ID   E4N9I2_KITSK            Unreviewed;       485 AA.
AC   E4N9I2;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Putative aldehyde dehydrogenase {ECO:0000313|EMBL:BAJ27863.1};
DE            EC=1.2.1.- {ECO:0000313|EMBL:BAJ27863.1};
GN   OrderedLocusNames=KSE_20400 {ECO:0000313|EMBL:BAJ27863.1};
OS   Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304
OS   / NBRC 14216 / KM-6054) (Streptomyces setae).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Kitasatospora.
OX   NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ27863.1, ECO:0000313|Proteomes:UP000007076};
RN   [1] {ECO:0000313|EMBL:BAJ27863.1, ECO:0000313|Proteomes:UP000007076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC   KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX   PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA   Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA   Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA   Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T., Horinouchi S.,
RA   Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A., Nomoto F., Miura H.,
RA   Takahashi Y., Fujita N.;
RT   "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT   snapshot of the family Streptomycetaceae.";
RL   DNA Res. 17:393-406(2010).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AP010968; BAJ27863.1; -; Genomic_DNA.
DR   RefSeq; WP_014135181.1; NC_016109.1.
DR   AlphaFoldDB; E4N9I2; -.
DR   STRING; 452652.KSE_20400; -.
DR   KEGG; ksk:KSE_20400; -.
DR   PATRIC; fig|452652.3.peg.2049; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_11; -.
DR   Proteomes; UP000007076; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR42986; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   PANTHER; PTHR42986:SF1; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007076}.
FT   DOMAIN          24..474
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        253
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   485 AA;  51453 MW;  26254935DFC7C781 CRC64;
     MSLIAELAQQ YIDGQWRPGT GSWDIVDLDP YSGEKLASYT VATVEEVDLA YRAAERAQPA
     WAAASPYERR LVFERALRVV EEREAEILQV MTVELGGTLM KSGFELSLVK DMLREAGSLA
     LRAEGRILPS PVPGKENRLY RLPVGVVGVI SPFNAPVFLS LKAVAPALAL GNAVVLKPHQ
     DAPVAGGTLI ARIFEEAGLP AGLLNVVLTD IAEIGDAFIE HPVPKVIAFT GSDTVGRHVA
     AVAAAHLKRT VLELGGNSAL VVLDDADVDY AVDAAVASRF VHQGQICMAA NRILVDRALF
     AEFGEKFTAK VASLSVGDPG DPATQLGPLI NSAQAEHITA EVDRVLAAGA RALLHGATVG
     TLVRPTVLTD IPAEDPILRR EVFGPVALLI PFDGEEEAVR IANDTPFGLS GAVHTADVER
     GVRFAQRIDT GMIHVNDGTI ADEPLVPFGG EKGSGGGRLN GDASLDAFTT VKWISIQHGR
     SRFPF
//