ID Q7PRL0_ANOGA Unreviewed; 1226 AA.
AC Q7PRL0;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 24-JAN-2024, entry version 121.
DE SubName: Full=AGAP010735-PA {ECO:0000313|EMBL:EAA07043.5};
DE Flags: Fragment;
GN ORFNames=AgaP_AGAP010735 {ECO:0000313|EMBL:EAA07043.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA07043.5};
RN [1] {ECO:0000313|EMBL:EAA07043.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA07043.5};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA07043.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA07043.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA07043.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA07043.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA07043.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA07043.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA07043.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA07043.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA07043.5}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAAB01008848; EAA07043.5; -; Genomic_DNA.
DR RefSeq; XP_311449.4; XM_311449.5.
DR AlphaFoldDB; Q7PRL0; -.
DR PeroxiBase; 4151; AgaPxt01.
DR PaxDb; 7165-AGAP010735-PA; -.
DR GeneID; 1272536; -.
DR KEGG; aga:AgaP_AGAP010735; -.
DR VEuPathDB; VectorBase:AGAP029194; -.
DR VEuPathDB; VectorBase:AGAP029195; -.
DR eggNOG; KOG2408; Eukaryota.
DR HOGENOM; CLU_006087_5_2_1; -.
DR PhylomeDB; Q7PRL0; -.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09823; peroxinectin_like; 2.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 2.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF86; PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 3.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 2.
DR PROSITE; PS50292; PEROXIDASE_3; 2.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2}.
FT BINDING 989
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAA07043.5"
SQ SEQUENCE 1226 AA; 139280 MW; D2AF6809F6E8261C CRC64;
SPYRTFDGTC NNLQNPSWGS ANTPYGRLLP AEYGDGVYVP RRSITGAELP SARLLSMTMF
NEQNILDSQT TLVNMQFGQL VAHDMGLRAS SSDQVACCQN GRVVANPGRR CFPIPVRPDD
PVLSAGGIQC LDLVRTLNTC DVNPSSCANR QQAQQLNAAT SFLDLSVVYG NSGQQNAQLR
AFVGGRMKVD NRNDERSNIT PELTILHVAF LREHNRLAQQ LSIVHPLWND EKVFQEARRI
NIAQYQRIVY YEWLPYFLGI DQMTQRGLLV RTRDYVNDYT PAININDHMF NPTVLERNDG
YRMLTRGMTT QPMGRNDWSI DPEIKHFLFQ MRGRFGTDLK ALDIQRSRDH GIAGYNAFRQ
YCGLGRATRW EDFVELRLPR VTSMHHDIQL LSSLYSTVDD VDLTVAEFFE RHIPGTQAGP
TYHCILMEQF LRTRKGDRFF FENGNMPSSF TLLQLTEIRK ASMSRILCDN TPGVAQMQQR
AFQQISDANP LVPCTMMPAL DALNYSLLKN FLNVLFCPIL DHNLYAYYKS LRSKRYQNSA
GIQLRTKVRL KAQHHRIKNQ IQPSSLCGMA GGSYLKDQYS ALYYPGKIVT VQYRLSYVCY
LRMFTDYDKG EMIPDRIDIK ATLLRSCRAN ADRYKMWLVT RLFLMLSAIV VPHVLAQCDS
SSPYRTFDGT CNNLQNPSWG SANTPYGRLL PAEYGDGVYV PRRSKTGAQL PSARLLSMTM
FNDQNILDPR TTLVNMQFGQ LVAHDMGLRA GSSDQVACCQ NGRVVANPGR RCFAIPVRPD
DPVLSAGGIQ CLDLVRTLNT CDVNPSSCAN RQQAQQFNAA TSFLDLSVVY GNSGQQNAQL
RAFVGGRMKV DNRNGTDWPP RHPQATSACT LNAATDTCYL TGDERSNITP ELTILHVAFL
REHNRLAQQL CKARPLWNDE KVFQEARRIN IAQYQHIVYY EWLPYFLGID PMTQRGLLVR
TRDYVNDYTP SINPASLNSH ANGAFRYFHS SILGSLRYTE TESRAFAGAI NINDHMFNPT
VLERNDGYRM LTRGMTTQPM GRNDLSFDPE IKHFLFRMRG RFGTDLKALD IQRSRDHGIA
GYNAFRQYCG LGRATRWEDF VELRGPRDIQ LLSSLYSTVD DVDLTVAEFF ERHIPGTQAG
PTYHCILMEQ FLRTRKGDRF FFENGNRPSS FTPPQLNDIR KASMSRILCD NTPGVAQMQQ
RAFQQISDAN PLVPCTMMPS LDARLW
//
