ID A7RK60_NEMVE Unreviewed; 451 AA.
AC A7RK60;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO48191.1};
GN ORFNames=NEMVEDRAFT_v1g234104 {ECO:0000313|EMBL:EDO48191.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO48191.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO48191.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; DS469515; EDO48191.1; -; Genomic_DNA.
DR RefSeq; XP_001640254.1; XM_001640204.1.
DR AlphaFoldDB; A7RK60; -.
DR STRING; 45351.A7RK60; -.
DR EnsemblMetazoa; EDO48191; EDO48191; NEMVEDRAFT_v1g234104.
DR GeneID; 5520342; -.
DR KEGG; nve:5520342; -.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_22_0_1; -.
DR InParanoid; A7RK60; -.
DR OMA; GGTQCPL; -.
DR OrthoDB; 2900138at2759; -.
DR PhylomeDB; A7RK60; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047442; F:17-alpha-hydroxyprogesterone aldolase activity; IBA:GO_Central.
DR GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004508; F:steroid 17-alpha-monooxygenase activity; IBA:GO_Central.
DR GO; GO:0042446; P:hormone biosynthetic process; IBA:GO_Central.
DR GO; GO:0042448; P:progesterone metabolic process; IBA:GO_Central.
DR CDD; cd11027; CYP17A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24289; STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE; 1.
DR PANTHER; PTHR24289:SF1; UNSPECIFIC MONOOXYGENASE; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01683; EP450ICYP1A.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
SQ SEQUENCE 451 AA; 51179 MW; 8610822CF1564273 CRC64;
MLQMGPTPHL GLTELAKSYG EVFRLKVGSH RIVVVNSIEA AREALVRRAN DFAGRPMLYT
ASLISRNGTD IAFGDFGPLW KQQRKIAHSA LRMFGSGLKP LEEKITVEAD ELIKRLSLVE
GRAHNPKDDV NLAVLNIICS FVFGSRYDMD DPEFHTVVDY TEQFVQGFRA ASLVDYFPWL
RHLPNKGLRQ IKEACQNRDV VLQKKYQEHL VTYEHGVIRD LTDALLSANK ASQEESAYLP
MTEDHIIMTM NDIFSAGLET TATSILWSLV YLIRNPKVQE QLHQQIDEVV GRDRAPELSD
RENLPLIEAT IAEVLRSSSL VPLLFPHSTT TDTHLRGYEV PKDTIVLFNV WNMHHDPQRW
SNPDEFDPTR FLDDKGKFIC PATLSYLPFS AGRRVCLAES LGKMQLFLFI SRLLHKFRFS
VPPNGHPPSL EGVFGASLCP KPFRIVVEKR S
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