ID Q4ZV34_PSEU2 Unreviewed; 4336 AA.
AC Q4ZV34;
DT 07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Non-ribosomal peptide synthase:Amino acid adenylation {ECO:0000313|EMBL:AAY36988.1};
GN OrderedLocusNames=Psyr_1945 {ECO:0000313|EMBL:AAY36988.1};
OS Pseudomonas syringae pv. syringae (strain B728a).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX NCBI_TaxID=205918 {ECO:0000313|EMBL:AAY36988.1, ECO:0000313|Proteomes:UP000000426};
RN [1] {ECO:0000313|EMBL:AAY36988.1, ECO:0000313|Proteomes:UP000000426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B728a {ECO:0000313|EMBL:AAY36988.1,
RC ECO:0000313|Proteomes:UP000000426};
RX PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA Kyrpides N.C., Ivanova N., Lindow S.E.;
RT "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT syringae B728a and pv. tomato DC3000.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP000075; AAY36988.1; -; Genomic_DNA.
DR RefSeq; WP_011267337.1; NC_007005.1.
DR RefSeq; YP_235026.1; NC_007005.1.
DR STRING; 205918.Psyr_1945; -.
DR KEGG; psb:Psyr_1945; -.
DR PATRIC; fig|205918.7.peg.1986; -.
DR eggNOG; COG0318; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_11_0_6; -.
DR OrthoDB; 9757559at2; -.
DR Proteomes; UP000000426; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17649; A_NRPS_PvdJ-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 581..656
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1637..1712
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2708..2782
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4239..4314
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4336 AA; 480465 MW; CAAF64BBB5629187 CRC64;
MDAFELPDTL AQALQRRALH TPDRLALRFL TDENDQGLVL TYRDLDLRAR TIAAALQRQA
VPGDRAILLF HSGPDYVAAF FGCLYAGVIA VPAYPPESNR RHHQERLLSI IADAEPRLLL
TGADLQPALL QMDELAAADA PPLLCVDTLP AAPAQEWQGP QLQADDIAFL QYTSGSTALP
KGVQVTHGNL VANESLIRHG FGIDANPDDV IVSWLPLYHD MGLIGGLLQP IFSGVPCILM
APAYFLARPL RWLEAISEYG GTISGGPDFA YQLCSARVSD SALERLDLSR WRVAYSGSEP
IREDSLRAFA DKFASCGFTP DSFMASYGLA EATLYVAGGK RGKGIPSLRL NAQALARNVV
EPGDGQPVMS CGTGQPGHGV LIADPVSLQV LGENQVGEVW ASGPSIAHGY WRNPEATARA
