ID E4NLK5_HALBP Unreviewed; 668 AA.
AC E4NLK5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN OrderedLocusNames=Hbor_16380 {ECO:0000313|EMBL:ADQ67208.1};
GN ORFNames=C499_05608 {ECO:0000313|EMBL:ELY29755.1};
OS Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 /
OS KCTC 4070 / PR3).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Halogeometricum.
OX NCBI_TaxID=469382 {ECO:0000313|EMBL:ADQ67208.1, ECO:0000313|Proteomes:UP000006663};
RN [1] {ECO:0000313|EMBL:ADQ67208.1, ECO:0000313|Proteomes:UP000006663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700274 / DSM 11551 / JCM 10706 / KCTC 4070 / PR3
RC {ECO:0000313|Proteomes:UP000006663}, and PR 3
RC {ECO:0000313|EMBL:ADQ67208.1};
RX PubMed=21304651; DOI=10.4056/sigs.23264;
RA Malfatti S., Tindall B.J., Schneider S., Fahnrich R., Lapidus A.,
RA Labuttii K., Copeland A., Glavina Del Rio T., Nolan M., Chen F., Lucas S.,
RA Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S., Anderson I.,
RA Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K.,
RA D'haeseleer P., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P., Chain P.;
RT "Complete genome sequence of Halogeometricum borinquense type strain
RT (PR3).";
RL Stand. Genomic Sci. 1:150-159(2009).
RN [2] {ECO:0000313|EMBL:ELY29755.1, ECO:0000313|Proteomes:UP000011585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11551 {ECO:0000313|EMBL:ELY29755.1,
RC ECO:0000313|Proteomes:UP000011585};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
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DR EMBL; CP001690; ADQ67208.1; -; Genomic_DNA.
DR EMBL; AOHT01000014; ELY29755.1; -; Genomic_DNA.
DR RefSeq; WP_006054443.1; NZ_AOHT01000014.1.
DR AlphaFoldDB; E4NLK5; -.
DR STRING; 469382.Hbor_16380; -.
DR GeneID; 9993457; -.
DR KEGG; hbo:Hbor_16380; -.
DR PATRIC; fig|469382.19.peg.1103; -.
DR eggNOG; arCOG01529; Archaea.
DR HOGENOM; CLU_000022_3_6_2; -.
DR OrthoDB; 371752at2157; -.
DR Proteomes; UP000006663; Chromosome.
DR Proteomes; UP000011585; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ADQ67208.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006663}.
FT DOMAIN 54..100
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 110..492
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 556..634
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 647..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 74808 MW; 304C5762CCF6692E CRC64;
MEVPDTDEVV HEPAREFVES TNVYEFMQEY GIEDYDELIR RTCTDVDGVA ESGVEWFWDE
LVEYLDIDFY EDYDAVRDDT DGPQFSEWYP GGSINVAHNV VDKHAAPDSE TRNNVALIWE
GEPGDERKIT YHDLHRESNR VANVLESYGI ETGDTVGLYM PMVPEVVSIL YGCLKVGAIA
VPIFSGFGVD ATATRIEDSE CSVLFTADGF YRRGGEVTLK DAADDAIAEA GHVEHTVVYD
RLGFEKREDR SIKWRTRDEW WHETVAEADS TYETKELDSS QESMLLYSSG TTGEPKGIVH
THAGVLMQCA KEIYFGFDHK PEDRFFWVSD IGWMMGPWTL IGNHAFGGTV FMYEGAPDHP
EPDRFWDMIE RHGLTTFGIS PTAIRALRKY GDGYVEQHDL STLRLLGSTG EPWDPESWMW
FYENVGGGDT PIINISGGTE ICGCFLMPMP SQPLKPCSLG GPGLGMNIDI VDSAGDSIAD
THERGFLVAR DSCPSMTKSL WSGDERYLKE YWSSFEDPPL WDHGDWAQKD EDGFWFLHGR
ADDALNVAGR KVGPAEIEGV LIEHDAVNQA AAVGVDDDTT GTAVVAYVVL EDDVEPTDEL
REELRELVGE EQGKPFRPRE LKFVSEFPKT QSGKIIRRAI AAVHQGEDTG DLSSIENPDA
LDEIRDAR
//
