ID   F7WAY9_SORMK            Unreviewed;       474 AA.
AC   F7WAY9;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|ARBA:ARBA00044146};
GN   ORFNames=SMAC_08869 {ECO:0000313|EMBL:CCC14304.1};
OS   Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX   NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC14304.1, ECO:0000313|Proteomes:UP000001881};
RN   [1] {ECO:0000313|EMBL:CCC14304.1, ECO:0000313|Proteomes:UP000001881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC   {ECO:0000313|Proteomes:UP000001881};
RC   TISSUE=Mycelium {ECO:0000313|EMBL:CCC14304.1};
RX   PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA   Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA   Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., Poeggeler S.,
RA   Read N., Seiler S., Smith K., Zickler D., Kueck U., Freitag M.;
RT   "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT   Sordaria macrospora, a model organism for fungal morphogenesis.";
RL   PLoS Genet. 6:E1000891-E1000891(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024149};
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCC14304.1}.
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DR   EMBL; CABT02000067; CCC14304.1; -; Genomic_DNA.
DR   RefSeq; XP_003344127.1; XM_003344079.1.
DR   AlphaFoldDB; F7WAY9; -.
DR   STRING; 771870.F7WAY9; -.
DR   GeneID; 10801406; -.
DR   KEGG; smp:SMAC_08869; -.
DR   VEuPathDB; FungiDB:SMAC_08869; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_0_1_1; -.
DR   InParanoid; F7WAY9; -.
DR   OMA; PREQGQY; -.
DR   OrthoDB; 216092at2759; -.
DR   Proteomes; UP000001881; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07091; ALDH_F1-2_Ald2-like; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001881}.
FT   DOMAIN          205..469
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        246
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   474 AA;  51884 MW;  33D3A49B87AD257A CRC64;
     MSSNVFVELK TPITGPFKQP TGLFINNEFV EGVEKKTFEV INPATEEVIC SVHEATEKDV
     DLAVTAARKA FDGVWRETTP QQRGIYLLKL ADLIEKNLDL LAAVESLDNG KSITMARGDV
     GAVVGTIRYY GGWADKVEGK TIDISPDTFH YTRQEPLGVC GQIIPWNFPL LMLAWKIGPA
     LATGNTIVMK TAEQTPLSAL VFAQVAGAAI SSHMDIDKVA FTGSTVVGRQ IMKAAAESNL
     KKVTLELGGK SPNIIFNDAD IEQAIDWVNF GIYFNHGQTC CAGSRVYVQE GIYDKFVEAF
     KKRASENKVG DPFHDETFQG PQVSQLQYDR IMGYIKAGQE EGATVEIGGE RHGDKGYFIQ
     PTIFTNVKPD MKIMREEIFG PVCAVAKFST EDEVIKLGND SNYGLAAAVH TKDLNTAIRV
     SNHLRAGTVW VNCYNALHHQ LPFGGYKESG IGRELGEAAL ANYTQCKSVA IKLN
//