ID Q1L0R1_AEDAE Unreviewed; 358 AA.
AC Q1L0R1;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=p38b MAP kinase {ECO:0000313|EMBL:ABB82553.1};
GN Name=5570571 {ECO:0000313|EnsemblMetazoa:AAEL008379-PB};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:ABB82553.1};
RN [1] {ECO:0000313|EMBL:ABB82553.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UGAL {ECO:0000313|EMBL:ABB82553.1};
RA Wu R.C.C., Cho W.-L.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABB82553.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UGAL {ECO:0000313|EMBL:ABB82553.1};
RX PubMed=17466055; DOI=10.1111/j.1365-2583.2007.00734.x;
RA Wu R.C., Shaio M.F., Cho W.L.;
RT "A p38 MAP kinase regulates the expression of the Aedes aegypti defensin
RT gene in mosquito cells.";
RL Insect Mol. Biol. 16:389-399(2007).
RN [3] {ECO:0000313|EnsemblMetazoa:AAEL008379-PB, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL008379-PB,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblMetazoa:AAEL008379-PD}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL008379-PB};
RG EnsemblMetazoa;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; DQ270546; ABB82553.1; -; mRNA.
DR RefSeq; XP_001653240.1; XM_001653190.1.
DR EnsemblMetazoa; AAEL008379-RB; AAEL008379-PB; AAEL008379.
DR EnsemblMetazoa; AAEL008379-RD; AAEL008379-PD; AAEL008379.
DR EnsemblMetazoa; AAEL008379-RE; AAEL008379-PE; AAEL008379.
DR GeneID; 5570571; -.
DR VEuPathDB; VectorBase:AAEL008379; -.
DR HOGENOM; CLU_000288_181_1_1; -.
DR OrthoDB; 158564at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004707; F:MAP kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0033554; P:cellular response to stress; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009605; P:response to external stimulus; IEA:UniProt.
DR CDD; cd07851; STKc_p38; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR003527; MAP_kinase_CS.
DR InterPro; IPR008352; MAPK_p38-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR24055; MITOGEN-ACTIVATED PROTEIN KINASE; 1.
DR PANTHER; PTHR24055:SF158; MITOGEN-ACTIVATED PROTEIN KINASE P38A-RELATED; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR01773; P38MAPKINASE.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS01351; MAPK; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:ABB82553.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Transferase {ECO:0000313|EMBL:ABB82553.1}.
FT DOMAIN 20..305
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 358 AA; 41138 MW; 63C213B2492AA1F5 CRC64;
MPQFYKVEIN KTEWEVPQKY QMLTPVGSGA YGQVCSATDT QHNVKVAIKK LARPFQSAVH
AKRTYRELRM LKHMNHENII GLLDVFHPGG NTLDSFQQVY LVTHLMGADL NNIIRTQRLS
DDHVQFLVYQ ILRGLKYIHS AGIIHRDLKP SNIAVNEDCE LKILDFGLAR PTENEMTGYV
ATRWYRAPEI MLNWMHYNQT VDIWSVGCIM AELLTGRTLF PGTDHIHQLN LIMEILGTPN
EEFMAKISSE SARHYIRSLP KTEKRNFSDV FRGANPLAID LLEKMLELDA DKRVTAEQAL
AHPYLEKYAD PTDEPTSSLY DQSFEDMDLP VEKWKELVFQ EVLNFVPQQH AHIGSDGQ
//
