ID I1H4P3_BRADI Unreviewed; 279 AA.
AC I1H4P3;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
GN Name=100835449 {ECO:0000313|EnsemblPlants:KQK21323};
GN ORFNames=BRADI_1g60190v3 {ECO:0000313|EMBL:KQK21323.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQK21323.1};
RN [1] {ECO:0000313|EMBL:KQK21323.1, ECO:0000313|EnsemblPlants:KQK21323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK21323.1,
RC ECO:0000313|EnsemblPlants:KQK21323};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK21323.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK21323.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK21323}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK21323};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC Evidence={ECO:0000256|RuleBase:RU000544};
CC -!- SIMILARITY: Belongs to the thymidine kinase family.
CC {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
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DR EMBL; CM000880; KQK21323.1; -; Genomic_DNA.
DR EMBL; CM000880; KQK21324.1; -; Genomic_DNA.
DR RefSeq; XP_003557737.1; XM_003557689.3.
DR AlphaFoldDB; I1H4P3; -.
DR STRING; 15368.I1H4P3; -.
DR EnsemblPlants; KQK21323; KQK21323; BRADI_1g60190v3.
DR EnsemblPlants; KQK21324; KQK21324; BRADI_1g60190v3.
DR GeneID; 100835449; -.
DR Gramene; KQK21323; KQK21323; BRADI_1g60190v3.
DR Gramene; KQK21324; KQK21324; BRADI_1g60190v3.
DR KEGG; bdi:100835449; -.
DR eggNOG; KOG3125; Eukaryota.
DR HOGENOM; CLU_064400_1_1_1; -.
DR InParanoid; I1H4P3; -.
DR OMA; EAYEPRC; -.
DR OrthoDB; 674053at2759; -.
DR Proteomes; UP000008810; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004797; F:thymidine kinase activity; IBA:GO_Central.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046104; P:thymidine metabolic process; IBA:GO_Central.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001267; Thymidine_kinase.
DR InterPro; IPR020633; Thymidine_kinase_CS.
DR PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR Pfam; PF00265; TK; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|RuleBase:RU000544};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000544};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
SQ SEQUENCE 279 AA; 30416 MW; 6D935CC0B4C0D68F CRC64;
MRSVCAMTAL LSVCSSTSLR SSAFIPRAPF LSLPFRRDLS CSKLRLARSI STAAAAVKAR
AGGGRPLMEV RAAQSGEIHV IVGPMFAGKT TALIRRVQAE AATGRTVALI KSDKDNRYGL
DSAVTHDGTK MACWALPKLS SFQDKLGTEA YDKVDVIGID EAQFFDDLYD FCCKAADHDG
KIVVVAGLDG DYKRNKFGSV LDIIPLADSV TKLTARCELC GHRAFFTLRK TQETRTEFIG
GADVYMPVCR QHYLDGQIVI EATRIVMEVE RSTVTHALK
//
