ID   H9GFI5_ANOCA            Unreviewed;       589 AA.
AC   H9GFI5;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=medium-chain acyl-CoA ligase {ECO:0000256|ARBA:ARBA00039009};
DE            EC=6.2.1.2 {ECO:0000256|ARBA:ARBA00039009};
GN   Name=ACSM3 {ECO:0000313|Ensembl:ENSACAP00000009526.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009526.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000009526.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009526.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000009526.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty
CC         acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00036212};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341;
CC         Evidence={ECO:0000256|ARBA:ARBA00036212};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   RefSeq; XP_008117824.1; XM_008119617.2.
DR   AlphaFoldDB; H9GFI5; -.
DR   STRING; 28377.ENSACAP00000009526; -.
DR   Ensembl; ENSACAT00000009723.4; ENSACAP00000009526.3; ENSACAG00000009637.4.
DR   GeneID; 100562048; -.
DR   KEGG; acs:100562048; -.
DR   eggNOG; KOG1175; Eukaryota.
DR   GeneTree; ENSGT00940000157930; -.
DR   HOGENOM; CLU_000022_59_10_1; -.
DR   InParanoid; H9GFI5; -.
DR   OMA; HAWSNLF; -.
DR   OrthoDB; 5474118at2759; -.
DR   TreeFam; TF354287; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000009637; Expressed in liver and 12 other cell types or tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0047760; F:butyrate-CoA ligase activity; IEA:Ensembl.
DR   GO; GO:0015645; F:fatty acid ligase activity; IBA:GO_Central.
DR   GO; GO:0004321; F:fatty-acyl-CoA synthase activity; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0018729; F:propionate CoA-transferase activity; IEA:Ensembl.
DR   GO; GO:0006637; P:acyl-CoA metabolic process; IBA:GO_Central.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR43605:SF3; ACYL-COENZYME A SYNTHETASE ACSM2B, MITOCHONDRIAL; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          79..429
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          495..575
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   589 AA;  66372 MW;  DD9018EAC0377C5A CRC64;
     MACITLTLTT WWKRSSLKTL RTFGIASIRR FSKYQLALAA QNFLDYESIQ QQYKAEVPEY
     FNFAKDVVDK WAKAEMEGKR PSNPALWWVS EQGDQVKWSF VELSHISKKA ARVLSEHCSL
     QKDDRVIVIL PRIPEWWLLN VACIRTGTIL IPGTTQLTSK DILHRLQASK ARCIVTDQVL
     APAVDTVASK CPSLEFKLIV SKEPREGWLN FNHLLNLSPG EHNCAVTKSH DPMAIYFTSG
     TTGAPKMTEH SHSSHGIGLG INGKYWLDLT PLDIMWNTSD TGWAKSAWSS VFAPWIQGAC
     VFIHSMPRFE PKPVLETLTK FPITTLCSPP TAYRMLIQHK LTSYKFHSLK HCLSAGEPMN
     PEVMEEWKME TGLDIYEGYG QTETVLVCGT FKGMKIKPGS MGKPSPAYDT QIINEEGNIL
     PSGKEGDIGI QIKPTRPFCL FTQYTDDPER TASTVRGDFY ITGDRGIKDE DGYFWFVGRA
     DDVINSAGYR IGPFEVESAL IEHPSVVESA VVSSPDPIRG EVVKAFVVLA PNYVSHDQEA
     LIKELQDHVK KVTAPYKYPR KVEFVPHLPK TISGKIRRNE LRKKEWGES
//