ID B6HS04_PENRW Unreviewed; 463 AA.
AC B6HS04;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Pc22g16940 protein {ECO:0000313|EMBL:CAP98982.1};
GN ORFNames=Pc22g16940 {ECO:0000313|EMBL:CAP98982.1}, PCH_Pc22g16940
GN {ECO:0000313|EMBL:CAP98982.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP98982.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP98982.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
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DR EMBL; AM920437; CAP98982.1; -; Genomic_DNA.
DR RefSeq; XP_002565607.1; XM_002565561.1.
DR AlphaFoldDB; B6HS04; -.
DR STRING; 500485.B6HS04; -.
DR GeneID; 8312179; -.
DR KEGG; pcs:Pc22g16940; -.
DR VEuPathDB; FungiDB:PCH_Pc22g16940; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002632_2_1_1; -.
DR OMA; IAKECCE; -.
DR OrthoDB; 68574at2759; -.
DR BioCyc; PCHR:PC22G16940-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 30..162
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 196..432
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 52573 MW; 249DB71AD6C7B12A CRC64;
MDQTETKERR DSGSHDITSP KKLVSQYHGS VEVVRAGTLA ALVENLTRHD KLDGSFNRTF
FATYKYFTSG AELLELLIDR FDCSPPTLTA IQTTEWTTQT KPLIRLRVIN VLKHWLEHFW
SEPKDIDTDR NLRILQSFAK RATDAIGTSA THQLLTIVQR RLAGLDCHRR SVSSISTAPK
PILPRKLDKL QFLKIDATEI ARQLTIMEAH MFGKVQRDEF LNKNWQKKGS PGTPERAPNI
RALIRYSNQL SNWVGALILA ESDVKKRTQV IGHLINVANT CRQLHNYSAV VSILAGLESA
PIYRLARTWA MVTERSCNTL RPLQVLTCSE HNYRAYRDTL QVAVAPCVPF LGLFLKDLTF
IEDGNPAMTP EGLINFHKYT MLASTIHEIQ RLKEAPYSLR PVPELQEYLV TQLQSAVDLH
DMWDKSCELE TRGRDLGNRP RDLYTPTGGM FASMVVACMV LDD
//
