ID   Q9I157_PSEAE            Unreviewed;      4342 AA.
AC   Q9I157;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 135.
DE   SubName: Full=PvdL {ECO:0000313|EMBL:AAG05812.1};
GN   Name=pvdL {ECO:0000313|EMBL:AAG05812.1};
GN   OrderedLocusNames=PA2424 {ECO:0000313|EMBL:AAG05812.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG05812.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG05812.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA   Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA   Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; AE004091; AAG05812.1; -; Genomic_DNA.
DR   PIR; H83343; H83343.
DR   RefSeq; NP_251114.1; NC_002516.2.
DR   RefSeq; WP_003115540.1; NZ_QZGE01000027.1.
DR   SMR; Q9I157; -.
DR   IntAct; Q9I157; 1.
DR   MINT; Q9I157; -.
DR   STRING; 208964.PA2424; -.
DR   PaxDb; 208964-PA2424; -.
DR   GeneID; 882838; -.
DR   KEGG; pae:PA2424; -.
DR   PATRIC; fig|208964.12.peg.2534; -.
DR   PseudoCAP; PA2424; -.
DR   HOGENOM; CLU_000022_11_0_6; -.
DR   InParanoid; Q9I157; -.
DR   OrthoDB; 9757559at2; -.
DR   PhylomeDB; Q9I157; -.
DR   BioCyc; MetaCyc:MONOMER-15310; -.
DR   BioCyc; PAER208964:G1FZ6-2461-MONOMER; -.
DR   PHI-base; PHI:123483; -.
DR   PHI-base; PHI:6991; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IDA:PseudoCAP.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   GO; GO:0002049; P:pyoverdine biosynthetic process; IDA:PseudoCAP.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd17646; A_NRPS_AB3403-like; 1.
DR   CDD; cd17649; A_NRPS_PvdJ-like; 1.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   CDD; cd19534; E_NRPS; 1.
DR   CDD; cd05931; FAAL; 1.
DR   CDD; cd19531; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 3.40.50.980; -; 6.
DR   Gene3D; 1.10.1200.10; ACP-like; 4.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR040097; FAAL/FAAC.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR   PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF00550; PP-binding; 4.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438}.
FT   DOMAIN          581..656
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1634..1709
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2703..2777
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4245..4320
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   4342 AA;  480297 MW;  6A559D342ECC1C9A CRC64;
     MMDAFELPTT LVQALRRRAV QEPERLALRF LAEDDGEGVV LSYRDLDLRA RSIAAALQAH
     AQLGDRAVLL FPSGPDYVAA FFGCLYAGVI AVPAYPPESA RRHHQERLLS IIADAEPRLV
