ID Q3TAQ9_MOUSE Unreviewed; 899 AA.
AC Q3TAQ9;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 142.
DE SubName: Full=WD repeat domain 36 {ECO:0000313|Ensembl:ENSMUSP00000052465.10};
GN Name=Wdr36 {ECO:0000313|Ensembl:ENSMUSP00000052465.10,
GN ECO:0000313|MGI:MGI:1917819};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE42609.1};
RN [1] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE42609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE42609.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42609.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [9] {ECO:0000313|Ensembl:ENSMUSP00000052465.10, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000052465.10,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [10] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [11] {ECO:0000313|Ensembl:ENSMUSP00000052465.10}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000052465.10};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AK171683; BAE42609.1; -; mRNA.
DR RefSeq; NP_001103485.1; NM_001110015.1.
DR STRING; 10090.ENSMUSP00000052465; -.
DR PaxDb; 10090-ENSMUSP00000052465; -.
DR ProteomicsDB; 328764; -.
DR Antibodypedia; 25310; 55 antibodies from 18 providers.
DR DNASU; 225348; -.
DR Ensembl; ENSMUST00000053663.11; ENSMUSP00000052465.10; ENSMUSG00000038299.17.
DR GeneID; 225348; -.
DR KEGG; mmu:225348; -.
DR UCSC; uc008ejn.2; mouse.
DR AGR; MGI:1917819; -.
DR CTD; 134430; -.
DR MGI; MGI:1917819; Wdr36.
DR VEuPathDB; HostDB:ENSMUSG00000038299; -.
DR eggNOG; KOG1539; Eukaryota.
DR GeneTree; ENSGT00940000153662; -.
DR OMA; WESVVTG; -.
DR OrthoDB; 5477616at2759; -.
DR TreeFam; TF300606; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 225348; 24 hits in 75 CRISPR screens.
DR ChiTaRS; Wdr36; mouse.
DR Proteomes; UP000000589; Chromosome 18.
DR Bgee; ENSMUSG00000038299; Expressed in cleaving embryo and 259 other cell types or tissues.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; ISO:MGI.
DR GO; GO:0030516; P:regulation of axon extension; IMP:MGI.
DR GO; GO:0001895; P:retina homeostasis; IMP:MGI.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:MGI.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007319; SSU_processome_Utp21.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22840; WD REPEAT-CONTAINING PROTEIN 36; 1.
DR PANTHER; PTHR22840:SF12; WD REPEAT-CONTAINING PROTEIN 36; 1.
DR Pfam; PF04192; Utp21; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q3TAQ9,
KW ECO:0007829|MaxQB:Q3TAQ9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 276..307
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 483..524
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 566..602
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 693..895
FT /note="Small-subunit processome Utp21"
FT /evidence="ECO:0000259|Pfam:PF04192"
SQ SEQUENCE 899 AA; 99721 MW; 3531A123F33113E8 CRC64;
MAEMESAVEG RTASVLFAGF RALGLFSNEV PHVVRYSALK RRFYVTTCVG KSFHTYDVQK
LSLVAVSNSV PQDICCMAAD GRLVFAAYGN VFSAFARNKE IVHTFKGHKA EIHLLQPFGD
HVISVDTDSV LIIWHIYSEE EYLQLTFDKS VFKISTILHP STYLNKVLLG SEQGSLQLWN
IKSNKLLYTF PGWKVGVTAL QQAPAVDVVA IGLVSGQVVI HNIKYDETLM KFHQDWGPIT
SISFRTDGHP IMAAGSPCGH IGLWDLEDKK LINQMRNAHS TAISGLTFLH REPLLVTNGA
DNALRIWIFD GPAGEGRLLR FRMGHSASLT KIRYYGQNGQ QILSASQDGT LQSFSTVHEK
FNKSLGHGLV NKKIVKRKGL QNTMSVRLPP ITQFAAEEAR QSDWDGIIAC HQGKRSCSTW
NYQRSTIGAY FLKPRGVKTN SNLTATAVDI TSCGNFAIIG LSSGAVDVYN MQSGIHRGNF
GDDKAHTGSV RGVAVDGLNQ LVVTAGSERL LKFWNFKSKV LIHSLGLDSS PNMMLLHRDS
GILGLAMDDF SIAVLDIETR KIVREFSGHH GQINDMTFSP DGRWLISAAM DCSVRTWDLP
SGCLIDCFLL DSAPLNVTMS PTGDFLATSH VDHLGIYLWS NISLYSVVSL RPLPPDYVPS
IVMLPGTCQT QGMEDLEEKT EPSDEMIEYE SPEQLSEQLV TLSLLPESRW KNLLNLDVIK
KKNKPKEPPK VPQSAPFFIP TVPGLVPRFA VPEPSSDPQQ SKVVNLGILA QKSNFYLKLE
EGLLNNQYEA ALNLLKELGP SGIETELRNL SPDDGGSVEV MRSFLSMIGM MLDRKRDFEL
AQAYLALFLK LHLRTLPSEP ALLEELVKLS SQVEKDWTHL QSLFNQSMCV LNYIKSAFL
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