ID E5RYV9_TRISP Unreviewed; 667 AA.
AC E5RYV9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Transmembrane protease serine 9 {ECO:0000313|EMBL:KRY32546.1};
GN Name=Tmprss9 {ECO:0000313|EMBL:KRY32546.1};
GN ORFNames=T01_13727 {ECO:0000313|EMBL:KRY32546.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY32546.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY32546.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY32546.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY32546.1}.
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DR EMBL; JYDH01000096; KRY32546.1; -; Genomic_DNA.
DR RefSeq; XP_003381667.1; XM_003381619.1.
DR AlphaFoldDB; E5RYV9; -.
DR SMR; E5RYV9; -.
DR STRING; 6334.E5RYV9; -.
DR EnsemblMetazoa; EFV62279; EFV62279; EFV62279.
DR GeneID; 10898475; -.
DR KEGG; tsp:Tsp_07356; -.
DR CTD; 10898475; -.
DR eggNOG; KOG3627; Eukaryota.
DR HOGENOM; CLU_506571_0_0_1; -.
DR InParanoid; E5RYV9; -.
DR OMA; GYFRSWI; -.
DR OrthoDB; 4629979at2759; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24264; TRYPSIN-RELATED; 1.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 2.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000313|EMBL:KRY32546.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|RuleBase:RU363034}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000313|EMBL:KRY32546.1}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..667
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010962152"
FT DOMAIN 39..282
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 340..582
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 588..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 71610 MW; D87397E57AB65A52 CRC64;
MKTVICILLL PLTILALPDD KCGLTAYPIR KTDPSGNKIA GGWYATPHSL PYQVKLLIEK
SGIHASCGGV IIQLKSGNGT DAVLTSARCL YQESLRKPVP VDKVDVISGA HDLENNFEES
QRKIPVKNFV LHPEYKGNSI NDIALLKLKE KILYTDKTRP ACLPDKDAEP SAGELCYASG
WGSPFSGAED SAVLKMAAIP VQTKEKCNLA GGIATRFCAG GSFGGHGICD GDSGGPLTCE
RNGKLVVFGI SSGHTGLCGQ YGKPGIFTKV SSFLDWIKKT DTELDTAVDM SKGKKAENIA
QPLDSDETTD AKQAGKVKEQ FPCGLSAFPM KKEQSPSNRV SGGWETRPNS LPYQVKLINQ
KQGKEFACGG TLIQFKPGNG TFWILTAAHC IYDNLRKKTL DPEKVQVLVG AHNVYRDSEE
NRKQIAVQNV IMQPGYNDRT IANDIALLQL QEPVFYTTVT RPACLPNPGE KPLPTTSCWV
SGWGAESSYG EPTAILKVAK VAIWNDADCK VDATSSICLG GKADRRGSCQ GDSGGPLLCE
HNKRMVVFGV SSSVVGHCGQ LNQPSIYTRV THYLDWLKET SEKAGDLKVT AASSTGGSSA
TSKPNKAKDD FTVRPSSPAK SVSSVPSQPA FPGSRFMTPL PTPGRPAASR FYTPPSSGLS
RSRFQTL
//
