ID   H2QXA8_PANTR            Unreviewed;       517 AA.
AC   H2QXA8; A0A2J8QRI8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=Aldehyde dehydrogenase X, mitochondrial {ECO:0000256|ARBA:ARBA00040048};
DE            EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
DE   AltName: Full=Aldehyde dehydrogenase family 1 member B1 {ECO:0000256|ARBA:ARBA00041645};
GN   Name=ALDH1B1 {ECO:0000313|EMBL:JAA05233.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000035841.1, ECO:0000313|VGNC:VGNC:4609};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000035841.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000035841.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|EMBL:JAA05233.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA05233.1}, Skeletal muscle
RC   {ECO:0000313|EMBL:JAA35772.1}, Skin {ECO:0000313|EMBL:JAA24361.1}, and
RC   Smooth vascular {ECO:0000313|EMBL:JAA11560.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000035841.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024149};
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol:
CC       step 2/2. {ECO:0000256|ARBA:ARBA00037885}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AACZ04033376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01006105; JAA05233.1; -; mRNA.
DR   EMBL; GABF01010585; JAA11560.1; -; mRNA.
DR   EMBL; GABD01008739; JAA24361.1; -; mRNA.
DR   EMBL; GABE01008967; JAA35772.1; -; mRNA.
DR   RefSeq; XP_009454522.1; XM_009456247.2.
DR   STRING; 9598.ENSPTRP00000035841; -.
DR   PaxDb; 9598-ENSPTRP00000035841; -.
DR   Ensembl; ENSPTRT00000038769.2; ENSPTRP00000035841.1; ENSPTRG00000020956.2.
DR   GeneID; 464931; -.
DR   CTD; 219; -.
DR   VGNC; VGNC:4609; ALDH1B1.
DR   eggNOG; KOG2450; Eukaryota.
DR   GeneTree; ENSGT00940000162530; -.
DR   HOGENOM; CLU_005391_0_2_1; -.
DR   OMA; WVNRYGR; -.
DR   OrthoDB; 2291791at2759; -.
DR   TreeFam; TF300455; -.
DR   Proteomes; UP000002277; Chromosome 9.
DR   Bgee; ENSPTRG00000020956; Expressed in liver and 19 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   CDD; cd07141; ALDH_F1AB_F2_RALDH1; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF207; ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          45..508
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        285
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   517 AA;  57276 MW;  519E165467B1A798 CRC64;
     MLRFLAPRLL SLQGRTAHYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT
     TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNRLAD LVERDRVYLA
     SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPVGVCG
     QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG
     YGPTAGAAIA QHMDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM
     EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP
     QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP
     VQPLFKFKKI EEVIERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT
     PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS
//

ID   G2HHH5_PANTR            Unreviewed;       517 AA.
AC   G2HHH5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Aldehyde dehydrogenase X, mitochondrial {ECO:0000256|ARBA:ARBA00040048};
DE            EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
DE   AltName: Full=Aldehyde dehydrogenase family 1 member B1 {ECO:0000256|ARBA:ARBA00041645};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:BAK63183.1};
RN   [1] {ECO:0000313|EMBL:BAK63183.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAK63183.1};
RX   PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
RA   Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
RA   Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S., Hashimoto K.,
RA   Kim D.S., Park H.S.;
RT   "Major chimpanzee-specific structural changes in sperm development-
RT   associated genes.";
RL   Funct. Integr. Genomics 11:507-517(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024149};
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol:
CC       step 2/2. {ECO:0000256|ARBA:ARBA00037885}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AK306189; BAK63183.1; -; mRNA.
DR   RefSeq; NP_001266946.1; NM_001280017.1.
DR   AlphaFoldDB; G2HHH5; -.
DR   GeneID; 464931; -.
DR   KEGG; ptr:464931; -.
DR   CTD; 219; -.
DR   OrthoDB; 2291791at2759; -.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07141; ALDH_F1AB_F2_RALDH1; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF207; ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          45..508
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        285
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   517 AA;  57213 MW;  A28B44E7FA3C1FD6 CRC64;
     MLRFLAPRLL SLQGRTARYS SVAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT
     TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNRLAD LVERDRVYLA
     SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKCHGKT IPMDGQHFCF TRHEPVGVCG
     QIIPWNFPLV MQGWKLAPAL ATGSTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG
     YGPTAGAAIA QHMDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM
     EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP
     QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP
     VQPLFKFKKI EEVIERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT
     PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS
//