FVQHAGQTWL RTGDLGFQRH GELYITGRLK DMLIVRGHNL YPQDIEKLIE SEVDVVRKGR
VAAFAVTQDG SEGIGIAAEI SRSVQKILTP DALIKIIRQT VAEAFQEAPS VVVLLNPGAL
PKTSSGKLQR SACRTRLADG SLDSYAVFPA SDSTLAGCAP SSGSDLQAQI ATVWCEQLQC
EQVSADDHFF LLGGNSIIAT QVVARLRETL GIDLNLRLLF EAPTLAAFAA QVETLQTAAS
QGDSQTQSAI ARLPGNEHLP QSMAQNRLWF LWQLDPHSSA YNVPGGLHLR GELDSTALRS
SFQRLIERHE SLRTRFYEQD GVALQRIDAP SEFHLDTLDI SDLPGAERQA RAVAIREQQA
RLPFDLQHGP LLRVTLLRLD EEEHQLLVTL HHIIADGWSL NVLIDEFSRL YASAVQGQTL
ELAPLPLRYA DYGQWQREWL ANGEAERQLT YWQQQLGGEQ PVLTLNTDHP RSARQQHSAS
RYSLRLSAEL SAAVRNTAQA WQSTSFMFLL AGFQTLLHRY SGQADIRVGV PGANRPRHET
QGLIGFFINT LVLRAQLDPR LPFSTLLAQT RQAALEAQAH QDVPFEQLVE AFPRAREHGL
FQVMFNHQQR DLGALRRLPG LLAEELPWHS REAKFDLQLH SEEDRNGRLT LCFDYADELF
EHHTIVAMAQ HYVRLLTQVS QQAQLALGDV QLLSAEEQEQ QAQWSAAPCA PATLWLPELL
NHQARQTPER IALVWEGGSL DFASLHTQAN RLAHYLRDKG VGPDIKVAIA AERSPQLLIG
LLAILKAGGA YVPLDPDYPM DRLAYMLQDS GVELLLTQSH LLGDLPSAEG VCTVAMDTLH
LDNWPVSAPR LNLHGDNLAY VIYTSGSTGQ PKGVGNTHAA LAERLQWMQD TYALDESDVL
MQKAPISFDV SVWECFWPLI TGCRLLLAGP GEHRDPQRIA QLINAYSVTT LHFVPPLLQL
FIDEPLAQQC NSLRRLFSGG EALPGELRNR VLEQLPGVQL HNRYGPTETA INVTHWQCRI
SDGLRSPIGR PLGNVLCRVL DSELNPLPRV VAGELCIGGI GLARGYLRRP GLTAERFVAD
PLGQAGERLY RTGDLVRWAA DGALEYLGRL DQQVKLRGFR VEPQEIEARL LAQPGVGQAA
VLLRETVAGP QLIGYYTAEA GQNVEAERIK SALALELPDY MVPAQLVRLD SMPLSPSGKL
DRRALPEPQW QTREHVEPQT DLQKQIAAVW RQVLGVPRVG LRDDFFELGG HSLLATQIIS
RVRQACDIDL PLRTLFEASE LGAFAAQVEA IQQSGARSSL QPIARVDRSQ PVPLSYSQQR
MWFLWQMEPD SPAYNVGGMA RLKGVLNIEC FEAALQALIL RHETLRTTFP SINGVACQRV
SEQSDLRVQW QDYSALPVEA RQQRIQALAD SEAHQPFDLE TGPLLRAFLV KASDLEHYFV
LTLHHIVTEG WAMDIFAREL GQLYEAFLEG RPSPLEPLAV HYLDYSVWQR QWMEAGERQR
QLDYWTAQLG NEHPLLELPA DRPRPPVQSH QGELYRFDLN ADLAAKVRAF NARNGLTLFM
TMTATLAVLL YRYSGQNDLR IGAPVANRIR PESEGLIGAF LNTQVLRVQL DGQMSVAQLF
EQVRHTVIEG QSHQDLPFDH LVEALQPPRS AAYNPLFQVM CNVQRWEFQQ SRELAGMTVE
YLVNDARATK FDLNLEVTEL DHRLGCCLTY STDLFDEPRI AQMAEHWLNL LQALLADPQQ
RLSELPLLQE TERQHLLDSL GVEAGEQRLD QCIHSLFAEQ AHRRADAPAL TFAGQTLSYA
ELDAKANQLA WMLRERGVGP QIRVGLALPR SLDMVVGLLA ILKAGGAYVP LDPEYPLERL
HYMIEDSGVG LLLSDRALFA ALGELPAGVA RWCLEDDQPS LASFSSDELP FISLPQHQAY
LIYTSGSTGK PKGVVVSHGE IAMHCQAVIR RFDMRPDDCE LHFYSINFDA ATERLLVPLL
