ID A5I274_CLOBH Unreviewed; 333 AA.
AC A5I274; A7G3X4;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=LacI-family transcriptional regulator {ECO:0000313|EMBL:CAL83139.1};
GN OrderedLocusNames=CBO1601 {ECO:0000313|EMBL:CAL83139.1};
OS Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=441771 {ECO:0000313|EMBL:CAL83139.1, ECO:0000313|Proteomes:UP000001986};
RN [1] {ECO:0000313|EMBL:CAL83139.1, ECO:0000313|Proteomes:UP000001986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger]
RC {ECO:0000313|Proteomes:UP000001986};
RX PubMed=17519437; DOI=10.1101/gr.6282807;
RA Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA White B., Whithead S., Parkhill J.;
RT "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT Hall A and comparative analysis of the clostridial genomes.";
RL Genome Res. 17:1082-1092(2007).
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DR EMBL; AM412317; CAL83139.1; -; Genomic_DNA.
DR RefSeq; WP_011949137.1; NC_009698.1.
DR RefSeq; YP_001254106.1; NC_009495.1.
DR RefSeq; YP_001387489.1; NC_009698.1.
DR AlphaFoldDB; A5I274; -.
DR GeneID; 5185856; -.
DR KEGG; cbh:CLC_1630; -.
DR KEGG; cbo:CBO1601; -.
DR PATRIC; fig|413999.7.peg.1577; -.
DR HOGENOM; CLU_037628_6_2_9; -.
DR Proteomes; UP000001986; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06294; PBP1_MalR-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF121; HTH-TYPE TRANSCRIPTIONAL REPRESSOR CYTR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001986};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 3..57
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 333 AA; 37952 MW; EB2563180D6FDE49 CRC64;
MKVTIKDVAK EAKVSPSTVS RVLSDNPRIS DETKEKVYKV IEKLKYKPNA IARGLVNNKT
RILGVVLPEE AENLLSNPFF IQAMKGISSY AEKREYYITY AFSSNKENEK KHIKDLTTSG
LIEGLLILRP KENDENIKYL KDINFPFVIM GRLKDTEDVL WVDNDNFQAM YNIVNKLIDK
GHTKIALIGA KKELNVCKDR EKGYKVALEM NGISFSEKLV SYGEEFKEKE GYIQMNKLLE
KVKPTAVVAM DDLLAIGAMK ALKEKYLTDL SIVGFNNIPL GEFQKPQLAS VDINGVKLGY
YATKLLIDKI EEVEDTRDHY IVETTFVKRE SFK
//