     LTTADLREPL LQMNAQLSAA NAPQLLCVDQ LDPAVAEAWD EPQVRPEHIA FLQYTSGSTA
     LPKGVQVSHG NLVANEVLIR RGFGIGADDV IVSWLPLYHD MGLIGGLLQP IFSGVPCVLM
     SPRYFLERPV RWLEAISQYG GTVSGGPDFA YRLCSERVAE SALQRLDLSG WRVAFSGSEP
     IRQDSLERFA EKFAASRFDA SSFFACYGLA EATLFVTGGQ RGQGIPALAV DGEALARNRI
     AEGEGSVLMC CGRSQPEHAV LIVDAASGEV LGDDNVGEIW AAGPSIAHGY WRNPEASAKA
     FVERDGRTWL RTGDLGFLRD GELFVTGRLK DMLIVRGHNL YPQDIERTVE SEVPSARKGR
     VAAFAVTVDG EEGIGIAAEI GRGVQKSVPA QELIDSIRQA VAEAYQEAPK VVALLNPGAL
     PKTSSGKLQR SACRLRLEDG SLDSYALFPG LQAVQEAQPP AGDDELLARI GEIWKARLGV
     AQVAPRDHFF LLGGNSIGAA QVVAQVRDSL GVALDLRQLF EAPTLQAFSA TVARQLAAGL
     PAEAPMAHLP RGVDLPQSAA QQRLWLTWQI DPQSAAYNIP GGLRLRGELD EAALRASFQR
     LVERHEALRT RFLERDGAAL QRIDERGEFA WQFVDLAALA EHERAAAAAQ RREAEAQQPF
     DLEKGPLLRV SLVRLDEQEH QLWVTLHHIV ADGWSLNLLL DEFSRLYAEA CGGQPADLAP
     LELHYAEFAA WQRQWLDAGE GARQLAYWRE RLGDTAPVLE LATDHPRTAR QASPAARYSL
     RVDEALARAI REAALDHEAS VFMWLLAAFQ ALLHRHSGQG EIRIGVPSAN RQRLETQGLV
     GFFINTLVLR GTPRARQPFA ALLGEAREAT LGAQANQDLP FDQVLAACGQ GGQLFQVLFN
     HQQRDLSALR RLPGLLADEL PWHSREAKFD LQLQSEEDAR GRLTLNFDYA ADLFDEASIR
     RFAAQYLELL RQVAEDPQRC LGDIALVDAE QAAHLAEWGS APCEPARAWL PELLERQLAQ
     SAERVALEWD GGSLGYAELH ARANRLAHYL RDKGVGPDVR VAICAERSPQ LLVGLLAIVK
     AGGAYVPLDP DYPSERLAYM LADSGVELLL TQAHLFERLP GAEGVTPICL DSLKLDNWPS
     QAPGLHLHGD NLAYVIYTSG STGQPKGVGN THAALAERLQ WMQATYTLDG DDVLMQKAPV
     SFDVSVWECF WPLVTGCRLV LAAPGEHRDP ARLVELVRQF GVTTLHFVPP LLQLFIDEPG
     VAACGSLRRL FSGGEALPAE LRNRVLQRLP AVALHNRYGP TETAINVTHW QCRAEDGERS
     PIGRPLGNVV CRVLDAEFNL LPAGVAGELC IGGLGLARGY LGRPALSAER FVADPFSAAG
     ERLYRTGDRA RWNADGVLEY LGRLDQQVKL RGFRIEPEEI QARLLAQPGV AQAVVVIREG
     VAGSQLVGYY TGAVGAEAEA EQNQRLRAAL QAELPEYMVP TQLMRLAQMP LGPSGKLDTR
     ALPEPVWQQR EHVEPRTELQ RRIAAIWSEV LGLPRVGLRD DFFELGGHSL LATRIVSRTR
     QACDVELPLR ALFEASELEA FCEQVRAAQA AGRTDSHGAI RRIDREQPVP LSYSQQRMWF
     LWQLEPDSPA YNVGGLARLS GPLDVARFEA ALQALVQRHE TLRTTFPSVD GVPVQRVHGD
     GGLHMDWQDF SALDRDSRQQ HLQTLADSEA HRPFDLESGP LLRVCMVKMA EREHYLVVTL
     HHIVTEGWAM DIFARELGAL YEAFLDDRES PLEPLPVQYL DYSVWQREWL ESGERQRQLD
     YWKAQLGNEH PLLELPGDRP RPPVQSHQGD LYRFDLSPEL AERVRRFNAA RGLTMFMTMT
     ATLAALLYRY SGQQDLRIGA PVANRIRPES EGLIGAFLNT QVLRCRLDGQ MSVGELLEQV
     RQTVIDGQSH QDLPFDHLVE ALQPPRSAAY NPLFQVMCNV QRWEFQQTRQ LAGMTVEYIA
     NDARATKFDL NLEVTDLDQR LGCCLTYSRD LFDEPRIARM AGHWQNLLEA LLGDPQRRIA
     ELPLFAAEER KQLLLAGTAG EAGLQDTLHG LFAARVAASP QAPALTFAGQ TLSYAELDAR
