ID J3K2T7_COCIM Unreviewed; 505 AA.
AC J3K2T7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:EAS28433.3};
GN ORFNames=CIMG_09637 {ECO:0000313|EMBL:EAS28433.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS28433.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986}.
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DR EMBL; GG704912; EAS28433.3; -; Genomic_DNA.
DR RefSeq; XP_001240016.2; XM_001240015.2.
DR AlphaFoldDB; J3K2T7; -.
DR STRING; 246410.J3K2T7; -.
DR GeneID; 4559061; -.
DR KEGG; cim:CIMG_09637; -.
DR VEuPathDB; FungiDB:CIMG_09637; -.
DR InParanoid; J3K2T7; -.
DR OMA; NAWAMLS; -.
DR OrthoDB; 216092at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07091; ALDH_F1-2_Ald2-like; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR11699:SF272; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 42..495
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 505 AA; 53362 MW; C68CECE1774B6DD6 CRC64;
MRTKSSVGIM AAQTVTLQGA EGRSIEIPTG LFINNEFVPS LTGTTLDTTN PANGDLLATI
AAASEEDINA AVQSAKDAFY TTWKATPPTT RQSLILKLAD LIERDVDEFA NLEALDGGIL
LSGSKGMHVP HSVETLRYFA GWADKIDGKS IAIPSGIAYT HREPLGVCAA IVPWNAPLIV
TMWKLAPCIA AGNTLVLKTS ELTPLYGIKL AALIKEAGFP AGVVNIVTGL GAVAGRALSE
HMDVRKIAFT GSTLTGRAIM KAAASSNLKK VTLELGGKGP TIIFDDADLQ NAVFWATLGI
TANNGQICVA GSRIYVQEGI YEKFIAAFSA ASTKAVAGDP LLSNTTKGPI VSADQHSKIM
GYIKKGQDEG ARLLHGGGQP APGYIENTAF VDVNEDMTIM REEIFGPVAA ISKFKTESEA
IQKANNTEYG LSSAIFTNNV SRADRVSRAL ESGQVTVNSW GMVHANVPFG GIKMSGFGKD
MGEESLDGWT GTKTIKYHTL PEVPN
//
