ID   A6QS84_AJECN            Unreviewed;       912 AA.
AC   A6QS84;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=PX domain-containing protein {ECO:0000259|PROSITE:PS50195};
GN   ORFNames=HCAG_00240 {ECO:0000313|EMBL:EDN02376.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN02376.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476655; EDN02376.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QS84; -.
DR   STRING; 339724.A6QS84; -.
DR   VEuPathDB; FungiDB:HCAG_00240; -.
DR   HOGENOM; CLU_007739_1_1_1; -.
DR   OMA; KWHSDKT; -.
DR   OrthoDB; 1449900at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06869; PX_UP2_fungi; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR024554; DUF3818_PX-associated.
DR   InterPro; IPR024555; PX-associated.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR047168; YPR097W-like.
DR   PANTHER; PTHR47185; PX DOMAIN-CONTAINING PROTEIN YPR097W; 1.
DR   PANTHER; PTHR47185:SF1; PX DOMAIN-CONTAINING PROTEIN YPR097W; 1.
DR   Pfam; PF12825; DUF3818; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF12828; PXB; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          184..370
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          238..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          802..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          850..887
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..825
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  103966 MW;  E9D75AD6D6305A6A CRC64;
     MENGPPTPAP APPPGQILTG KQEHYLKREL ISLQVRAEIA ELNSPTALRR FGAPFKSDLG
     EIAPIDSELP ILRFIFVQHV RKFPFLDQAK EKEFWQDKLQ TFLESFANKH ISSSEDRHEE
     TKRRKLALKC EKLVELMMVS GIPTASGYEE RIRFSEMEVV DRSANEQGLL VNIPDGHAIH
     GWDVNVAGAR TTLVKRTVRY HQHAEFILRV KQHGKPDRYV GRRFGEFAKL HKRLRTEMPG
     KILPPLPRKN KGSVSSTILG GGDDDASSDS SVSTQDANFT DDSRSARTLT VNNADHHRSS
     SRSSVTKKLR SATVTPRPST GDLKTEVTVS LYRETQRVSL RAFLRTLLQN PRIAESKALE
     EFLTADPITL NEEELMDIQR RKDLDAKRVE EQRQFYEIAR KRAQELDVYM EQFRQDIVEN
     NGLTKLFHEI RVKNSVEELS PQYQKFAEWL RIEVAAMIYH LFLAEDNSPE LFAQAKRIHS
     LVPYTIMKNV IRIANPAAVM SGVLDLFLAQ PFGSRSLLQR IFSLAIHDGI KTFQRSIDTL
     SAKIEDPVLV NKLRAFTAAD EQVKDELRRE AKEEDVDIVV AILRSEYIEP ELSPAQIEKV
     FNSYVAWVNT VENVDMQMQQ GAHWFAYLKQ LLKLLTRQRD KAMMLSVIEE PVTLQLFRDL
     FTIFYEPLVR VYKSANVYSS ITDFAEFADD AIAVIESAQR QDVSADPNQT VQAFIDLCAR
     HQHSFYKFVH EVHLHDNGLF DALMGWLEDI LHFLRHGPRS GGKLDMNALF RGAVAVGQID
     PELAMKEIDL LVKWHADRKK WHHHKTRQKM AAEGSGTTAD SEMPGSATFR GSDFGLDEAD
     LEDLAIDDMA SHSSDEDSAE DDLDPISVER KRRSKRQARL RRTAGEPVKP EIREILKMRE
     SFGAMVRTVL AD
//