ID C4R217_KOMPG Unreviewed; 1020 AA.
AC C4R217;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-4 specific {ECO:0000256|ARBA:ARBA00015839, ECO:0000256|PIRNR:PIRNR037104};
DE EC=2.1.1.354 {ECO:0000256|ARBA:ARBA00012182, ECO:0000256|PIRNR:PIRNR037104};
GN OrderedLocusNames=PAS_chr2-2_0494 {ECO:0000313|EMBL:CAY69541.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY69541.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY69541.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- FUNCTION: Catalytic component of the COMPASS (Set1C) complex that
CC specifically mono-, di- and trimethylates histone H3 to form
CC H3K4me1/2/3, which subsequently plays a role in telomere length
CC maintenance and transcription elongation regulation.
CC {ECO:0000256|PIRNR:PIRNR037104}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA-
CC COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354;
CC Evidence={ECO:0000256|ARBA:ARBA00000944,
CC ECO:0000256|PIRNR:PIRNR037104};
CC -!- SUBUNIT: Component of the COMPASS (Set1C) complex.
CC {ECO:0000256|PIRNR:PIRNR037104}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037104}.
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DR EMBL; FN392320; CAY69541.1; -; Genomic_DNA.
DR RefSeq; XP_002491821.1; XM_002491776.1.
DR AlphaFoldDB; C4R217; -.
DR STRING; 644223.C4R217; -.
DR EnsemblFungi; CAY69541; CAY69541; PAS_chr2-2_0494.
DR GeneID; 8199075; -.
DR KEGG; ppa:PAS_chr2-2_0494; -.
DR eggNOG; KOG1080; Eukaryota.
DR HOGENOM; CLU_004391_1_0_1; -.
DR InParanoid; C4R217; -.
DR OMA; ERLPCLC; -.
DR OrthoDB; 950362at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd12302; RRM_scSet1p_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR024657; COMPASS_Set1_N-SET.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR044570; Set1-like.
DR InterPro; IPR017111; Set1_fungi.
DR InterPro; IPR048669; SET1_RBD.
DR InterPro; IPR024636; SET_assoc.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45814; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR PANTHER; PTHR45814:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR Pfam; PF11764; N-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF21569; SET1_RBD; 1.
DR Pfam; PF11767; SET_assoc; 1.
DR PIRSF; PIRSF037104; Histone_H3-K4_mtfrase_Set1_fun; 1.
DR SMART; SM01291; N-SET; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS51572; SAM_MT43_1; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|PIRNR:PIRNR037104};
KW Chromosome {ECO:0000256|PIRNR:PIRNR037104};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037104}; Nucleus {ECO:0000256|PIRNR:PIRNR037104};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR037104};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037104}.
FT DOMAIN 878..995
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1004..1020
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 117656 MW; D9FB272123580A4A CRC64;
MSYNRSYHDG YGRERTSNMR PSYNEYSDWD DFSWEKEDPH SRRYGSRPSS YIYNNPRPNA
DRPNGSIRNH VNRTARAPRN STQGLKFQPI PEKYQNISYN VDMFPRQLHH VDEFRKFTNS
IVSTQRNFRI VYDPEVKKDK RKGNAILIKK QEESDPKVLI DPRKELSSYP HIQRSDGTKS
AKRMFRSLLP TKHTYDSASV GPPPTIEIII HGLSPSTAQT VLKNNYKRYG PIADCRAVVD
PVTAVPLGLF VLSFSGKIDE AHTSCLKALN AAKDGVRVNG GVPRTTLFSE SRLNEIKHKI
IKQNENKRQA EVSEQQRLEQ ERKLQDQRRL QYEKEQELKR QRGSLRIKKQ EEDQQRIISK
QLLNNTELSN IFHSAMKDES HNQTLYTRNG NNGRHHRLSK VVDDAIRKRP YLFISAKFIP
VRDVPAREIM NLLRNYPWKR VLTDAEGFYV VFDSIKEAEK CLENEDGRKF YQRRLYMDLV
IHPDFMEDKT ELGVEQSISD QSTSIISSEL ERYLIKDIKD KIIAPTILEM LRAENFSVEI
ESALKKKKDL EEKVSEPYTT ATTVSPVTDS FTSFKLPTLP SFRKSNISKK ESSSRKKQKL
GTRKRYHALP MTHVLNFDSE GETDEHDSGP ETPNGVLMSM GPNRLLSERK QSFISDSSTS
EDESEVERDS EITTPEKHLG EKSNEQELAL ETSDDKAELK NNWIMYDPKY RPTTFIRPVG
ELYDAKTIDI PRLKKLIEDD EDLKLAQKLF SDINPDHSIP CVAYWIWNNL RAFTESSNLP
NSLGPMYSNQ SGSFKSEGYT KIPDTEKSEY LPHRRKIHKP LNTVENDDEA ANPNPKLQSS
RVNRANNRRF AADINAQKQM LNSETDILDL NHLTKRKKPV SFARSAIHNW GLYALEPIAA
KEMIIEYVGE ILRQKVSEVR EKKYLKSGIG SSYLFRVDED TVIDATKKGG IARFINHCCQ
PSCTAKIIKV EGKKRIVIYA LKDIAANEEL TYDYKFERED NNEERIPCLC GVPGCKGYLN
//
