ID   Q6NVP3_XENTR            Unreviewed;       883 AA.
AC   Q6NVP3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Exosome component 10 {ECO:0000313|EMBL:AAH67962.1};
GN   Name=exosc10 {ECO:0000313|EMBL:AAH67962.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH67962.1};
RN   [1] {ECO:0000313|EMBL:AAH67962.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH67962.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC       {ECO:0000256|ARBA:ARBA00043957}.
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DR   EMBL; BC067962; AAH67962.1; -; mRNA.
DR   RefSeq; NP_998833.2; NM_213668.3.
DR   AlphaFoldDB; Q6NVP3; -.
DR   SMR; Q6NVP3; -.
DR   DNASU; 407941; -.
DR   GeneID; 407941; -.
DR   KEGG; xtr:407941; -.
DR   AGR; Xenbase:XB-GENE-946594; -.
DR   CTD; 5394; -.
DR   OrthoDB; 2880475at2759; -.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   CDD; cd06147; Rrp6p_like_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   InterPro; IPR049559; Rrp6p-like_exo.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF08066; PMC2NT; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   2: Evidence at transcript level;
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT   DOMAIN          499..579
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          731..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          830..883
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        731..803
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        855..873
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   883 AA;  101656 MW;  5B6B6664BCC311BB CRC64;
     MQKMENSVDI REDQDLSRDN SEPIPGFSDT DAFVKFALGT VVSATKASTG LPQGGDEYDF
     YRSFPGFRDS CESQGEHLLH CMSQVMQYHG LRSHIRDRSR VTLLEDKFDL LVDANDVILE
     KVGILLDEAS GLNRNQQPIL PAGLQPPKTI VSSWNRKTSD LSKKGKSETF RLLHAKNILR
     PQLKFKEKID NSNTPFVSKL FVKPNAQKPL PEVLRNRLER QQRQEDLDVP PALADFIHQQ
     RMKISEEDMF CHPYQYELDH FVPLESSMEK PDIQPVLSLQ DVPCKFVMKL EDLVALNEKL
     LQCAEFAVDL EHHSYRSFLG LTCLMQISTR TEDYIIDVLE LRSNMYILNE SFTNPSIIKV
     LHGADSDIEW LQKDFGLYIV NMFDTHQAAR ILNLGRHSLD HLLRLYCNVE SDKRYQLADW
     RIRPLPEEMI EYARADTHYL LFIYDKMRTA LLGAANEQQN LLQLVWQKSR DICLKKFTKS
     IFTEDSYLEL YQKQKKHLNT QQLTAFRLLF AWRDKIARQE DESTGYVLPN HMLLKITEEL
     PKEPQGIIAC CSPVPPLVRQ QINELSLLIH QARETPLLKS EISSAKKKGP MANPERMENL
     LFGPHDTSLQ LADNNHLYSG TGLQNSEGSL FTDEEPVVPV PMNPAFILSR ASITIFNGFE
     DEEVVPSKNW PVSQQKARNI LESFENPFKM FLPPEDRRAH VSQAAKLDPN TKMFEISKQW
     KLVSLAQQEK EAKAKEDARR QKREEKAARE QAKRDFKSSV ENQKSVREQA KDEESSKKRE
     RVSSEPGSET MKSDKKRIKN SEETQEPVSQ APFTPFDYSK SDFKMFAGSS NVKSQSEFDP
     NKQTHKGKKN ISTRKGHQLM GNKSMSFVAT KSDRGFQHSW PKR
//