ID B7QMI2_IXOSC Unreviewed; 227 AA.
AC B7QMI2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=maleylacetoacetate isomerase {ECO:0000256|ARBA:ARBA00013199};
DE EC=5.2.1.2 {ECO:0000256|ARBA:ARBA00013199};
DE Flags: Fragment;
GN Name=8043486 {ECO:0000313|EnsemblMetazoa:ISCW023198-PA};
GN ORFNames=IscW_ISCW023198 {ECO:0000313|EMBL:EEC20054.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC20054.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC20054.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW023198-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW023198-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate;
CC Xref=Rhea:RHEA:14817, ChEBI:CHEBI:17105, ChEBI:CHEBI:18034;
CC EC=5.2.1.2; Evidence={ECO:0000256|ARBA:ARBA00001622};
CC -!- COFACTOR:
CC Name=glutathione; Xref=ChEBI:CHEBI:57925;
CC Evidence={ECO:0000256|ARBA:ARBA00001955};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC {ECO:0000256|ARBA:ARBA00004671}.
CC -!- SIMILARITY: Belongs to the GST superfamily. Zeta family.
CC {ECO:0000256|ARBA:ARBA00010007}.
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DR EMBL; ABJB010199034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS971485; EEC20054.1; -; Genomic_DNA.
DR RefSeq; XP_002416387.1; XM_002416342.1.
DR AlphaFoldDB; B7QMI2; -.
DR STRING; 6945.B7QMI2; -.
DR PaxDb; 6945-B7QMI2; -.
DR EnsemblMetazoa; ISCW023198-RA; ISCW023198-PA; ISCW023198.
DR GeneID; 8043486; -.
DR KEGG; isc:IscW_ISCW023198; -.
DR VEuPathDB; VectorBase:ISCI023198; -.
DR VEuPathDB; VectorBase:ISCP_009925; -.
DR VEuPathDB; VectorBase:ISCW023198; -.
DR HOGENOM; CLU_011226_20_1_1; -.
DR InParanoid; B7QMI2; -.
DR OMA; WYRHWVR; -.
DR OrthoDB; 986565at2759; -.
DR UniPathway; UPA00139; UER00340.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR GO; GO:0016034; F:maleylacetoacetate isomerase activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IBA:GO_Central.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd03191; GST_C_Zeta; 1.
DR CDD; cd03042; GST_N_Zeta; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR005955; GST_Zeta.
DR InterPro; IPR034330; GST_Zeta_C.
DR InterPro; IPR034333; GST_Zeta_N.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR01262; maiA; 1.
DR PANTHER; PTHR42673; MALEYLACETOACETATE ISOMERASE; 1.
DR PANTHER; PTHR42673:SF4; MALEYLACETOACETATE ISOMERASE; 1.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF02798; GST_N; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW Isomerase {ECO:0000313|EMBL:EEC20054.1};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7QMI2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:EEC20054.1};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..227
FT /note="maleylacetoacetate isomerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010959915"
FT DOMAIN 10..93
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 98..218
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC20054.1"
SQ SEQUENCE 227 AA; 25805 MW; C33E68B752CFE24E CRC64;
QTLLFFFFFF QPILYSYFRS SCAYRVRIAL ALKNVEYEQK TVNLMKDGGE QKSAEFTERN
PMQQVPVLEV NGEPLFQSLA IIEYLEEKYP EPSLLPKDLV LRSKVRAIAE LIASGIQPLQ
NIGILFKLEQ SKRNEWAVEF ISKGFQALEA VLAKTAGKYC VGDSVTMADA CLVPQVYNAK
RFKVDLAPYP TIVRVNNTLE KLEAFKAAHP CCQPDTPEEL KDPSKHF
//
