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Database: UniProt/TrEMBL
Entry: A6V4G2_PSEA7
LinkDB: A6V4G2_PSEA7
Original site: A6V4G2_PSEA7 
ID   A6V4G2_PSEA7            Unreviewed;       741 AA.
AC   A6V4G2;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ABR86332.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ABR86332.1};
GN   OrderedLocusNames=PSPA7_2583 {ECO:0000313|EMBL:ABR86332.1};
OS   Pseudomonas aeruginosa (strain PA7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=381754 {ECO:0000313|EMBL:ABR86332.1, ECO:0000313|Proteomes:UP000001582};
RN   [1] {ECO:0000313|EMBL:ABR86332.1, ECO:0000313|Proteomes:UP000001582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA7 {ECO:0000313|EMBL:ABR86332.1,
RC   ECO:0000313|Proteomes:UP000001582};
RA   Dodson R.J., Harkins D., Paulsen I.T.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP000744; ABR86332.1; -; Genomic_DNA.
DR   RefSeq; WP_012075453.1; NC_009656.1.
DR   ProteinModelPortal; A6V4G2; -.
DR   EnsemblBacteria; ABR86332; ABR86332; PSPA7_2583.
DR   KEGG; pap:PSPA7_2583; -.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   Proteomes; UP000001582; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001582};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ABR86332.1}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       350    350       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       552    552       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     547    547       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        420    420       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   741 AA;  81664 MW;  AA62275196699886 CRC64;
     MSIRSKITYT FTDEAPALAT YSLLPIVKAF AASAGIDVET SDISLAGRIL ANFADRLEAD
     QRIEDDLARL AVLATSPDAN IIKLPNISAS VPQLKGAIAE LQALGYKVPD FPEDPQTDEE
     KEVRARYAKI LGSAVNPVLR EGNSDRRAPA AVKAYARKHP HSMGKWSMAS RSHADYMRGG
     DFFSSEQSIT MAKAGDVRIE FVGKDGKVEV KKQLSLQEGE VLDSMFMSCG KLRDFFEKTL
     QDCKETGVMW SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KWGQLFEELG VNPNNGISSV
     YDKIKSLPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRNS
     GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD PTTMGSVPNV GLMAQKAEEY
     GSHDKTFEMT ADGTMRVVLA DGTVLMQHEV ETGDIWRACQ TKDAPIRDWV KLAVTRARQS
     DTPAIFWLDP ERAHDRELRK KVELYLKDHD LTGLDISIMG YNEAIRVSME RLIRGKDTIS
     VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
     WDSLGEFLAL AVSLEETGIK TGNAKAKLLG KALDEATGKL LDNNKSPSRK VGDIDNRGSH
     FYLAMYWAQA LAAQDEDAEL KAHFAPLAKA LTEQEATIVA ELNAVQGKPA EIGGYYRSNP
     ELTSKVMRPS ATFNAAIDSL A
//
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