ID A9RTW1_PHYPA Unreviewed; 2180 AA.
AC A9RTW1;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPA_001660 {ECO:0000313|EMBL:PNR63235.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218 {ECO:0000313|EMBL:PNR63235.1};
RN [1] {ECO:0000313|EMBL:PNR63235.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c1_35880V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2] {ECO:0000313|EMBL:PNR63235.1, ECO:0000313|Proteomes:UP000006727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004 {ECO:0000313|EnsemblPlants:Pp3c1_35880V3.1,
RC ECO:0000313|Proteomes:UP000006727};
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3] {ECO:0000313|EnsemblPlants:Pp3c1_35880V3.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; ABEU02000001; PNR63235.1; -; Genomic_DNA.
DR RefSeq; XP_001757495.1; XM_001757443.1.
DR STRING; 3218.A9RTW1; -.
DR PaxDb; 3218-PP1S28_172V6-1; -.
DR EnsemblPlants; Pp3c1_35880V3.1; Pp3c1_35880V3.1; Pp3c1_35880.
DR EnsemblPlants; Pp3c1_35880V3.2; Pp3c1_35880V3.2; Pp3c1_35880.
DR EnsemblPlants; Pp3c1_35880V3.3; Pp3c1_35880V3.3; Pp3c1_35880.
DR EnsemblPlants; Pp3c1_35880V3.4; Pp3c1_35880V3.4; Pp3c1_35880.
DR Gramene; Pp3c1_35880V3.1; Pp3c1_35880V3.1; Pp3c1_35880.
DR Gramene; Pp3c1_35880V3.2; Pp3c1_35880V3.2; Pp3c1_35880.
DR Gramene; Pp3c1_35880V3.3; Pp3c1_35880V3.3; Pp3c1_35880.
DR Gramene; Pp3c1_35880V3.4; Pp3c1_35880V3.4; Pp3c1_35880.
DR eggNOG; KOG0951; Eukaryota.
DR HOGENOM; CLU_000335_2_1_1; -.
DR InParanoid; A9RTW1; -.
DR OMA; QTEIQYY; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000006727; Chromosome 1.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0000388; P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11); IBA:GO_Central.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006727}.
FT DOMAIN 520..703
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 729..932
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1366..1542
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1576..1785
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 21..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..244
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2180 AA; 247097 MW; BFF095E8D579549D CRC64;
MAHLGGGAEA HARFKQYEYR ANSSLVLTTD TRPRDTHEPT GEPESLYGRI DPRSFGDRVY
HGRANDLEEK LTKHRRKREV KEKEKGSNAE GLKKARKRLR GMQEESVLSI VDDGMYRPKT
KETRAAYEAL LSTIQQQFGD QPQDILRGAA DEVLGVLKND RFRDLDKKKE IEKLLNSMSN
ERFAQLVAIG KLISDYSEGG DAGAEGAGEA LDDDIGVAVE FEEEEEEDES DYDEVQEESD
GEEGDGQDTR QASAMQMGGQ DDEDMEEADE GLNVQDIDAY WLQRKISQAH GDIDPQQSQK
LAEDVLSKLA EGDDREVENR LVILLDYDKF DLIKLLLRNR LKVVWCTRLA RAEDEDARKK
IEEEMSNGGP VLAGILEQLH ATRATAKERQ KNLERSIREE AKKLRDDGGE AADRGRRKDR
EVGVGGGESG WLKGQRQLLD LEQLTFHQGG LLMANKRCEL PPLSYRTPKK GYEEVHVPHL
KPKPFAEGEE LVKISDMPDW AQPAFKGMKS LNRVQSKVYE TALFTSENLL LCAPTGAGKT
NVAMLTILHE LGLRKQLDGT FDLSSFKIVY VAPMKALVAE MVGNFSERLE PYGVTVRELT
GDATLSRGQI EETQIIVTTP EKWDIITRKS GDRTYTQMVK LLIIDEIHLL HDNRGPVLES
IVARTVRQIE TTQEMIRLVG LSATLPNYED VALFLKVDEK KGLFYFDNSY RPCPLAQQYI
GVTVRKPLQR FQLMNDICYE KVMEVAGKHQ VLIFVHSRKE TAKTARAIRD AALANDTLGR
FLKEDGASRE ILQKENDVVK NNDLKNLLPY GFAIHHAGMG RADRTLVEDL FGDGHIQVLV
STATLAWGVN LPAHTVIIKG TQIYNPEKGA WTELSPLDVM QMLGRAGRPQ FDTYGEGIII
TGHSELQYYL SLMNQQLPIE SQYISKLADN LNAEIVLGSV QDAREACDWL GYTYLYIRML
KNPTLYGVSR EALEADPSLE ERRADLVHSA AIVLDRNNLV KYDRKSGYFQ VTDLGRIASY
YYISHGSMAT YNEHLKPTMG DIELCRLFSL SEEFKFVTVR EEEKMELAKL LDRVPIPVKE
SLEEPSAKIN VLLQAYISQL KLEGLSLTSD MVFITQSAGR LMRALFEIVL KRGWAQLAEK
ALTLCKMVSR RMWSSQTPLR QFKGIPNDIL SKVEKKDLPW ERYYDLSSQE IGELIRYPKM
GKSIHRYIHQ FPKLELAAHV QPITRSVLKV DLTITPDFQW DEKYHGYVES FWVIVEDNDG
ENILHHEYFL LKMQYVEEDH NLSFTVPIYE PLPPQYFVRV VSDRWLGSET VLPVSFRHLI
LPEKYPPPTE LLDLQPLPVS ALRNPSYEVL YQKFRHFNPI QTQVFPVLYN TDDNVLVAAP
TGSGKTICAE FAVLRMLQKG EAGGRCVYIA PVEALAKERL RDWESKFGRT LGVRVVELTG
ETATDMKLLE KGQIIISTPE RWDVLSRRWK QRKHVQQVSL FVVDELHLIG GEGGPVLEVI
VSRMRYIGSQ TENQIRIVAL STSLANAKDL GDWIGASSHG LFNFPPGVRP VPLEIHIQGV
DIANFEARMQ AMTKPTYTAI VHHVKKQEPA LIFVPTRKHA RLTALDLVTY ATVNGNGKSP
FLHCAEADLA PFLSKVKDEA LIHALLQGIG YLHEGLSAIE QEVVTSLLTA EAIQVCVATS
SMCWGMTLSA HLVVVMGTQF YDGRENAHTD YPITDLLQMM GRASRPQVDT SGKCVILCHA
PRKEYYKKFL YEPFPVESHL DHYLHDHLNA EVVVRTIENK QDAVDYLTWT FMYRRLTQNP
NYYNLQGVSH RHLSDHLSEL VESTLSDLES SKCVAIEDDM DLSPLNLGMI AAYYYISYTT
IELFSSSLTA KTKLKGLLEI LSNASEYTRL PMRPGEDELI RKLVMHQRFS MDKPKFTDPH
VKANALLQAH FARHSVSGNL ALDQRDILID ASRLIQAMVD VISSSGWLHP ALAAMELSQM
VTQGLWERDS YLLQLPYFTK DLAKKCADNP DKPIQTVFDL VEMEDDERRE LLQMSDAQLM
EIARVCNRFP NIDLAHEVLD NDDISPGDTV TLQVTLEREM EGRQELSPVD APRFPKPKEE
GWWLVVCEPK SNQLLAIKRV SLQRRSKVKL DFTAPNEVGR KTYTLFFMCD AYLGCDQENE
FTIDVKEGVD AEDDGNAMEE
//
