDWHAL FDGRAPRRIA
APTYPFERGR YWIGASRAAA GAAEAAMRAG GGASRATTAP RALSESGGEV RQPDQTIRRV
RLAPTSSFTA TARAPSPTQA TQATQATQAT QATQATQATQ ATQATQATQA TQATQATQAM
QATQAMQATQ AMQATQATQA TQAAQAAQAA QATQATQATQ ATQATQATQA TQATQASQAT
RAAAAFAPAT KASLEAALRD SLASALFVGV DEIDPSRPFS ELGLDSIVGV EWIRDINRRY
GVSIRTTDVY DYPSVGEFAG LLERLLRESS VAGAPPAPAT EPTMEPTMEP TMEPTMEPVT
APRPEAAGAA PCEPQPDEGR GGAPGNVERI RRELMRSLAD ALFVDIAEID VDRPFAQIGM
DSIVGVEWIK GINQRYRVAL KATDVYDHPT IASIAALVDA RGASAASTAS TASTASTAST
ASTASTASTA STASTASTAS TASPEADVRL AADARIASAA SGAPESEPAR AAHPGAAASR
ARADVAPDAQ AARAEPVPER IAIVGMSGRY PGAPDLDAFW DNLAAGRDAI AEIPPSRWPV
GAFYDPEPGK PGKVYCTRIG LLDDVDRFDP DFFRISPAEA EEMDPQHRLF LQEGYRAIEQ
MGCAPASLSR RKCGVYLGVM NHEYGELAMR HRGAASGIGS SYAIGAARLA YYLNLKGPAI
PVDTACSSAL VATHLACQAL RNGEIDLALV GGVTVYLTPE SYVAMCAAGM LSPEGRCKTF
DDAADGFVPG EGVGALVLKR LADAERDRDP ILGVIVGSGL NQDGRTNGIT APSGSSQTEL
LRDVYRRHRI DPAGIGYVEA HGTGTKLGDP IELTALSAAF GDYTDRRGFC ALGSVKTNIG
HTSAAAGVAS IHKVLLCLAH RELVPTLNYA NPNRHFDFAD SPFYVNTDRR AWDAAGDAPR
RAAVSSFGFS GTNAHVVIEE YRPAAAAAPD ALPPRVIVPL SARHPERLRA YARNLADWLA
QAAARGAPER LAAHLAYTMQ VGRDAMAERV AFVADGRDEL ERQLRRYADT GETSNGVYAG
RAEPHAQASN ALMLDEAFGA AIDGWMRTGK HEPLAKLWAG GFDLDWARLY DGVPAAAMPR
RIAAPTYPFA SGRYWIDVEP DGRAAGPAAD AASPEADSGS DSEHAHEHEH EHEHEHEHEH
EPEPAATLAY LPVWEELPPA QPRAAPDAQA GGVLVVHRGG AWGLVDAIER ECVDGRHAGA
TCVTLDLSGH APSPEGRAWC NAAPDAARLA AWLGEFGPVR AVFFAAGCSE ARHDASGARG
WASAPDAHGE DERALLQLAQ ALMRSQAADA SIEFVVLSLD HHRTDGTPSN PAGGGVAGIA
YAIAQGDHRF RVTNVDVSLD ELRAARHAPA PHPVLAAVLR LAPSDRGALV RLRAGRGYRQ
AFVRLDWAAE AGASGLKQGG VYVMLGGAGR VGRALTRRLI ERYRANVAWI GRSPADSASV
AHALRALGPA GPAPYYAQAD ATDAAQMRRA IEAVRQRHGR IDGAVFCGMV FDANHAIASV
PAHRFDEILD VKARGSRIFY EALAHEPLDF LCYCSSAQSF SFSGAARLGA YAAATTAGDA
IVRSIAPVAA FPVGTIHWGF WETSVEDSAL GSRHLGALSD DEGFACFERF VGQCMRGNPL
REVVCMRASP EVEHLMQVLP GETATLAAPG QPAQPAPLRD APDGAAASEA APPDGAADVS
ADIDAWLARL TFATLRPMLD GPRPARACHA RWWDETLRIF AARGWLRIVD GAPRVIAEPD
AGEHVWRDWA RYRFDTPAAR GRRAQIDLAD VCVRALPDVL AGRLPAADVL FPGGSMERVE
GVYRDNPISD YFNAVQADAL IRHVRAWIDA GRREPIRILE VGAGTGGTTA LALERLRPYA
AAIGEYCFTD VSQAFLQHAQ AAFGARAGYL RTALFDVERP LDAQRMPAGR YDIVIATNVL
HATRQVRGAL RNVKACLRAG GVLLLNEISE KSLFAHLTFG LLEGWWLHED SSLREPGSPV
LAPATWRRLL EDEGFGAIAF AARDAHALGQ QVVCATSDGV IRQRAGEPSG HSSRQGHRNR
QDHQGRQESS THAGEAGAPA PASAGRAGAA PAASPAGTAR EPVVAAIHRA LQQSLKLPEA
RIGDHTPFLD YGIDSILGVR FVDSLKQALD VPLNTAVLFD YPTVERLADF IVATYGARLA
ARGASAAPAS VATASATLAA STASTASTAS TASTASTAST APTAPTAPAA PAAPNAPAAP
AMPAEAVSRD AAAPRAEPAG ARPADIAVIG MAGQFPDAPD VDAFRALLEH ARDGAPGVSG
GMLENRDRFD HAFFHITPDE ADAMHPYQRL VLQESWKALE DAGYNPAALA GARVGVFVGA
EPADYRSTTF SGSSDALIAS RVSYHLNLRG PAYVVNTGCS SGAVAIHLAC ESLRRNESDV
VLACGIFAAM GPRMLGALGQ AGMLSAGGRC RSFDAGADGT AFAEGIGVVA LKRLADAIAD
GDPIHGIVKA SGVNQDGTSN GIMAPNGVAQ EELIVDVYER FGIDPADIRY VEAHGTGTLF
GDAVEANALV RAFRRFTERS AYCALGTVKA TIGHTAAAAG VIGLIRILLS MRARRLPGMP
GLGRANPMID LDASAFSLGL VSREWPAGRD GRPRLAALNT FGHSGTNVHI VVQEPPQARA
RPARAADGPR VAVPLSAMDR EALRRYAARL CERLEAEGAT LCVGDVAHTL RVAREPMAQR
IVLFASTTGE LAALLRAFVD GRDSPCLLDG AVTAAARAAG LDAAQLAQAA RWLAGERVDW
PPAGGTPMRV HLPAYPFAGR RCGAAGWARA EAGASRDCAA AGPCEPPAGV AAAAMTVAAA
GPRVDATPSA AADRARGAAR PAEWLAARVA ARLGVPAARV DRRRSLLDLG LTSQDLVSLA
GQLRDATGEA LLPSVLFDYP TIERLAAHLA DTCPAAFGAA ETAELTETAE TAEPAELTAT
AEPAEPAEPA ETGRAAAGDA ASGPAPGVIA LLERLEGGGL SLEETIYLIE NTK
//
