ID   A4H9L0_LEIBR            Unreviewed;       823 AA.
AC   A4H9L0;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=PhoD-like phosphatase metallophosphatase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LBRM_18_1090 {ECO:0000313|EMBL:CAM38083.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM38083.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM38083.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38083.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM38083.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38083.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FR798992; CAM38083.1; -; Genomic_DNA.
DR   RefSeq; XP_001564032.1; XM_001563982.1.
DR   AlphaFoldDB; A4H9L0; -.
DR   STRING; 5660.A4H9L0; -.
DR   GeneID; 5414568; -.
DR   KEGG; lbz:LBRM_18_1090; -.
DR   VEuPathDB; TriTrypDB:LbrM.18.1090; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_180016800; -.
DR   InParanoid; A4H9L0; -.
DR   OMA; ENWAAFP; -.
DR   Proteomes; UP000007258; Chromosome 18.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd07389; MPP_PhoD; 1.
DR   Gene3D; 3.60.21.70; PhoD-like phosphatase; 1.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR018946; PhoD-like_MPP.
DR   InterPro; IPR038607; PhoD-like_sf.
DR   PANTHER; PTHR33987; CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR33987:SF1; CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        764..785
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          683..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   823 AA;  92145 MW;  17F90172324E0694 CRC64;
     MRRRVVDSEG PKGHVGAAAP IWRSRQSRRT FLAVLLLPIA LLAVGCLLLI LSWNADNGST
     LASVKDFAMD DAWWNPDNRR EEWQRALLYS EQLNLPASHS LAINQVFFIS CNRHDLSQLY
     WAYMAVAAQC EMLSRVNATA APPCRKLYAG LSPLLPTANA AAPSSERHRR IADTDEGAWA
     EEVPLGACGS VYDSPKAAMQ RLRYRWTPQP GLLLDETPPP VHPYPGPERR FQSAPRGAAY
     SASVPVDALI WLGDAIYADK IADGKGTQSL FFHHTNSMVE VGRFWKIQRD ALEYNAFIDS
     CVAGGDNVDW NLHSPNQRFL SAAGSNRTRV MQASPDVYPK VWGTWDDHDM GMNDAGREYP
     DRNSTQAFFL DFLRAPSSDP RWHREGVYGA YRTDFRDVVD DTKGWGTPVR LLMQQLYEHA
     ICAVLLDARS FRDRSNATHA GDAIGAEQWV WFEESLKNYT TPTQDGRERC AMVLIGSGIQ
     FMLDEKPAEN WAAFPRSRDR LLGLLRAYRV ERVAFITGDV HMGELGVDFT EHAIGEVFGY
     PIVEVTSSGL THSSNMYFLP TLMPLLFPSS RRVGLYVGEN FGALRLSIDL HHVPSIRSYL
     TDIERAMGAG AAANESAARS PTPQWRREAR AAVEQVLNAT FTIFSIPNSG QPAYRLNFPL
     SMLTYAHGPA YRDARVNAVH GSVHKKPTTS PTTPEENGDY EAAKGGTERT PSLLLRSTLT
     LTNGTITHIA HYKDTEPAPF ITWSVRQFQY YVFTSFSVSE ALKAMILLDA LVVVMVLLLL
     ILRLYRCLWR QRSSGDRLPH RNVEASPHVS PMMRWRNKTH CGS
//