ID E1ZZY3_CAMFO Unreviewed; 624 AA.
AC E1ZZY3;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN ORFNames=EAG_11415 {ECO:0000313|EMBL:EFN73255.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN73255.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|RuleBase:RU000675};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR EMBL; GL435531; EFN73255.1; -; Genomic_DNA.
DR RefSeq; XP_011268594.1; XM_011270292.2.
DR AlphaFoldDB; E1ZZY3; -.
DR STRING; 104421.E1ZZY3; -.
DR GeneID; 105258784; -.
DR KEGG; cfo:105258784; -.
DR InParanoid; E1ZZY3; -.
DR OMA; RAHPDTW; -.
DR OrthoDB; 5489808at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF165; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000675};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000675};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..624
FT /note="Beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003156309"
FT DOMAIN 40..360
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 406..512
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 539..599
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 189
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 269
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 624 AA; 69855 MW; FB68843D4CF694C1 CRC64;
MWSLVFVTTL ALSSAVSETV NLPSNDTWQY SFGVDYENNQ FLLDGKPFRY VSGSFHYFRA
PRQYWRDRLR KMRAAGLNAV STYVEWSLHE PEPGQFNWAG DADLIEFLNI AQEEDLFVLL
RPGPYICAER DLGGLPYWLL REAPDIKLRT KDAAFMKYAT AYLNQVLEKV KPLLRGNGGP
IIMVQIENEY GSYNACDTEY TDMLKEIIVG KVGSKALLYT TDGASASLLR CGFVPGAYAT
IDFGTSVNVT NSFQSMRLYQ PRGPLVNSEF YPGWLTHWGE TFQRVKTEAV TKTLREMLAL
GASVNIYMFY GGTNFGFTSG ANGGVGAYSP QITSYDYDAP LTEAGDPTDK YFAIRDVIGQ
YLPLPNISLP TESPKGNYGP VLLEPIQKLF DSESSFVISW ASSDKPRTFE HLSVNQGFVL
YETDLPPPVF DPVILRATIK DRALVYVDGR LSGTLSRMDK IFTIPLENPY GRRLSLLIEN
QGRLNFGNEI HDFKGISNVT LSGTPLINWN MTGYALSDVS FLQDVMTIDI ESGTLNNGPV
FLRGRFTITG QPLDTFLDPT GWGKGVAFVN GHNLGRYWPL VGPQITLYVP APYLRTGENE
LILLELEYIS QTRKMKFQSV PNLG
//
