ID O18014_CAEEL Unreviewed; 376 AA.
AC O18014;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 142.
DE SubName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000313|EMBL:CAB07651.1};
GN Name=npr-25 {ECO:0000313|EMBL:CAB07651.1,
GN ECO:0000313|WormBase:T02E9.1};
GN ORFNames=CELE_T02E9.1 {ECO:0000313|EMBL:CAB07651.1}, T02E9.1
GN {ECO:0000313|WormBase:T02E9.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB07651.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB07651.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB07651.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; BX284605; CAB07651.1; -; Genomic_DNA.
DR PIR; T24368; T24368.
DR RefSeq; NP_505883.1; NM_073482.1.
DR AlphaFoldDB; O18014; -.
DR SMR; O18014; -.
DR STRING; 6239.T02E9.1.1; -.
DR PaxDb; 6239-T02E9-1; -.
DR EnsemblMetazoa; T02E9.1.1; T02E9.1.1; WBGene00011381.
DR GeneID; 179570; -.
DR KEGG; cel:CELE_T02E9.1; -.
DR UCSC; T02E9.1; c. elegans.
DR AGR; WB:WBGene00011381; -.
DR WormBase; T02E9.1; CE13062; WBGene00011381; npr-25.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00390000010256; -.
DR HOGENOM; CLU_736164_0_0_1; -.
DR InParanoid; O18014; -.
DR OMA; AICHPEN; -.
DR OrthoDB; 5393360at2759; -.
DR PhylomeDB; O18014; -.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-418555; G alpha (s) signalling events.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011381; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24229:SF95; G-PROTEIN COUPLED RECEPTOR C06G4.5-RELATED; 1.
DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..307
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 376 AA; 43141 MW; 1DBB2C4C3D3908D3 CRC64;
MNITNSSIGY PPPPLVGASF AKTAIPYSIC FVFGTLGNTA VLSYVFFITR SLKSSVTALG
NTFIYIVALC AVDLLVTVSI PFSLSYMILN NWVFGELVCK IHFMLELSNK MCSTFILTAL
AFDRYMAICH PEIKRIHEMR HTIYITTILA TLSLFLISPV VLSARVTSFK SGQYFVSAKN
ERHEVIRQMC IDGMALEWKV WVSAFLIFFA FLLPCTLLTY FYAKIVLRLR RQRRTMLQSR
IPLRRITIYT MAATFFYLSC HIPFWLPQIY NIFSTVLGHK MNPKVMTFTY YSHLLPFISA
AFNWIFYARL NSQFKKGLVL VTERMIRKRT KSMHEKGYSE AAVELTSKFD DVPLMCPHCE
AQLSIRSSSN GKKNSR
//
