ID Q9FQE6_SOYBN Unreviewed; 235 AA.
AC Q9FQE6;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=Glutathione S-transferase {ECO:0000256|RuleBase:RU369102};
DE EC=2.5.1.18 {ECO:0000256|RuleBase:RU369102};
GN Name=GSTU21 {ECO:0000313|EMBL:AJE59658.1};
GN Synonyms=547581 {ECO:0000313|EnsemblPlants:KRH54548};
GN ORFNames=GLYMA_06G193500 {ECO:0000313|EMBL:KRH54548.1};
OS Glycine max (Soybean) (Glycine hispida).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847 {ECO:0000313|EMBL:AAG34802.1};
RN [1] {ECO:0000313|EMBL:AAG34802.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11080288; DOI=10.1104/pp.124.3.1105;
RA McGonigle B., Keeler S.J., Lau S.M., Koeppe M.K., O'Keefe D.P.;
RT "A genomics approach to the comprehensive analysis of the glutathione S-
RT transferase gene family in soybean and maize.";
RL Plant Physiol. 124:1105-1120(2000).
RN [2] {ECO:0000313|EMBL:KRH54548.1, ECO:0000313|EnsemblPlants:KRH54548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Williams 82 {ECO:0000313|EnsemblPlants:KRH54548};
RC TISSUE=Callus {ECO:0000313|EMBL:KRH54548.1};
RX PubMed=20075913; DOI=10.1038/nature08670;
RA Schmutz J., Cannon S.B., Schlueter J., Ma J., Mitros T., Nelson W.,
RA Hyten D.L., Song Q., Thelen J.J., Cheng J., Xu D., Hellsten U., May G.D.,
RA Yu Y., Sakurai T., Umezawa T., Bhattacharyya M.K., Sandhu D.,
RA Valliyodan B., Lindquist E., Peto M., Grant D., Shu S., Goodstein D.,
RA Barry K., Futrell-Griggs M., Abernathy B., Du J., Tian Z., Zhu L., Gill N.,
RA Joshi T., Libault M., Sethuraman A., Zhang X.-C., Shinozaki K.,
RA Nguyen H.T., Wing R.A., Cregan P., Specht J., Grimwood J., Rokhsar D.,
RA Stacey G., Shoemaker R.C., Jackson S.A.;
RT "Genome sequence of the palaeopolyploid soybean.";
RL Nature 463:178-183(2010).
RN [3] {ECO:0000313|EMBL:AJE59658.1}
RP NUCLEOTIDE SEQUENCE.
RA Liu H.-J.;
RT "Evolutionary and functional dynamics of recent duplicate genes created by
RT whole genome duplication.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblPlants:KRH54548}
RP IDENTIFICATION.
RC STRAIN=Williams 82 {ECO:0000313|EnsemblPlants:KRH54548};
RG EnsemblPlants;
RL Submitted (FEB-2018) to UniProtKB.
RN [5] {ECO:0000313|EMBL:KRH54548.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Callus {ECO:0000313|EMBL:KRH54548.1};
RA Schmutz J., Cannon S., Schlueter J., Ma J., Mitros T., Nelson W., Hyten D.,
RA Song Q., Thelen J., Cheng J., Xu D., Hellsten U., May G., Yu Y.,
RA Sakurai T., Umezawa T., Bhattacharyya M., Sandhu D., Valliyodan B.,
RA Lindquist E., Peto M., Grant D., Shu S., Goodstein D., Barry K.,
RA Futrell-Griggs M., Abernathy B., Du J., Tian Z., Zhu L., Gill N., Joshi T.,
RA Libault M., Sethuraman A., Zhang X., Shinozaki K., Nguyen H., Wing R.,
RA Cregan P., Specht J., Grimwood J., Rokhsar D., Stacey G., Shoemaker R.,
RA Jackson S.;
RT "WGS assembly of Glycine max.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Is involved in the conjugation of reduced glutathione to a
CC wide number of exogenous and endogenous hydrophobic electrophiles.
CC {ECO:0000256|RuleBase:RU369102}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000710,
CC ECO:0000256|RuleBase:RU369102};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|RuleBase:RU369102}.
CC -!- SIMILARITY: Belongs to the GST superfamily.
CC {ECO:0000256|RuleBase:RU369102}.
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DR EMBL; AF243367; AAG34802.1; -; mRNA.
DR EMBL; KM818439; AJE59658.1; -; mRNA.
DR EMBL; CM000839; KRH54548.1; -; Genomic_DNA.
DR RefSeq; NP_001238708.1; NM_001251779.1.
DR AlphaFoldDB; Q9FQE6; -.
DR SMR; Q9FQE6; -.
DR STRING; 3847.Q9FQE6; -.
DR PaxDb; 3847-GLYMA06G20730-1; -.
DR EnsemblPlants; KRH54548; KRH54548; GLYMA_06G193500.
DR GeneID; 547581; -.
DR Gramene; KRH54548; KRH54548; GLYMA_06G193500.
DR KEGG; gmx:547581; -.
DR eggNOG; KOG0406; Eukaryota.
DR HOGENOM; CLU_011226_18_0_1; -.
DR InParanoid; Q9FQE6; -.
DR OMA; CKAQEEV; -.
DR OrthoDB; 767442at2759; -.
DR Proteomes; UP000008827; Chromosome 6.
DR ExpressionAtlas; Q9FQE6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd03185; GST_C_Tau; 1.
DR CDD; cd03058; GST_N_Tau; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR045074; GST_C_Tau.
DR InterPro; IPR045073; Omega/Tau-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11260:SF791; GLUTATHIONE S-TRANSFERASE U10; 1.
DR PANTHER; PTHR11260; GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING; 1.
DR Pfam; PF02798; GST_N; 1.
DR SFLD; SFLDG01152; Main.3:_Omega-_and_Tau-like; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|RuleBase:RU369102};
KW Reference proteome {ECO:0000313|Proteomes:UP000008827};
KW Transferase {ECO:0000256|RuleBase:RU369102, ECO:0000313|EMBL:AAG34802.1}.
FT DOMAIN 5..84
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 90..228
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 235 AA; 26603 MW; 44D811401A975A0B CRC64;
MAEQDKVILH GMWASPYAKR VELALNFKGI PYEYVEEDLR NKSDLLLKYN PVHKKVPVLV
HNGKAIAESM VILEYIDETW KDGPKLLPSD SYKRAQARFW CHFIQDQLME STFLVVKTDG
EAQQKAIDHV YEKLKVLEDG MKTYLGEGNA IISGVENNFG ILDIVFCALY GAYKAHEEVI
GLKFIVPEKF PVLFSWLMAI AEVEAVKIAT PPHEKTVGIL QLFRLSALKS SSATE
//
