ID R9SNB3_9EURY Unreviewed; 498 AA.
AC R9SNB3;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Lactaldehyde dehydrogenase {ECO:0000256|ARBA:ARBA00019663};
DE EC=1.2.1.22 {ECO:0000256|ARBA:ARBA00013052};
GN ORFNames=Abm4_1628 {ECO:0000313|EMBL:AGN17491.1};
OS Methanobrevibacter sp. AbM4.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=224719 {ECO:0000313|EMBL:AGN17491.1, ECO:0000313|Proteomes:UP000014066};
RN [1] {ECO:0000313|EMBL:AGN17491.1, ECO:0000313|Proteomes:UP000014066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AbM4 {ECO:0000313|EMBL:AGN17491.1};
RA Leahy S.C., Kelly W.J., Li D., Lambie S.C., Altermann E., Li Y.,
RA Attwood G.T.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGN17491.1, ECO:0000313|Proteomes:UP000014066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abm4 {ECO:0000313|Proteomes:UP000014066};
RG Pastoral Greenhouse Gas Research Consortium;
RA Leahy S.C., Kelly W.J., Li D., Lambie S.C., Altermann E., Li Y.,
RA Attwood G.T.;
RT "The comlpete genome sequence of Methanobrevibacter sp. AbM4.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:14277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16651, ChEBI:CHEBI:18041, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001091};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005036}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CP004050; AGN17491.1; -; Genomic_DNA.
DR RefSeq; WP_016359188.1; NC_021355.1.
DR AlphaFoldDB; R9SNB3; -.
DR STRING; 224719.Abm4_1628; -.
DR GeneID; 15799118; -.
DR KEGG; meb:Abm4_1628; -.
DR eggNOG; arCOG01252; Archaea.
DR HOGENOM; CLU_005391_0_1_2; -.
DR OrthoDB; 6342at2157; -.
DR UniPathway; UPA00071; -.
DR Proteomes; UP000014066; Chromosome.
DR GO; GO:0008911; F:lactaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000014066}.
FT DOMAIN 21..483
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 498 AA; 54693 MW; F131D583EC8DED83 CRC64;
MEKIPNNPAQ EKYQLYINGQ WKDASDGSTF ETFCPANGEK LATCAEATNA DVDEAVDAAN
AAFPDWKDVE PIEREEILLK VADIIDDNAD KLAMIETLDN GKPIRENMAI DMPFSSDHFR
YFAGAVRAEE GSATMLDNNT LSLILREPIG VVGQIVPWNF PFLMAAWKLA PVLAAGCCTV
FHPSSSTPLS VLEFAKMTEK VIPKGVFNVI TGKGSKSGQY MLEHPGFRKL AFTGSTEIGC
NVANCAASRL IPSTLELGGK SANIYFDDCK WDMAMDGLQL GILFNQGQVC CAGSRVFVQE
DIYDKFVKEA VDQFGKINVN MPWLEDTQMG SQINERQVEK IEKCVQDGVK EGATIAVGGE
RFKEGPLSEG SFFKPTLLTN VTNDMKVAQE EIFGPVAVVI PFKDEEDVIE MANDSSYGLG
GAVWTRDINR AISVCNAIET GRMWVNTYNS IPAGAPFGGY KQSGIGRETH KVILEHYTQM
KNIMINLSEQ PSGFYPKK
//
