ID Q5RAP7_PONAB Unreviewed; 506 AA.
AC Q5RAP7;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306};
DE EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306};
GN Name=DKFZp469I1833 {ECO:0000313|EMBL:CAH91163.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|EMBL:CAH91163.1};
RN [1] {ECO:0000313|EMBL:CAH91163.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:CAH91163.1};
RG The German cDNA Consortium;
RA Ansorge W., Krieger S., Regiert T., Rittmueller C., Schwager B.,
RA Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000256|ARBA:ARBA00004742}.
CC -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC family. {ECO:0000256|ARBA:ARBA00005796}.
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DR EMBL; CR858967; CAH91163.1; -; mRNA.
DR RefSeq; NP_001125680.1; NM_001132208.1.
DR AlphaFoldDB; Q5RAP7; -.
DR GeneID; 100172601; -.
DR KEGG; pon:100172601; -.
DR CTD; 5106; -.
DR OrthoDB; 5471652at2759; -.
DR UniPathway; UPA00138; -.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR CDD; cd00819; PEPCK_GTP; 1.
DR Gene3D; 3.90.228.20; -; 1.
DR Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1.
DR Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1.
DR HAMAP; MF_00452; PEPCK_GTP; 1.
DR InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR InterPro; IPR013035; PEP_carboxykinase_C.
DR InterPro; IPR008209; PEP_carboxykinase_GTP.
DR InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR InterPro; IPR035078; PEP_carboxykinase_GTP_N.
DR InterPro; IPR008210; PEP_carboxykinase_N.
DR PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1.
DR PANTHER; PTHR11561:SF11; PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL; 1.
DR Pfam; PF00821; PEPCK_GTP; 1.
DR Pfam; PF17297; PEPCK_N; 1.
DR SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1.
DR SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR PROSITE; PS00505; PEPCK_GTP; 1.
PE 2: Evidence at transcript level;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1..140
FT /note="Phosphoenolpyruvate carboxykinase GTP-utilising N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17297"
FT DOMAIN 144..502
FT /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT /evidence="ECO:0000259|Pfam:PF00821"
SQ SEQUENCE 506 AA; 55832 MW; 3F7281BDCEB88B5F CRC64;
MSPADFQRAV DERFPGCMQG RTMYVLPFSM GPVGSPLSRI GVQLTDSAYV VASMRIMTRL
GTPVLQALGD GDFVKCLHSV GQPLTGQGEP VSKWPCNPEK TLIGHVPDQR EIVSFGSGYG
GNSLLGKKCF ALRIASRLAR DEGWLAEHML ILGITSPAGK KRYVAAAFPS ACGKTNLAMM
RPALPGWKVE CVGDDIAWMR FDSEGRLRAI NPENGFFGVA PGTSATTNPN AMATIQSNTI
FTNVAETSDG GVYWEGIDQP LPPGVTVTSW LGKHWKPGDK EPCAHPNSRF CAPARQCPIM
DPAWEAPEGV PIDAIIFGGR RPKGVPLVYE AFNWRHGVFV GSAMRSESTA AAEHKGKIIM
HDPFAMRPFF GYNFGHYLEH WLSMEGRKGA QLPRIFHVNW FRRDEAGHFL WPGFGENARV
LDWICRRLEG EDSARETPIG LVPKEGALDL SGLGAIDTTQ LFSLPKDFWE QEVRDIRSCL
IEQVNQDLPK EVLAELEALE RRVHKM
//
