ID A8N0K6_COPC7 Unreviewed; 590 AA.
AC A8N0K6;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN ORFNames=CC1G_04427 {ECO:0000313|EMBL:EAU93448.2};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU93448.2, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU93448.2, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00006457}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU93448.2}.
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DR EMBL; AACS02000001; EAU93448.2; -; Genomic_DNA.
DR RefSeq; XP_001828456.2; XM_001828404.2.
DR AlphaFoldDB; A8N0K6; -.
DR STRING; 240176.A8N0K6; -.
DR GeneID; 6004879; -.
DR KEGG; cci:CC1G_04427; -.
DR VEuPathDB; FungiDB:CC1G_04427; -.
DR eggNOG; KOG1342; Eukaryota.
DR HOGENOM; CLU_007727_0_2_1; -.
DR InParanoid; A8N0K6; -.
DR OMA; EHRWDKH; -.
DR OrthoDB; 1327607at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR003084; His_deacetylse_1.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR PRINTS; PR01271; HISDACETLASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT DOMAIN 34..322
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 377..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 63864 MW; A444581ABBE13AA4 CRC64;
MGDKWTPVEG ESQKKRVCYF YDSDIGGFHY GPGHPMKPTR IRMCHSLVMN YGLYKKMEIF
RAKPATKREM TQFHSDEYVE FLSKITPNNM NSFVKEQHKY NVGDDCPVFD GLFEYCSISA
GGSMEGAARL SRDKCDIAIN WAGGLHHAKK SEASGFCYVN DIVLGILELL RYHNRVLYID
IDVHHGDGVE EAFYTTDRVM TVSFHKYGEY FPGTGELRDV GIMKGKYYSL NFPLRDGISD
ENYKSVFEPV IRSVMETYDP SAIVLQCGTD SLSGDKLGCL NLSMKGHANC VKFVKSFNKP
LLLLGGGGYT MRNVSRAWAY ETGLAAGVEL NPEIPVNEYY EYFGPDYQLD VKSSNTDDLN
TPAYLDRVKR IVLENLRHTQ GPPSVQMTDI PSMPIDADID DPNQDEDMVD PNDRRPMRLL
DSRRQADGEL SDSDDEGEGG RRDIASHKDR ESNGEGAGHK FGMGVGIMAS SSAATHGAGP
SGHTTAAQIL SAPKADAPMD VDTPTSETGS APVTEGKSSE VNGGGGASAG AVAASAGPSS
ASGQPAAPAA EPAKEDKDTA MAVEEPSEPK PSEPASSTAA AAPAPTTSTT
//