     SNRLARVLRS HGVGPEVRVG LALERSLEMV VGLLAILKAG GAYVPLDPEY PLERLQYMIE
     DSGVRLLLSH AALFEALGEL PAGVARWCLE EDGPALDAED PAPLAALSGP QHQAYLIYTS
     GSTGKPKGVA VSHGEIAMHC AAVIECFGMR AEDCELHFYS INFDAASERL LAPLLCGARV
     VLRAQGQWGA EEICELIRAE GVSILGFTPS YGSQLAQWLE SQGRQLPVRM CITGGEALTG
     EHLQRIRQAF APASFFNAYG PTETVVMPLA CLAPERLEEG AASVPIGSVV GARVAYILDA
     DLALVPQGAT GELYVGGAGL ARGYHERPAL SAERFVPDPF AAEGGRLYRT GDLVRLCDNG
     QVEYVGRIDH QVKIRGFRIE LGEIEARLLE HPQVREALVL ALDSPSGKQL AGYVASAVAE
     QDEDAQAALR EALKTHLKQQ LPDYMVPAHL LLLASLPLTA NGKLDRRALP APDPALNRQA
     YEAPRSVLEQ QLAGVWREVL NVERVGLGDN FFELGGDSIL SIQVVSRARQ LGIHFSPRDL
     FQHQTVQSLA AVARHSQASQ AEQGPVQGDS ALTPIQHWFF DLPLARREHW NQALLLQPRQ
     AIDLGLLRKS LQRLVEQHDA LRLAFRQVDG EWLAQHRPLR EQELLWHVPV QSFDECAELF
     AKAQRSLDLE QGPLLRAVLV DGPAGEQRLL LAIHHLVVDG VSWRVLLEDL QQVYRQFAEG
     AEPALPAKTS AFRDWAGRLQ AYAGSESLRE ELGWWQARLG GQPVEWPCDR PQGDNREALA
     ESVSLRLDPQ RTRQLLQQAP AAYRTQVNDL LLTALARVLC RWSGQPSTLV QLEGHGREAL
     FDDIDLTRSV GWFTSAYPLR LTPAQSPGES IKAIKEQLRA VPHKGLGYGV LRYLADPAVR
     QAMAALPTAP ITFNYLGQFD QSFADALFQP LDQPTGPIHD EQAPLPNELS VDGQVYGGEL
     VLRWTYSRER YDARTVNELA QAYLAELQAL IEHCLEDGAG GLTPSDFPLA QLSQAQLDAL
     AVPAGEIEDV YPLTPMQEGL LLHTLLEPGT GIYYMQDRYR IDSPLDPERF AAAWQAVVAR
     HEALRASFVW NAGETMLQVI HKPGRTRIEF LDWSELPEDG HEERLQALHK REREAGFDLL
     EQPPFHLRLI RLGEARYWFM MSNHHILIDA WCRGLLMNDF FEIYSALGES RPANLPTPPR
     YRDYIAWLQR QDLEQSRRWW SESLRGFERP TLVPSDRPFL REHAGESGGM IVGDRYTRLD
     AADGARLREL AQRYQLTVNT FAQAAWALTL RRFSGERDVL FGVTVAGRPV GMPEMQRTVG
     LFINSIPLRV QMPAAGQRCT VREWLNRLFE RNLELREHEH LPLVAIQESS ELPKGQPLFD
     SLFVFENAPV EVSVLDRAQS LNASSDSGRT HTNFPLTVVC YPGDDLGLHL SYDQRYFEAP
     TVERLLGEFK RLLLALADGF HGELEALPLL GEDERDFLLD GCNRSARDYP LEQGYVRLFE
     AQVAAHPQRI AASCLEQRWS YAELNRRANR LGHALRAAGV GIDQPVALLA ERGLDLLGMI
     VGSFKAGAGY LPLDPGHPTQ RLTRIVELSR TLVLVCTQAC REQALALFDE LGCVDRPRLL
     VWDEIQQGEG AEHDPQVYSG PQNLAYVIYT SGSTGLPKGV MVEQAGMLNN QLSKVPYLEL
     DENDVIAQTA SQSFDISVWQ FLAAPLFGAR VAIVPNAVAH DPQGLLAHVG EQGITVLESV
     PSLIQGMLAE ERQALDGLRW MLPTGEAMPP ELARQWLKRY PRIGLVNAYG PAECSDDVAF
     FRVDLASTES TYLPIGSPTD NNRLYLLGAG ADDAFELVPL GAVGELCVAG TGVGRGYVGD
     PLRTAQAFVP HPFGAPGERL YRTGDLARRR ADGVLEYVGR IDHQVKIRGF RIELGEIEAR
     LHERADVREA AVAVQEGANG KYLVGYLVPG ETPRSSADSP AGLMVEQGAW FERIKQQLRA
     DLPDYMVPLH WLVLDRMPLN ANGKLDRKAL PALDIGQMQN QAYQAPRNEL EETLARIWAE
     VLKVERVGVF DNFFELGGHS LLATQIASRV QKALQRNVPL RAMFECTTVE ELASYIESLA
     PSEISEQKAE RLNDLMSKLE ML
//