ID B0TB64_HELMI Unreviewed; 442 AA.
AC B0TB64;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Hexokinase, putative {ECO:0000313|EMBL:ABZ83791.1};
GN ORFNames=HM1_0763 {ECO:0000313|EMBL:ABZ83791.1};
OS Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Heliobacteriaceae;
OC Heliomicrobium.
OX NCBI_TaxID=498761 {ECO:0000313|EMBL:ABZ83791.1, ECO:0000313|Proteomes:UP000008550};
RN [1] {ECO:0000313|EMBL:ABZ83791.1, ECO:0000313|Proteomes:UP000008550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51547 / Ice1 {ECO:0000313|Proteomes:UP000008550};
RX PubMed=18441057; DOI=10.1128/JB.00299-08;
RA Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T.,
RA Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT "The genome of Heliobacterium modesticaldum, a phototrophic representative
RT of the Firmicutes containing the simplest photosynthetic apparatus.";
RL J. Bacteriol. 190:4687-4696(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation. {ECO:0000256|ARBA:ARBA00004921}.
CC -!- PATHWAY: Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR EMBL; CP000930; ABZ83791.1; -; Genomic_DNA.
DR RefSeq; WP_012282313.1; NC_010337.2.
DR AlphaFoldDB; B0TB64; -.
DR STRING; 498761.HM1_0763; -.
DR KEGG; hmo:HM1_0763; -.
DR eggNOG; COG5026; Bacteria.
DR HOGENOM; CLU_014393_5_3_9; -.
DR OrthoDB; 6383434at2; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000008550; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008550};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..204
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 210..436
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 442 AA; 47527 MW; 4CE8EC8526275282 CRC64;
MRRWALAAKE LEDSLYLPAT ALDAMASRFQ QAMEQGLTGK GGSLKMLPSY LAGPTGKERG
TFLALDFGGT NVRVALIELA GGQSRVLNRL SRPVRAADGR YDYSRQSATA EELFDFLASL
IAETIGDHQG RFYLGHTFSF PARQENIGQA TLIRWAKEFH TTGVEGHDVG QLLSDALARK
GLKERVIPAA IINDTVGTLL TATYSDRHTR IGSIIGTGHN SCYLDRFVPA FQAPMVINME
SGNFDGAPAS VFDERLDGQS AQPGAQRLEK MVSGLYLGEL LRLILLELIQ TKGLFGGQAS
PVLERPYSLS AADLSDLQAD GSAELSRVGD WLQARAAIEA SEREERRLLQ RIAAATACRS
ARLVAATYLA VLRHEDPALT LRHTIAIDGS LYEKMPGYAG ALERALAELL AEKAGQVSVR
LVKNGSEVGA AIAAAIVAAA SD
//
