ID Q8UV76_DANRE Unreviewed; 230 AA.
AC Q8UV76; A0A0N4SU08; A0A8N7XJE8; Q1MTL6;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE SubName: Full=Novel immune-type receptor 3b {ECO:0000313|Ensembl:ENSDARP00000135116, ECO:0000313|RefSeq:NP_001007212.1};
DE SubName: Full=Novel immune-type receptor 3d, allele 4 {ECO:0000313|EMBL:CAK03666.1};
GN Name=nitr3b {ECO:0000313|Ensembl:ENSDARP00000135116,
GN ECO:0000313|RefSeq:NP_001007212.1,
GN ECO:0000313|ZFIN:ZDB-GENE-001106-16};
GN Synonyms=nitr {ECO:0000313|RefSeq:NP_001007212.1}, nitr3
GN {ECO:0000313|RefSeq:NP_001007212.1}, nitr3b_2
GN {ECO:0000313|RefSeq:NP_001007212.1}, nitr3d_4
GN {ECO:0000313|EMBL:CAK03666.1}, nitr3d_7
GN {ECO:0000313|RefSeq:NP_001007212.1}, nitr3r.1
GN {ECO:0000313|RefSeq:NP_001007212.1}, nitr3r.3
GN {ECO:0000313|RefSeq:NP_001007212.1}, nitr3r.9
GN {ECO:0000313|RefSeq:NP_001007212.1}, si:dz221h6.1
GN {ECO:0000313|RefSeq:NP_001007212.1};
GN ORFNames=nitr3d_4-001 {ECO:0000313|EMBL:CAK03666.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAK03666.1};
RN [1] {ECO:0000313|RefSeq:NP_001007212.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18248169;
RA Phelps H.A., Neely M.N.;
RT "Evolution of the zebrafish model: from development to immunity and
RT infectious disease.";
RL Zebrafish 2:87-103(2005).
RN [2] {ECO:0000313|RefSeq:NP_001007212.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18565225; DOI=10.1186/1471-2148-8-177;
RA Desai S., Heffelfinger A.K., Orcutt T.M., Litman G.W., Yoder J.A.;
RT "The medaka novel immune-type receptor (NITR) gene clusters reveal an
RT extraordinary degree of divergence in variable domains.";
RL BMC Evol. Biol. 8:177-177(2008).
RN [3] {ECO:0000313|EMBL:CAK03666.1}
RP NUCLEOTIDE SEQUENCE.
RA Hammond S.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001007212.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20012603; DOI=10.1007/s00251-009-0416-5;
RA Yoder J.A., Turner P.M., Wright P.D., Wittamer V., Bertrand J.Y.,
RA Traver D., Litman G.W.;
RT "Developmental and tissue-specific expression of NITRs.";
RL Immunogenetics 62:117-122(2010).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000135116, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135116};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000135116}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135116};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_001007212.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR931785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL591420; CAD21620.1; -; Genomic_DNA.
DR EMBL; AL591482; CAD21620.1; JOINED; Genomic_DNA.
DR EMBL; AL591482; CAK03666.1; -; Genomic_DNA.
DR EMBL; AL591420; CAK03666.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001007212.1; NM_001007211.1.
DR PaxDb; 7955-ENSDARP00000053336; -.
DR Ensembl; ENSDART00000166546; ENSDARP00000135116; ENSDARG00000110886.
DR Ensembl; ENSDART00000166546.2; ENSDARP00000135116.2; ENSDARG00000110886.1.
DR GeneID; 60659; -.
DR KEGG; dre:60659; -.
DR AGR; ZFIN:ZDB-GENE-001106-16; -.
DR CTD; 60659; -.
DR ZFIN; ZDB-GENE-001106-16; nitr3b.
DR OMA; FANYYCA; -.
DR OrthoDB; 4047140at2759; -.
DR Proteomes; UP000000437; Alternate scaffold 7.
DR Proteomes; UP000000437; Chromosome 7.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00099; IgV; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR19433:SF127; LOC795524 PROTEIN-RELATED; 1.
DR PANTHER; PTHR19433; T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:CAK03666.1, ECO:0000313|RefSeq:NP_001007212.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..230
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005885431"
FT TRANSMEM 148..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 230 AA; 26085 MW; 9BF152D10599510B CRC64;
MSLQDCFTFF LLTFAYGTCE EDFIHQQPLV VAELGSSVTL PCFHSDDFIT TISWYKHSAG
KKPLLIAHSA PNSGSVTYQY AFNNTNRFFI TIASGSYNLS ILHLEKEDFA NYYCAKFFLN
IMMFGEGTIL LHNETDRNIS TSVSAPSFWT PVVCILLIIS VISIVMNIVL VIQKSRKKET
TEQLRSQINQ IKTDDLNYAA LHFSKTKPTT SRRSSMKTIQ ETIYSETTVH
//
