ID N6UDL6_DENPD Unreviewed; 508 AA.
AC N6UDL6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Catalase {ECO:0000256|RuleBase:RU000498};
DE EC=1.11.1.6 {ECO:0000256|RuleBase:RU000498};
DE Flags: Fragment;
GN Name=109538109 {ECO:0000313|EnsemblMetazoa:ENN76752};
GN ORFNames=D910_07741 {ECO:0000313|EMBL:ERL90392.1}, YQE_06817
GN {ECO:0000313|EMBL:ENN76752.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN76752.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN76752}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- FUNCTION: Occurs in almost all aerobically respiring organisms and
CC serves to protect cells from the toxic effects of hydrogen peroxide.
CC {ECO:0000256|RuleBase:RU004142}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000720,
CC ECO:0000256|RuleBase:RU000498};
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR038928-2};
CC -!- SIMILARITY: Belongs to the catalase family.
CC {ECO:0000256|ARBA:ARBA00005329, ECO:0000256|RuleBase:RU000498}.
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DR EMBL; APGK01039325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740969; ENN76752.1; -; Genomic_DNA.
DR EMBL; KB632230; ERL90392.1; -; Genomic_DNA.
DR RefSeq; XP_019760743.1; XM_019905184.1.
DR RefSeq; XP_019760745.1; XM_019905186.1.
DR AlphaFoldDB; N6UDL6; -.
DR STRING; 77166.N6UDL6; -.
DR EnsemblMetazoa; ENN76752; ENN76752; YQE_06817.
DR GeneID; 109538109; -.
DR KEGG; dpa:109538109; -.
DR HOGENOM; CLU_010645_2_0_1; -.
DR OMA; KFRWNVF; -.
DR OrthoDB; 3198922at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd08156; catalase_clade_3; 1.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR InterPro; IPR018028; Catalase.
DR InterPro; IPR040333; Catalase_3.
DR InterPro; IPR024708; Catalase_AS.
DR InterPro; IPR024711; Catalase_clade1/3.
DR InterPro; IPR011614; Catalase_core.
DR InterPro; IPR002226; Catalase_haem_BS.
DR InterPro; IPR010582; Catalase_immune_responsive.
DR InterPro; IPR020835; Catalase_sf.
DR PANTHER; PTHR11465; CATALASE; 1.
DR PANTHER; PTHR11465:SF9; CATALASE; 1.
DR Pfam; PF00199; Catalase; 1.
DR Pfam; PF06628; Catalase-rel; 1.
DR PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR PRINTS; PR00067; CATALASE.
DR SMART; SM01060; Catalase; 1.
DR SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
DR PROSITE; PS00437; CATALASE_1; 1.
DR PROSITE; PS00438; CATALASE_2; 1.
DR PROSITE; PS51402; CATALASE_3; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR038928-2};
KW Hydrogen peroxide {ECO:0000256|ARBA:ARBA00023324,
KW ECO:0000256|RuleBase:RU000498};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR038928-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR038928-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000498};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000256|RuleBase:RU000498};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 29..411
FT /note="Catalase core"
FT /evidence="ECO:0000259|SMART:SM01060"
FT ACT_SITE 76
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
FT ACT_SITE 149
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
FT BINDING 359
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN76752.1"
SQ SEQUENCE 508 AA; 57554 MW; 29DC436301C85ECC CRC64;
MASEDKASRQ ILDWKPKERA SCAESIYART AFGAPIVVKD ASETVGPKGP ILLQDAHFIE
DMAHFNRERI PERVVHAKGA GAFGYFKVTH DITEYCAAKV FEGIGKTTPI AVRFSTVGGE
AGSADTARDP RGFAVKFYTE DGNWDLVGNN TPVFFIKDPI LFSSFIHTQK RNPQTHLKDP
NMMWDFHTLR PESIHQWMFL FGDRGTPDGY RHMNGYGSHT FKLVNRDGKY HYCKFHYKTD
QGVKNLPVEK ADELAGSDPD YAIRDLYNAI ANKNYPSYSM YIQIMTPEQA QTSKFNPFDL
TKIWPHSDYP LIPVGKLVLD RNPENYFAEV EQIAFNPAHM VPGILPSPDR MLQGRLFTYG
DTHRYRLGPN YLQLPVNCPY KVKNYQRDGN MAISNQGNAP NYHPNSFSGP KVDPNVKVLY
PPYTITGDVN RYDEPMKDED FEQPAALWLR VLDEDAKTRL VNNLAGSLKS TADFIQERAV
KLYSRVHPTL GSRLEKALNL AARAKANL
//
