ID G0RMS1_HYPJQ Unreviewed; 879 AA.
AC G0RMS1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EGR47529.1};
DE Flags: Fragment;
GN ORFNames=TRIREDRAFT_35240 {ECO:0000313|EMBL:EGR47529.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR47529.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR47529.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; GL985068; EGR47529.1; -; Genomic_DNA.
DR RefSeq; XP_006966494.1; XM_006966432.1.
DR AlphaFoldDB; G0RMS1; -.
DR STRING; 431241.G0RMS1; -.
DR EnsemblFungi; EGR47529; EGR47529; TRIREDRAFT_35240.
DR GeneID; 18484635; -.
DR KEGG; tre:TRIREDRAFT_35240; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_35240; -.
DR eggNOG; KOG1079; Eukaryota.
DR HOGENOM; CLU_004089_2_0_1; -.
DR OrthoDB; 902834at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR048360; Ezh2-like_CXC_fung.
DR InterPro; IPR040968; Ezh2_MCSS_fung.
DR InterPro; IPR040595; EZH2_N.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF21509; Ezh2-like__CXC_fung; 1.
DR Pfam; PF18600; Ezh2_MCSS_fung; 1.
DR Pfam; PF18601; EZH2_N; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 451..568
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 583..712
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 725..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..771
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EGR47529.1"
FT NON_TER 879
FT /evidence="ECO:0000313|EMBL:EGR47529.1"
SQ SEQUENCE 879 AA; 99425 MW; 5ED5D6C03E92647E CRC64;
TPKTQTVPVT EWTVRTLAKQ LTTFNQQVRK DHAQLVAHAI ESARCREWRT QHGLDLFREL
TTHPNPEIKG KQIKIKFKQH NKNKKEQKDV RYNVHCVKTN KPAVPSYRFH HVEIKKNVLM
PNTMLTFVPH LRDLEGSEEA KYNLWLKELE DIDLKSGFKP MNRDEKFVAI IQGERAATLS
LYLDMWLKEL NIPSCNKSTL IRYMASHASD DAITPQQKTD IIKSHGHGHA MTPEEHRAAE
LFTAAFQLAF KENQPQLKQI ELRKVLFLDE SVDSVMDNKP AAKEVSLVQQ DNEDEVVESN
LATYCILGCL ICFSHSCDHG EYDIKNWKRT FSLSSCAPLS DILRRKRIAA AGVNTIADVP
CRRRCYRLKI PPDPTSAVAK PWTEDERMLL RTLYITTDFS KTKMDPICLA TEFLNRNCDE
VYAEFQSLSI GIPGPDLTEP PRPRNISWYD RKRKMLIGDW QEHTITHEHQ RRELLEPCSH
DGPCAPKICS CVDAGVLCER FCGCTEANCA YKFTGCACHS LGKTCLPKQK DRPCICVQLN
RECDPQLCGS CGAFERADPA NAEDDILHSA GCQNCDLQRG RHKALLLGQS QLEGVGYGLF
TAEDIAQDEF IVEYVGELIT HDEGVRREAR RGDVFDETSN ISYVFTLLEN EGIWVDAAIY
GNLSRYINHA SEHDTRGCNI TPRILYVNGE FRIKFTALRD IKAGEELFFN YGENFPNLTK
KLLDNKSGEK AEGPRKVGRP KRAETGDRVA RKVPKIIEHK KAGRPKSKKK KMAAAATTVT
TTTTTTVQAA RKRHTMIDSE EEEYHPPGTD TASSAAAHAT TEDGELLGSK RLRKTTRSQR
AKEPETPAVK TPGSEEQQKP RGKRGGARPG SGRPRKHPR
//
