ID Q29FZ2_DROPS Unreviewed; 539 AA.
AC Q29FZ2; A0A6I8UEY5;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Cytochrome P450 18a1 {ECO:0000313|RefSeq:XP_001354384.1};
GN Name=LOC4814417 {ECO:0000313|RefSeq:XP_001354384.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001354384.1};
RN [1] {ECO:0000313|RefSeq:XP_001354384.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001354384.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001354384.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR RefSeq; XP_001354384.1; XM_001354348.4.
DR AlphaFoldDB; Q29FZ2; -.
DR SMR; Q29FZ2; -.
DR STRING; 46245.Q29FZ2; -.
DR EnsemblMetazoa; FBtr0273827; FBpp0272265; FBgn0079877.
DR GeneID; 4814417; -.
DR KEGG; dpo:4814417; -.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_22_0_1; -.
DR InParanoid; Q29FZ2; -.
DR OMA; ICGITMS; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0079877; Expressed in female reproductive system and 1 other cell type or tissue.
DR ExpressionAtlas; Q29FZ2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0008395; F:steroid hydroxylase activity; IEA:EnsemblMetazoa.
DR GO; GO:0007304; P:chorion-containing eggshell formation; IEA:EnsemblMetazoa.
DR GO; GO:0046344; P:ecdysteroid catabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0035210; P:prepupal development; IEA:EnsemblMetazoa.
DR GO; GO:0035074; P:pupation; IEA:EnsemblMetazoa.
DR CDD; cd20652; CYP306A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF376; CYTOCHROME P450 18A1; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819}.
SQ SEQUENCE 539 AA; 62172 MW; 15CA583011BF6D39 CRC64;
MLADSYLIKF LLRQLQVQQQ DAGAQHLLMV FLGFLALVSL LQWMLRHYRE LRKLPPGPWG
LPVIGYLLFM GNEKHTRFME LAKQYGSLFS TRLGSQLTVV MSDYKMIREC FRREEFTGRP
DTPFMQTLNG YGIINSTGKL WKDQRRFLHD KLRQFGMTYM GNGKQQMQKR IMTEVHEFIG
HLHASDGQPI DLSPVISVAV SNVICSLMMS TRFSIDDPKF RRFNFLIEEG MRLFGEIHTV
DYIPTMQCFP SISTAKNKIA QNRAEMQRFY QDVIDDHKRS FDPHNVRDLV DYYLCEIEKA
KAEGTDAELF DGKNHEEQLV QVIIDLFSAG METIKTTLLW INVFMLRNPK EMRRVQDELD
QVVGRHRLPT IEDLQYLPVT ESTILESMRR SSIVPLATTH SPTRDVELNG YTIPAGSHVI
PLINSVHMDP NLWEKPEEFR PSRFIDTEGK VRKPEYFIPF GVGRRMCLGD VLAKMELFLF
FASFMHCFDI ALPEGQPLPS LKGNVGATIT PEAFKVCLKR RPLAPTATDP HHMRNVGSN
//
