ID B3MCM2_DROAN Unreviewed; 1486 AA.
AC B3MCM2;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=PHD-type domain-containing protein {ECO:0000259|PROSITE:PS50016};
GN Name=Dana\GF12873 {ECO:0000313|EMBL:EDV36256.1};
GN Synonyms=dana_GLEANR_12890 {ECO:0000313|EMBL:EDV36256.1};
GN ORFNames=GF12873 {ECO:0000313|EMBL:EDV36256.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV36256.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV36256.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH902619; EDV36256.1; -; Genomic_DNA.
DR RefSeq; XP_001959434.1; XM_001959398.2.
DR SMR; B3MCM2; -.
DR STRING; 7217.B3MCM2; -.
DR EnsemblMetazoa; FBtr0117573; FBpp0116065; FBgn0089907.
DR GeneID; 6495719; -.
DR KEGG; dan:6495719; -.
DR eggNOG; KOG1245; Eukaryota.
DR eggNOG; KOG4443; Eukaryota.
DR HOGENOM; CLU_001919_0_0_1; -.
DR InParanoid; B3MCM2; -.
DR OMA; PEAIHWI; -.
DR OrthoDB; 2912893at2759; -.
DR PhylomeDB; B3MCM2; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblMetazoa.
DR GO; GO:0008230; C:ecdysone receptor holocomplex; IEA:EnsemblMetazoa.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:EnsemblMetazoa.
DR GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0042393; F:histone binding; IEA:EnsemblMetazoa.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:EnsemblMetazoa.
DR GO; GO:0018990; P:ecdysis, chitin-based cuticle; IEA:EnsemblMetazoa.
DR GO; GO:0035076; P:ecdysone receptor-mediated signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR CDD; cd21997; HMG_KMT2C-like; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15510; PHD2_KMT2C_like; 1.
DR CDD; cd15512; PHD4_KMT2C_like; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF00628; PHD; 4.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 7.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50016; ZF_PHD_2; 5.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 203..253
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 250..301
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 334..395
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 528..581
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 578..628
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1226..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1486 AA; 165245 MW; B3FF10470078A2F0 CRC64;
MSINVVANME EKPTSDELPY FPENFPGKVC CLCNLGEKSA LGQGAILQLK APAPNDLKEK
YPTDRLKEDG CRPFYGTKQT PASTSDCNYE LDKIGQAEIV HPAEFLDEGF IYVHRMCVMW
SLRKSQITDA DAAYFASHFA EFLEQKCNFC GRYGASINCK MKCRQVHHWP CAAAAGCLLI
LESFTVFCTE HLSQVILICS DNNVECLTCS SLGDLSKLIM CSTCGDHFHS TCVGLANLPD
TRSGWNCARC TKCQICRVQD SNDLKYVKCE QCQKIYHASC LRPVISAIPK YGWKCNRCRV
CTDCGSRTPG GGSSSRWHSH YTICDSCYQQ RNKGFSCPIC QKAYRAASHK EMVKCSWCNK
FVHSTCDEEA DLTAYHKKKE LNPDYDYVCP NCKSSPAGPG QSQQAIDSIV LSGMDSGSDQ
LSLKDIEIDP LEGKPNIDAS MDDFQKFSVG KKKVCFPSTR GKSGKFVLQR MGVMSQINKK
RSTRGKGRQL ALPSISSDRC PNRNMDTDLT SDKKMLLCSA RDKYILTQDI CVMCGSLGIE
SDSAMITCAQ CGQCYHPYCA GVKPSRGILQ KGWRCLDCTV CEGCGKKNDE ARLLLCDECD
ISYHIYCVNP PLETVPTGNW KCSFCTLCQK CGRNPTEKSE FGDSNMPECP PCASQSACNV
CKSAYANGEM IIQCEHCELW SHFLCDTVNA QLTIDHYDSN IYKCLKCRSA SKSLLSLMES
KHGDALGSGL QAHLSKTSLN ATLAGSGLDV KGLPDRNNMT LASEMSEVAP EALHWIDGVC
LSESGLGMIK SLSTEIKRKR KMRQTMGNGK DGQAEAAEEA QSEKYKDGMV WDGTENAIPE
GFTISTNDEG VHILRKKRQR NLQKLGIGGF SVRNRGLKKD SEEAAAADQL NALMIMDKKK
KIIRKKQKNK LIEAYPVYLQ EAFFGKPLLE CGEVVMAESD SSDEIDASMK MYFTRPEGKG
PEVETPPVTK SPAKTLKKVK AEKIVPENKT IFIEQMSMGI QQKPPMTPTA NVFDPSLTEM
TTVLTNRHPL DTLTSPNIAE LDGTNSVNMV APAEILEKPM RESPVVLVDN YMVPQQQLPQ
DQKFPSQMYL PGNMTVNPPQ MNPPQQLHFH QPSDLNLNAQ NANKPKMQGM MGQVIMQTDK
RPDEEVKVAE PATENLNAGT QKTAEKMRKD EDLGPMATIS AVLYANTEHP NLKELFPNWN
DRCKQILKRW RSLCNDKKAP FLQKAKDNRS ALRQRREQNK IPMPPKPQKQ EEMGRVWKQQ
PKLKEDQSNM FVTFNGNAYE MATYVSSPAQ PTTPHQIMTN VNENLVIKAT MQRTTVQATT
PNTMKMATVD NRLELNSVYG AEPIGDKKLR NLLQKNSTEP MLMGNNSDIF LQNDVLRMGM
MQNTPITQNN PMMSISGKSQ PSEGRTLEQE VKMGEPQESA ASAVELENVG FSDLLGGLGE
GDDDDLLKSL TSEMGDDFNI LEYADPELDV NVLNSLDFDD NEKCSA
//
