ID D6WV41_TRICA Unreviewed; 1258 AA.
AC D6WV41;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012418, ECO:0000256|RuleBase:RU003805};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418, ECO:0000256|RuleBase:RU003805};
GN Name=AUGUSTUS-3.0.2_06188 {ECO:0000313|EMBL:EFA08534.1};
GN ORFNames=TcasGA2_TC006188 {ECO:0000313|EMBL:EFA08534.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA08534.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA08534.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA08534.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA08534.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA08534.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU003805}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU003805};
CC -!- SIMILARITY: Belongs to the phage and mitochondrial RNA polymerase
CC family. {ECO:0000256|ARBA:ARBA00009493, ECO:0000256|RuleBase:RU003805}.
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DR EMBL; KQ971357; EFA08534.1; -; Genomic_DNA.
DR RefSeq; XP_967600.2; XM_962507.3.
DR AlphaFoldDB; D6WV41; -.
DR STRING; 7070.D6WV41; -.
DR EnsemblMetazoa; TC006188_001; TC006188_001; TC006188.
DR GeneID; 655952; -.
DR KEGG; tca:655952; -.
DR eggNOG; KOG1038; Eukaryota.
DR HOGENOM; CLU_003364_2_0_1; -.
DR InParanoid; D6WV41; -.
DR OMA; WWAKSDE; -.
DR OrthoDB; 143789at2759; -.
DR PhylomeDB; D6WV41; -.
DR Proteomes; UP000007266; Linkage group 8.
DR GO; GO:0034245; C:mitochondrial DNA-directed RNA polymerase complex; IBA:GO_Central.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IBA:GO_Central.
DR GO; GO:0001018; F:mitochondrial promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR GO; GO:0006390; P:mitochondrial transcription; IBA:GO_Central.
DR Gene3D; 1.10.287.280; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.10.1320.10; DNA-directed RNA polymerase, N-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR046950; DNA-dir_Rpol_C_phage-type.
DR InterPro; IPR002092; DNA-dir_Rpol_phage-type.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR037159; RNA_POL_N_sf.
DR InterPro; IPR029262; RPOL_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10102; DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR10102:SF0; DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00940; RNA_pol; 1.
DR Pfam; PF14700; RPOL_N; 1.
DR SMART; SM01311; RPOL_N; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS00900; RNA_POL_PHAGE_1; 1.
DR PROSITE; PS00489; RNA_POL_PHAGE_2; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU003805};
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU003805};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Transcription {ECO:0000256|RuleBase:RU003805};
KW Transferase {ECO:0000256|RuleBase:RU003805}.
FT DOMAIN 411..731
FT /note="DNA-directed RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01311"
SQ SEQUENCE 1258 AA; 143509 MW; CAA40D757934C698 CRC64;
MYRLFNTRIS SFRKLTNLSS GFNSENVNFK VRDGGGLLNT QLNNYCIACA RNQSTNTNPN
LAPKKIRKRS KSKKSYYDLL VVTETNAKQQ KTSIKKLTWN DLKLLASTNL NLSELHKLKD
LTKDNQHVQE HTYNNLAVID PIAAEETPNE KERVVTITDI PQPPEQPQPP VEELLDTIPK
IDFLQPEIID EPPEISEVSD PAPKINLSKK ARYEISVKTL GSYLEMCSTL QTPNRGLNAL
IFHNQRATRG KDLTFATMKS IKVYNAVLKG FAAKGETSRL EEVLAMVRKE NVKLNLQSYI
AILECYGRAN FHDHYLKQIR IYAKEAVTNG FTFDRMLNEG TFLNDERAVV LATMQKFDPS
YRPKYAEPIV QYDNELVNSL NHDSQLELPE EGRLIDETGL FTPGFMQSAV AKQLELEKTG
QIVVKSIENR GKVSDEVTKY REIMNQHIRD WEETAAKAFN RDLSALAAQK SPLNPEIYMR
SIPLKDFVTI LVNEAKQIAE GSETYSPTVN QLYRDLGSKV YARYKILRKQ KTGVLDKVQS
IHSRYCQSYA HQHEELGVLP ETVHHVNPRQ QWQWFEYSMK GTGATLTMDH RTWSPSTLQT
IGKFLYKIVM HDLKVDVNAM KANIKHKNNH PAFYTVFRTQ GRVLKEEVKP HPVLARLFRA
SMPETLTFPA NELPMFCPPV PWTCVDNGGY LIVPCEVVRL PPQATSQKQR LYQSEVQQLY
PPLDALNQLA AVAWKVNTDV LDVILEVFNN GGSAKLDVPE PPTALARPQA ITNDMDKAQK
FKLFRQKLQY RRKKAEMYSL WCDCLYRLSL ANHFRSDIFW LPHNMDFRGR VYPVPPHLNH
LGSDLARSML VFAESRPLGP DGLNWLKLHL INLTGLKKRD SITDRLAYAD TIMDDILDSA
DSPLTGRQWW AESEEPWQTL ACCIEIAKAT RSGNPETYRS HFPVHQDGSC NGLQHYAALG
RDSAGAYSVN LCPSEVPQDV YSAVVALVEQ QRLVDAANGV EVAKALHGFV KRKVIKQTIM
TTVYGVTKYG ARLQIARQLK DIDDFPKDLV WAASSYLTGR TFDSLRSMFT STREIQDWFT
DCARLISMSG QHVEWVTPMG LPIVQPYIRY KNLGTSLVYK PYHMDEFEKP NVMKQKNAFP
PNFIHSLDSS HMMLTSLFCE RAGITFVSVH DCYWTHPSTV DIMNKICREQ FVALHSLPIL
ENLSMFLTEK YSFRNDDLIG DGSISDLTKT KLNKVLRKLP KTGDFDITQV LKSVYFFS
//