SGARVVLRAQ GQWDAEEICT LIRQQQVNIL GFTPSYGSQL AQWLATQGQT LPVRMCITGG
EALTGEHLQR IRAVFQPELL FNAYGPTETV VMPLASLAPQ QLEEGEASVP IGRVVGARVA
YILDADLALV PQGASGELYI GGAGLAQGYH QRPGMTAERF VADPFASNGG RLYRTGDLVR
QRADGLVEYL GRIDHQVKIR GFRIELGEIE TRLLEHAAVR EAIVLALDTP SGKQLAGYLV
SDVAGQGDEQ QAQWRESLKS HLKAQLPDYM VPTHLILLDS MPLTANGKLD RRALPAPDPG
LNRQHYVAPA SELEQQLAAI WCAVLNVEKV GLNDNFFELG GDSILSIQVV SRARQLGIHF
SPRDLFQHQT VQTLAAVATT RELIQAEQGL LDGNSGLTPI QHWFFDTPIP ERQHWNQSLL
LEPLSALHPN LLAQALRALL EQHDALRLSF TEHEGTWQAE HRAVTADTLL IQAQVSDMAE
CAALYADTQR SLDLHNGPLL RALLVDGPQG QQRLLMVIHH LVVDGVSWRV LLDDLQNAYR
QLRDATPVRF AAKTSAFRDW AARLQAYAGN ESLREELHVW QRQLGGSATS LPCHNPQGGR
QNRHAQTVSV RLDAERTRQL LQQAPSAYRT QVNDLLLTAL AQVVCRWSGQ PSTLIQLEGH
GRENLFDDID LTRTVGWFTS AYPLRLTPAP AADSAPGESI KAIKEQLRQV PHKGLGYGVL
RYLADSASQA AMQALPVAPI TFNYLGQFDQ SFADDALFRP LQESPGAAHD PQAPLPNELS
IDSQVYGGEL LLRWTFSAER YEPAAIEALA QDYLRQLQTL IAHCLADGSG GLTPSDFPLA
ALDQAQLDAL PVPPSQIEDV YPLTPMQEGM LLHTLLEPGT GLYYMQDRYR IDSALDPQRF
AQAWQAVIAR HEALRASFCW NIGETMLQVI HKPGSTPIDY LDWRDVPAEK QEPHLQALLK
SEREAGFALL DQPPFHLRLI RVDEARYWFM MSNHHILIDA WCRSLLMNDF FDIYTALGEG
RDAQLAPAPR YRDYIGWLQR RGLTQARDWW RDNLRGFERP TPIPSDRPFL REHAGDSGGM
VVGDCYTRLD ERDGAQLREL AQQHQLTVNT FAQAAWALTL RRMSGDRDVV FGVTVAGRPV
ELPQMQRTVG LFINTIALRV GMPADDQRCS VRQWLGQLLD SNMQLREYEY LPLVTIQENS
ELPKGQPLFD SLFVFENAPV EVSVLDRAQS LNATSDSGRT HTNYPLTAVC YPGDDLGLHL
SYDQRYFDES TVQGMLGEFK RLLLALVEGF HGDMAELALV SEQERAFLID GCNQSDHAYP
LDKSYVELFE AQVAAHPERI AVSCLDRQLS YAALNIASNR LGHALIEAGV GFDQPVAVLA
ERGVELPGMI IGSFKAGAGY LPLDPALPNS RLSDIIGQSA TPLLVCSAEC LEQGRALLDA
LPEASRPQLR VWEDLQQSDS AQHNPGRYSA PDNLAYVIFT SGSTGLPKGV MVEQHGMLNN
QLSKLPYLSL SDRDVIAQTA SQSFDISVWQ FLAAPLFGAR VDIVPNDIAR DPQALLAHVQ
AQRISVLESV PSLITRLLAE PHAALDSLRW MLPTGEAMPP ELASQWLQRY PQIGLVNAYG
PAECSDDVAF FRVDAQSTRS AYLPIGSPTD NNRLYLLDDA LDLVPLGAVG ELCVAGAGVG
RGYVADPQRT VPVFVPHPFG APGERLYRTG DLARRRKDGV LEYVGRVDHQ VKIRGYRIEL
GEIETRLLEL PAIRESVVLD VAGPLGKVLA AYLVPRSTAQ DHEALRDEVR NHLKASLPDY
MVPTHLVLLE AMPLTPNGKL HRKALPAPDV SLVQQDYQAP QTEMEQQLAT IWADVLKVER
VGITDNFFEL GGHSLLATQV VTRAQKRLQR NVPLRAMFEF NTVQALAQHL ESLGGAQVDE
QKFDRLADLM AELEGL
//
