ID K0AA10_EXIAB Unreviewed; 339 AA.
AC K0AA10;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00013185, ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|ARBA:ARBA00013185, ECO:0000256|PIRNR:PIRNR005096};
GN Name=galM {ECO:0000313|EMBL:AFS69516.1};
GN OrderedLocusNames=Eab7_0355 {ECO:0000313|EMBL:AFS69516.1};
OS Exiguobacterium antarcticum (strain B7).
OC Bacteria; Bacillota; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX NCBI_TaxID=1087448 {ECO:0000313|EMBL:AFS69516.1, ECO:0000313|Proteomes:UP000006274};
RN [1] {ECO:0000313|EMBL:AFS69516.1, ECO:0000313|Proteomes:UP000006274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|Proteomes:UP000006274};
RX PubMed=23144424; DOI=10.1128/JB.01791-12;
RA Carneiro A.R., Ramos R.T., Dall'Agnol H., Pinto A.C., de Castro Soares S.,
RA Santos A.R., Guimaraes L.C., Almeida S.S., Barauna R.A., das Gracas D.A.,
RA Franco L.C., Ali A., Hassan S.S., Nunes C.I., Barbosa M.S., Fiaux K.K.,
RA Aburjaile F.F., Barbosa E.G., Bakhtiar S.M., Vilela D., Nobrega F.,
RA Dos Santos A.L., Carepo M.S., Azevedo V., Schneider M.P., Pellizari V.H.,
RA Silva A.;
RT "Genome sequence of Exiguobacterium antarcticum B7, isolated from a biofilm
RT in Ginger Lake, King George Island, Antarctica.";
RL J. Bacteriol. 194:6689-6690(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001614,
CC ECO:0000256|PIRNR:PIRNR005096};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; CP003063; AFS69516.1; -; Genomic_DNA.
DR RefSeq; WP_014969391.1; NC_018665.1.
DR AlphaFoldDB; K0AA10; -.
DR STRING; 1087448.Eab7_0355; -.
DR KEGG; ean:Eab7_0355; -.
DR PATRIC; fig|1087448.3.peg.359; -.
DR eggNOG; COG2017; Bacteria.
DR HOGENOM; CLU_031753_1_1_9; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000006274; Chromosome.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR018052; Ald1_epimerase_CS.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR PANTHER; PTHR10091:SF0; GALACTOSE MUTAROTASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT ACT_SITE 171
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 302
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 171..173
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 244
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 339 AA; 37337 MW; A341F91CBF242E5A CRC64;
MTEQTQLIQE TDLIRHTLTQ PGIEVEIWNY GGIINDIRVA DRDGRIESVV LGFDTLKEYQ
DHSPYFGAIV GRVAGRIGQA QMEVEGTVYP LATNDGTHHL HGGIKGFDQA LFEVVEATTD
RLHLRLFSPD GAEGYPGNVT LDAVYQLEGL ALTLTMHATT NQTTPLNLTN HTYWNLSGNL
RRDILDHHLT IPSETYLPVG ADLLPTGQLQ DVTGTPLDFR TGRLIRSGAE SGHPETVAAG
NGYDHPFLLS GQPIRLEDAS NGRYVEVTTN QPVVILYTGT QLETNYTIRG VGARPSLGLC
LETQVHPNAV NEPNFPDILV QPDQTYHWET TYRFGVNAG
//
