ID Q12AS3_POLSJ Unreviewed; 496 AA.
AC Q12AS3;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Betaine-aldehyde dehydrogenase {ECO:0000313|EMBL:ABE44369.1};
DE EC=1.2.1.8 {ECO:0000313|EMBL:ABE44369.1};
GN OrderedLocusNames=Bpro_2450 {ECO:0000313|EMBL:ABE44369.1};
OS Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Polaromonas.
OX NCBI_TaxID=296591 {ECO:0000313|EMBL:ABE44369.1, ECO:0000313|Proteomes:UP000001983};
RN [1] {ECO:0000313|Proteomes:UP000001983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS666 / ATCC BAA-500 {ECO:0000313|Proteomes:UP000001983};
RX PubMed=18723656; DOI=10.1128/AEM.00197-08;
RA Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA Stothard P., Coleman N.V.;
RT "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT relevance to biotechnology.";
RL Appl. Environ. Microbiol. 74:6405-6416(2008).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CP000316; ABE44369.1; -; Genomic_DNA.
DR AlphaFoldDB; Q12AS3; -.
DR STRING; 296591.Bpro_2450; -.
DR KEGG; pol:Bpro_2450; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_2_4; -.
DR Proteomes; UP000001983; Chromosome.
DR GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd07138; ALDH_CddD_SSP0762; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR42804; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42804:SF1; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000001983}.
FT DOMAIN 34..488
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 496 AA; 52217 MW; C9401116320B1FA5 CRC64;
MPLPGLFPAI PQPFKADTTM PTTAYPAHYI NGQWVTARSS ETLPVYDSST EALMATVPSG
TAAEAEAAVL AARAAFDSWS TLPVETRAAY LDKVAAGVKA RTEDLALAIA REVGMPLKMA
RAVQVGGPIW HWGNFAKVAR SFEWEKKVGN SLVVREAVGV VGCITPWNFP LSQITLKIAP
AMAAGCTVVL KPSEIAPVNA MILAEIIHKA GLPPGVFNLI NGMGPVVGEV LATHSEIDMV
SFTGSTRAGK RVSELASQTV KRVALELGGK SASVILDDAN LEAAVKGTVS ACMLNSGQTC
SAHTRMLVPV HRYDEVKALA QAAIARFNIG PSLDETSKLG PLVSAAQRDR VLGFIRTGIE
EGAEVIAGGA AAPALDKGYF VQPTILGIKA TDTLAQEEIF GPVLVVIPYK DEDEAVAIVN
STIYGLGGAV WSGSDEHAMK VARRIRTGQV DINGGPFNGS APFGGYKQSG NGRENGVYGF
EEFLEFKALQ FKPSAS
//
